[Treatment and prognosis of primary ocular adnexal extranodal marginal zone mucosa-associated lymphoid tissue lymphoma: a report from a single center].

Objective: This study aimed to see how different initial treatment regimens affected the long-term prognosis of patients with extranodal marginal zone mucosa-associated lymphoid tissue lymphoma confining to the ocular adnexal (OAML) . Methods: Between April 2008 and April 2019, 109 patients with initial mucosa-associated lymphoid tissue confining to ocular adnexal were evaluated and followed-up, and the prognosis of various initial treatment regimens were examined. Results: A total of 36 patients underwent complete surgical resection of the lesions, and 73 patients had residual lesions after surgery, of which 37 patients chose watchful waiting, and 36 patients chose treatment. The treatment regimen included local radiotherapy and systemic treatment (chemotherapy, immunochemotherapy, the combination of radiotherapy and chemotherapy, etc.) , and no serious toxic and side effects were observed in patients receiving systemic treatment. The median follow-up time was 61 (10-142) months. The 5-year and 10-year progression-free survival (PFS) of monocular involvement patients were 78.2% and 76.0% . The 5-year and 10-year PFS rates of patients with binocular involvement were 64.4% and 23.5%. There was significant diference in PFS between patients with monocular and binocular involvement (P=0.010) . Patients who received additional treatment had higher PFS than those patients in the watchful waiting group (P=0.046) . The 5-year PFS was 71.4% and 90.1% among patients in the watchful waiting group and those who received additional treatment, whereas the 10-year PFS was 63.5% and 75.1% , respectively. Patients with OAML were still a risk of disease progression after 5 years. Conclusions: Patients with binocular involvement OAML at the start of the disease had a poor prognosis, but treatment could reduce the risk of recurrence/progression. Systemic therapy is one of the first-line treatment options for patients with OAML, who require long-term monitoring.

Effects of dietary supplementation with carnosine on meat quality and antioxidant capacity in broiler chickens.

1. This study aimed to investigate the effects of carnosine supplementation on meat quality, antioxidant capacity and lipid peroxidation status in broiler chickens. 2. A total of 256 1-d-old male Arbor Acres broilers were randomly assigned to 4 treatments consisting of 8 replicates of 8 chickens each. The birds were supplied with 4 different diets: a basal diet or a basal diet supplemented with 100, 200 or 400 mg/kg carnosine, respectively. The whole experiment lasted 42 d. 3. The results showed that dietary supplementation with carnosine linearly increased the values of pH45 min and redness and reduced drip loss of breast meat. Dietary carnosine increased the activity of antioxidant enzymes in liver, serum and breast meat and decreased the contents of lipid peroxides at 21 and 42 d of age. 4. These findings indicated that dietary supplementation with carnosine was beneficial to enhance meat quality, antioxidant capacity and decrease lipid peroxidation status of breast meat.

Effect of lu-duo-wei on scavenging superoxide and hydroxyl radicals in vitro.

Irradiation of a riboflavin-containing system by ultraviolet light was used to produce superoxide radical (.O2-). Hydroxyl radical (.OH) was generated by the system of Fe(II)-H2O2. Using electron spin resonance and spin trapping techniques, the effect of Lu-Duo-Wei, a capsule consisting extracts of green tea, Fructus Lycii and Semen Ziziphi Spinosae, on scavenging .O2- and .OH was observed. The results showed that the efficiency of scavenging .O2- and .OH by Lu-Duo-Wei was much higher than that by tea polyphenol alone. It is suggested that the synergistic action of tea polyphenol and other components are responsible for the scavenging effect of Lu-Duo-Wei on .O2- and .OH.

[Effect of total flavonoids of radix Astragali on free radical production by myocardial ischemia-reperfusion in rats].

Observation was made on the effect of TFA on FR produced by ischemia-reperfusion in two groups of Langendorff hearts of rats. The result showed that oxygen free radicals were reduced by TFA in myocardial ischemia-reperfusion in rats.