RESUMEN
Swedish massage technique includes mechanically activated muscular tissue and also skin, tendons, fascias, and connected tissue, which indirectly regulates the tonus of the autonomous nervous system. This study set out to examine the effects of Swedish massage on blood pressure. Healthy males were given massage treatment at the Karolinska Hospital, Stockholm, Sweden. Treatment was over a 12-week period divided into three parts, each consisting of 4 weeks. Two treatment periods contained massage treatment either on back, neck and chest (BNC), or leg, arm and face (LAF), with an in between washout period. The first treatment period with massage decreased systolic blood pressure directly after treatment (BNC: P<0.005, LAF: P<0.01), but no significant changes were seen in diastolic blood pressure. In the second period, BNC massage decreased systolic (P<0.005) and diastolic (P<0.005) blood pressure whereas LAF massage (P<0.05) increased systolic blood pressure. Swedish massage on the BNC resulted in a minor decrease in blood pressure possibly due to sympathetic inhibition. It may be suggested that massage may be tried as a complementary therapy in patients suffering from increased blood pressure due to stress.
Asunto(s)
Presión Sanguínea/fisiología , Masaje/métodos , Adulto , Brazo , Dorso , Estudios Cruzados , Cara , Humanos , Pierna , Masculino , Cuello , Tórax , Resultado del TratamientoRESUMEN
Temporomandibular joint (TMJ) arthritis was induced in female Lewis rats by unilateral injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the TMJ. Control rats received paraffin oil by the same route. Arthritic and control rats were pretreated either with capsaicin or denervation of the mandibular branch of the trigeminal nerve. Tissues were collected for neuropeptide extraction and analysed by radioimmunoassay and reverse-phase high-performance liquid chromatography. In all groups, the levels of substance P-(SP), calcitonin gene-related peptide- (CGRP) and neuropeptide Y- (NPY) like immunoreactivity (LI) were higher in the trigeminal ganglia than in the TMJs. In control rats, capsaicin significantly lowered the levels of SP-LI in the trigeminal ganglia and TMJ, but not CGRP-LI and NPY-LI. In the arthritic rats, capsaicin pretreatment significantly lowered the SP-LI and CGRP-LI in the trigeminal ganglia and TMJ, but not the NPY-LI. In the trigeminal ganglia the unilateral denervation significantly lowered SP-LI in control rats, and in arthritic rats SP-LI and CGRP-LI. On the denervated side of the arthritic TMJ, NPY-LI, SP-LI and CGRP- LI were significantly lowered as compared to the arthritic control rats and to the contralateral side. In this rat model, pretreatment with capsaicin and surgical denervation decreased the neuropeptide content in the trigeminal ganglia and the TMJ. The results clearly demonstrate a close interaction between increased neuropeptide release from sensory and sympathetic neurones after induction of arthritis in the rat.
Asunto(s)
Artritis/prevención & control , Capsaicina/uso terapéutico , Neurotoxinas/uso terapéutico , Trastornos de la Articulación Temporomandibular/prevención & control , Animales , Artritis/etiología , Artritis/metabolismo , Artritis/cirugía , Péptido Relacionado con Gen de Calcitonina/análisis , Cromatografía Líquida de Alta Presión/métodos , Desnervación , Modelos Animales de Enfermedad , Femenino , Nervio Mandibular/metabolismo , Nervio Mandibular/cirugía , Neuronas Aferentes/efectos de los fármacos , Neuronas Aferentes/metabolismo , Neuropéptido Y/análisis , Micobacterias no Tuberculosas , Radioinmunoensayo , Ratas , Ratas Endogámicas Lew , Sustancia P/análisis , Sistema Nervioso Simpático/efectos de los fármacos , Sistema Nervioso Simpático/metabolismo , Articulación Temporomandibular/efectos de los fármacos , Articulación Temporomandibular/inervación , Articulación Temporomandibular/metabolismo , Trastornos de la Articulación Temporomandibular/etiología , Trastornos de la Articulación Temporomandibular/metabolismo , Trastornos de la Articulación Temporomandibular/cirugía , Ganglio del Trigémino/efectos de los fármacos , Ganglio del Trigémino/metabolismoRESUMEN
To study the interaction between human recombinant interleukin-1 alpha and the nervous system, substance P-, neurokinin A-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the cerebrospinal fluid, plasma, and temporomandibular joint (TMJ) perfusates of rats during acute experimental monarthritis were examined. The right TMJs of the experimental rats were injected with 0.01 mL of human recombinant interleukin-1 alpha. The right TMJs of control rats were injected with 0.01 mL of saline. Cerebrospinal fluid, plasma, and perfusates from the right TMJs were obtained at 2, 6, and 24 hours following injection, and neuropeptide-like immunoreactivity was analyzed by specific radioimmunoassays. Values of neuropeptide-like immunoreactivity for the experimental rats were compared with those of the control rats. In the experimental group, substance P-, neurokinin A-, and calcitonin gene-related peptide-like immunoreactivities were increased in cerebrospinal fluid compared to those of the control group. In plasma, no changes in neuropeptide-like immunoreactivities rose significantly in the TMJ perfusates. Most pronounced changes in neuropeptide Y-like immunoreactivity occurred intra-articularly in the TMJ perfusates. The results indicate that the contribution of the nervous system to human recombinant interleukin-1 alpha-induced monarthritis is most pronounced in the affected joint.