Asunto(s)
Epidermodisplasia Verruciforme/tratamiento farmacológico , Vacuna Tetravalente Recombinante contra el Virus del Papiloma Humano Tipos 6, 11 , 16, 18/uso terapéutico , Acitretina/uso terapéutico , Adyuvantes Inmunológicos/uso terapéutico , Quimioterapia Combinada , Epidermodisplasia Verruciforme/etiología , Femenino , Humanos , Imiquimod/uso terapéutico , Terapia de Inmunosupresión/efectos adversos , Queratolíticos/uso terapéutico , Trasplante de Riñón , Persona de Mediana Edad , Tretinoina/uso terapéuticoRESUMEN
A 36-year-old man presented with a non-pruritic, erythematous facial rash with peri-oral and peri-orbital sparing. The initial clinicopathological diagnosis was rosacea fulminans, which was treated with 25 mg oral prednisolone and cephalexin. The patient re-presented 1 week later with exacerbation of his rash in addition to constitutional symptoms of fever and malaise. A further skin biopsy was taken and the marked neutrophilic infiltrate in the absence of vasculitis made the diagnosis of Sweet's syndrome (acute febrile neutrophilic dermatosis). High-dose prednisolone (50 mg daily), topical hydrocortisone cream and ichthammol in zinc ointment were commenced with rapid clinical improvement. This case highlights the importance of considering Sweet's syndrome as a differential diagnosis when presented with a facial eruption.