RESUMEN
AIMS: Diseases caused by pathogenic fungi was a major constrain in increasing productivity and improving quality of Panax notoginseng. The aim of this research was to evaluate the inhibitory activity of essential oils (EOs) from Asteraceae family, Chrysanthemum indicum and Laggera pterodonta, against pathogenic fungi of P. notoginseng. METHODS AND RESULTS: The antifungal activity was investigated using multiple methods, disclosing that the EOs from C. indicum and L. pterodonta are active against hypha growth of different fungi but with different degrees of potency. Checkerboard testing indicated that the combination of EOs with hymexazol had synergistic effect against Pythium aphanidermatum, and exhibited additive effects against bulk of targeted pathogenic fungi. Besides, we found that the baseline sensitivity of Fusarium oxysporum to L. pterodonta EOs was higher than those of C. indicum by means of mycelium growth rate method. Finally, the practicability of those EOs as plant pesticide was confirmed by in vivo model showing that EOs can significantly inhibit the occurrence of root rot of P. notoginseng caused by F. oxysporum. CONCLUSION: Those studies suggest that the EOs from C. indicum and L. pterodonta had the potential to develop into new pollution-free pesticides for the protection of precious Chinese herbal medicines. SIGNIFICANCE AND IMPACT OF THE STUDY: This study provided a new way of biological control for overcoming the frequent diseases occurrence of P. notoginseng.
Asunto(s)
Asteraceae/química , Hongos/efectos de los fármacos , Fungicidas Industriales/farmacología , Aceites Volátiles/farmacología , Panax notoginseng/microbiología , Asteraceae/clasificación , Sinergismo Farmacológico , Hongos/clasificación , Hongos/crecimiento & desarrollo , Hifa/clasificación , Hifa/efectos de los fármacos , Hifa/crecimiento & desarrollo , Oxazoles/farmacología , Enfermedades de las Plantas/microbiología , Enfermedades de las Plantas/prevención & control , Aceites de Plantas/farmacologíaRESUMEN
A new triterpenoid, cucubalugenin A (1), has been isolated from the whole plant of Cucubalus baccifer. Its structure was elucidated by spectral methods.
Asunto(s)
Caryophyllaceae , Fitoterapia , Extractos Vegetales/química , Triterpenos/química , Humanos , Estructuras de las PlantasRESUMEN
In this paper, we report the first stereo-, regio-, and chemo-selective conversion of oridonin from kamebakaurin. The overall yield in 7 steps is 9%.