Construction of Evaluating Method and Experimental Research for Targeting of Traditional Chinese Medicine Preparations Based on Supramolecular Qi Chromatography Theory / 中国实验方剂学杂志

Objective:To construct the targeting evaluation method of traditional Chinese medicine （TCM） preparations based on supramolecular Qi chromatography theory， and to study the liver targeting effect of Bupleuri Radix on Pien Tze Huang. Method:The molecular connectivity index （MCI） was used to analyze the characteristics of imprinted template and liver targeting tendency of TCM mainly attributed to liver meridian and components of Pien Tze Huang， and combined with target dynamics and total statistical moment principle， aimed at the independent action characteristics of multi-component imprinted template of TCM， a method for evaluating the targeting of TCM preparations was established. Hepatoma rats in Pien Tze Huang group， Bupleuri Radix<italic> </italic>group， Pien Tze Huang+Bupleuri Radix group and blank group were tested and verified. Result:After the average value of MCI of TCM mainly attributed to liver meridian was deducted， the MCI similarity between Pien Tze Huang group and Bupleuri Radix group was 0.376 8， Pien Tze Huang+Bupleuri Radix group and Bupleuri Radix group was 0.988 2， so it was predicted that Bupleuri Radix could enhance the liver targeting of Pien Tze Huang. A system for evaluating the targeting of TCM compounds was established， including relative total uptake efficiency （RUE_T）， relative total concentration （RC_T）， relative imprinted tendency （RIT_T） and relative imprinted variance （RIV_T）. The RUE_T and RC_T of liver were the highest in all tissues （RUE_T=1.88>1，RC_T<italic>=</italic>2.30>1）， and the corresponding values of other tissues were all <1， indicating that Pien Tze Huang combined with Bupleuri Radix could increase its distribution in liver and enhance liver targeting. Except for plasma， the RIT_T and RIV_T of other tissues fluctuated around 1.0， indicating that targeted modification did not change imprinted tendency of Pien Tze Huang and had no significant effect on the types of components. Conclusion:Under the guidance of supramolecular Qi chromatography theory， a targeting evaluation parameter system can be established to characterize the multi-component imprinted effect of TCM preparations by MCI and total statistical moment parameters， so as to realize the evaluation of targeting of TCM preparations. The addition of Bupleuri Radix can increase the liver targeting of Pien Tze Huang.

Treatment of Sepsis with Chinese Medicine： A Review Based on NF-κB Signaling Pathway / 中国实验方剂学杂志

Sepsis， a common critical disease in the intensive care unit（ICU）， features high morbidity and mortality. At present， it is mainly tackled with western medicine， which may trigger a series of problems like antibiotic resistance， adverse hormonal reactions， and high cost after a long-term use. Therefore， exploring new efficient， safe， and cheap drugs and treatment modes has become the focus of our research at this stage. By virtue of unique advantages including "the concept of holism and individualized treatment based on syndrome differentiation"， Chinese medicine has accumulated quite rich experience in the prevention and treatment of sepsis. In recent years， research on the regulation of Chinese medicine on nuclear transcription factor-κB（NF-κB） signaling pathway in sepsis has kept emerging. On this basis， this paper reviewed the etiology and pathogenesis of sepsis， syndrome differentiation and treatment， NF-κB signaling pathway， and its intervention with Chinese medicine. It has been found that some single Chinese herbs and their extracts， Chinese herbal compounds， and Chinese herbal injections effectively inhibit the expression of such inflammatory factors as NF-κB-mediated tumor necrosis factor-α（TNF-α）， interleukin-1（IL-1）， and IL-6 as well as the related proteins， reduce the systemic inflammatory response and organ injury， and improve the prognosis by regulating the activation of NF-κB signaling pathway and the immune function of macrophages. However， due to the limitations of objective conditions， some studies also have the problems of fuzzy pro-inflammatory anti-inflammatory balance mechanism， unclear pharmacokinetics and low drug safety evaluation， which need to be further studied and explored in order to provide a new theoretical basis and diagnosis and treatment thinking for the treatment of sepsis with traditional Chinese medicine.

Characteristics of supramolecular imprinting template on liver meridian tropism of traditional Chinese medicine based on molecular connectivity index / 中国中药杂志

The molecular connectivity index was adopted to explore the characteristics of supramolecular imprinting template of herbs distributed to liver meridian, in order to provide scientific basis for traditional Chinese medicines(TCMs) distributed to liver meridian. In this paper, with "12th five-year plan" national planning textbooks Science of Traditional Chinese Medicine and Chemistry of Traditional Chinese Medicine as the blueprint, literatures and TCMSP sub-databases in TCM pharmacology of northwest science and technology university of agriculture and forestry were retrieved to collect and summarize active constituents of TCM distributed to liver meridian, and calculate the molecular connectivity index. The average molecular connectivity index of ingredients distributed to liver meridian was 9.47, which was close to flavonoid glycosides' (9.17±2.11) and terpenes (9.30±3.62). Therefore, it is inferred that template molecule of liver meridian is similar to physicochemical property of flavonoid glycosides and terpenes, which could be best matched with imprinting template of liver meridian.

Evaluation of inverse gas chromatography (IGC) methods to measure astragaloside solubility parameter from Buyang Huanwu decoction / 中国中药杂志

The solubility parameter determination of astrageloside from Buyang Huanwu decoction with inverse gas chromatography (IGC) method evaluation was investigated in this paper. Di-n-octyl phthalate Kwai alternative sample was used to carry out methodological study. The accuracy of the measured correlation coefficient was 0.992 1. Experimental precision measured by IGC experiments showed that the results were accurate and reliable. The sample was uniformly coated on the surface of an inert carrier and N2 gas was carrier gas, a variety of polar solvents such as isopropanol, toluene, acetone, chloroform, cyclohexane as probes. TCD detector temperature was 150 degrees C, gas room temperature was 120 degrees C. Similar headspace method was used whichever over 1 μL gas into the GC measurement, Retention time t(R), t(0) and all the parameters of air and probes molecules within the column were tested. Astragaloside solubility parameter was (21.02 ± 2.4) [J x cm(-3)] ½, literature value was 19.24 [J x cm(-3)] ½, and relevant coefficient was 0.984 5. IGC method is effective and accurate to measure ingredients solubility parameter.

Clinical observation on acupuncture for treatment of chronic atrophic gastritis / 中国针灸

<p><b>OBJECTIVE</b>To compare the therapeutic effects of acupuncture and western medicine for treatment of chronic atrophic gastritis.</p><p><b>METHODS</b>Eighty cases of chronic atrophic gastritis were randomly divided into an observation group and a control group, 40 cases in each group. The observation group was treated with acupuncture and moxibustion on Guanyuan (CV 4), Qihai (CV 6), Zusanli (ST 36), Xuehai (SP 10), Geshu (BL 17); and the control group with oral administration of western medicine, Omeprazole and Amoxicillin, etc. Evaluation of the scores of clinical symptoms, gastroscopic inspection and histopathologic examination of the gastric mucosa were carried out before treatment and after treatment of 4 and 8 weeks in each group to compare the therapeutic effects between the two groups.</p><p><b>RESULTS</b>The total effective rate of 92.5% in the acupuncture group was better than 75.0% in the con trol group (P < 0.05). For the pathologic changes of gastric mucosa by the gastroscopic inspection, the total effec tive rate of 85.0% in the acupuncture group was superior to 65.0% in the control group (P < 0.05), and for the improvement of histopathologic aspect, the total effective rate of 87.5% in the acupuncture group was better than 65.0% in the control group (P < 0.05).</p><p><b>CONCLUSION</b>Acupuncture therapy can significantly improve the clinical symptoms, gastroscopic expression and histopathologic situation in the patients of chronic atrophic gastritis, and its therapeutic effect is better than that of the western medicine.</p>

Design of a lithium-ion battery recharging circuit used in wireless electrical stimulation apparatus for urinary incontinence / 中国医疗器械杂志

We introduce in this paper a novel design of the lithium-ion battery automatically-charging circuit used in portable wireless electronic stimulation therapeutic apparatus for urinary incontinence, including its working principles, structure and characteristic.

Randomized controlled study on reinforcing method of acupuncture for treatment of Bell's palsy at restoration stage / 中国针灸

<p><b>OBJECTIVE</b>To observe clinical therapeutic effect of reinforcing method of acupuncture on Bell's palsy at restoration stage.</p><p><b>METHODS</b>One hundred and sixty cases were randomly divided into two groups: an observation group and a control group, 80 cases in each group. The observation group were treated by acupuncture with lifting-thrusting-twirling reinforcing method, and the control group by acupuncture without needling manipulation. The therapeutic effect, and changes of palsy index, degree of palsy and ENoG were observed.</p><p><b>RESULTS</b>Reinforcing method of acupuncture could significantly improve palsy index, degree of palsy and maximal wave amplitude of ENoG; the cured and markedly effective rate was 91.3% in the observation group and 75.0% in the control group with a very significant difference between the two groups (P < 0.01).</p><p><b>CONCLUSION</b>The reinforcing method of acupuncture can increase the therapeutic effect on Bell's palsy at restoration stage.</p>