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Métodos Terapéuticos y Terapias MTCI
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1.
Int Wound J ; 21(4): e14847, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38584331

RESUMEN

Due to the high risks of postoperative complications brought on by gastric cancer, traditional Chinese medicine (TCM) as a commonly used therapy, has exerted its vital role in postoperative recovery care. In this sense, this meta-analysis was conducted to explore the related documents about TCM's impact on gastric cancer postoperative recovery. During the research, we explored a total of 1549 results from databases PubMed, China National Knowledge Infrastructure (CNKI), Embase, Cochrane Library and Web of Science (WoS). Thirty-two clinical randomized trials (RCTs) were then selected and analysed for this meta-analysis by using the software RevMan 5.4 (under PRISMA 2020 regulations), with a population of 3178 patients. Data prove that TCM therapy reduced the risks for postoperative complications exposure by an estimated average of 19% (95% CI). Among the complications, TCM therapy suppressed the risks of wound infection and incisional infections by 53% and 48% respectively. Meanwhile, the patient's wound healing duration exhibited a significant reduction compared to those without TCM treatment, with a difference at around 0.74 days (95% CI). TCM also exerted its potential to strengthen the patient's immune and health conditions, leading to a significantly promoted gastrointestinal function in the patients with a shorter duration to release first exhaustion and defecation compared to those with no TCM therapy. In addition, similar promoted phenomena also exist in those patients with TCM therapy in terms of their immunity and nutritional conditions. These facts all indicate a positive impact of TCM therapy in clinical applications.


Asunto(s)
Medicamentos Herbarios Chinos , Complicaciones Posoperatorias , Neoplasias Gástricas , Humanos , China , Medicamentos Herbarios Chinos/uso terapéutico , Medicina Tradicional China/métodos , Complicaciones Posoperatorias/terapia , Neoplasias Gástricas/tratamiento farmacológico , Neoplasias Gástricas/cirugía
2.
Int Wound J ; 21(2): e14769, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38351506

RESUMEN

Postoperative wound infections (PWIs) pose a significant challenge in colorectal cancer surgeries, leading to prolonged hospital stays and increased morbidity. This systematic review and meta-analysis evaluated the efficacy of the traditional Chinese medicine (TCM) combination of Jie Geng and Huang Qi in reducing PWIs following colorectal cancer surgeries. Adhering to PRISMA guidelines, we focused on seven randomized controlled trials (RCTs) involving 1256 patients, examining the incidence of PWIs within 30 days post-surgery, alongside secondary outcomes such as length of hospital stay and antibiotic use. The analysis revealed a significant reduction in PWI incidence in the TCM-treated group compared to controls, with a Risk Ratio of 0.21 (95% CI: 0.14 to 0.30, p < 0.01), a notable decrease in hospital stay (Mean Difference: 1.2 days, 95% CI: 0.15 to 1.28 days, p < 0.01) and a significant reduction in antibiotic use (Risk Ratio: 0.24, 95% CI: 0.16 to 0.36, p < 0.01). These findings suggest that Jie Geng and Huang Qi in TCM could be an effective adjunct in postoperative care for colorectal cancer surgeries, underscoring the need for further high-quality RCTs to substantiate these results and explore the underlying mechanisms.


Asunto(s)
Neoplasias Colorrectales , Medicamentos Herbarios Chinos , Medicina Tradicional China , Infección de la Herida Quirúrgica , Humanos , Neoplasias Colorrectales/cirugía , Medicamentos Herbarios Chinos/uso terapéutico , Infección de la Herida Quirúrgica/prevención & control , Medicina Tradicional China/métodos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Adulto , Ensayos Clínicos Controlados Aleatorios como Asunto , Anciano de 80 o más Años , Astragalus propinquus
3.
Food Funct ; 10(5): 2906-2913, 2019 May 22.
Artículo en Inglés | MEDLINE | ID: mdl-31070650

RESUMEN

Dysfunction of the intestinal epithelial barrier plays an important role in the pathogenesis of several intestinal diseases, including celiac disease, inflammatory bowel disease, and irritable bowel syndrome. The present research was carried out to investigate the protective effect of total polysaccharides of adlay bran (TPA) on TNF-α-evoked epithelial barrier dysfunction in Caco-2 cells. Caco-2 cells were treated with or without TPA in the absence or presence of TNF-α, and transepithelial electrical resistance (TEER) and Phenol Red flux were assayed to evaluate the intestinal epithelial barrier function. The results indicated that TPA suppressed the TNF-α-induced release of pro-inflammatory factors. Furthermore, TPA obviously assuaged both the increased paracellular permeability and the decrease of TEER in TNF-α-challenged Caco-2 cells. Furthermore, TPA obviously assuaged TNF-α-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-κB p65. Our results indicated that TPA assuages the TNF-α-evoked dysfunction of the intestinal epithelial barrier by inhibiting the NF-κB p65-mediated inflammatory response.


Asunto(s)
Coix/química , Mucosa Intestinal/inmunología , Extractos Vegetales/farmacología , Polisacáridos/farmacología , Factor de Necrosis Tumoral alfa/inmunología , Células CACO-2 , Células Epiteliales/efectos de los fármacos , Células Epiteliales/inmunología , Humanos , Interleucina-6/genética , Interleucina-6/inmunología , Interleucina-8/genética , Interleucina-8/inmunología , Mucosa Intestinal/efectos de los fármacos , Ocludina/genética , Ocludina/inmunología , Fosforilación , Factor de Transcripción ReIA/genética , Factor de Transcripción ReIA/inmunología , Factor de Necrosis Tumoral alfa/genética
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