RESUMEN
Allergens play an essential role in atopic dermatitis, either intrinsic or extrinsic. They provoke cutaneous inflammation via IgE-dependent and cell-mediated immune reactions. Food allergens have a well-known contribution to disease activity of atopic dermatitis, especially in infants and young children. However, the importance of inhaled allergens is still under investigation. For clinical implication, identification of individualized allergens is an ideal strategy for better control of atopic dermatitis and avoidance of atopic march. The aim of this article is to discuss the common allergens in atopic dermatitis (AD), the specificity and sensitivity of laboratory tests for allergens, and the clinical effect of various preventions.
Asunto(s)
Alérgenos , Dermatitis Atópica/inmunología , Hipersensibilidad Respiratoria/inmunología , Niño , Preescolar , Dermatitis Atópica/sangre , Dermatitis Atópica/diagnóstico , Dermatitis Atópica/terapia , Dermatitis por Contacto/sangre , Dermatitis por Contacto/diagnóstico , Dermatitis por Contacto/prevención & control , Dietoterapia , Polvo/inmunología , Femenino , Hipersensibilidad a los Alimentos/sangre , Hipersensibilidad a los Alimentos/inmunología , Humanos , Inmunidad Celular , Inmunoglobulina E/sangre , Lactante , Recién Nacido , Intercambio Materno-Fetal , Pruebas del Parche , Polen/inmunología , Embarazo , Hipersensibilidad Respiratoria/sangre , Hipersensibilidad Respiratoria/diagnóstico , Hipersensibilidad Respiratoria/prevención & controlRESUMEN
Radiation injury to the skin is one of the major limiting factors in radiotherapy. We designed this study using Sprague-Dawley rats to evaluate the reduction in skin injury achieved using natural products from plant extracts as protection. The acute skin reaction in tetrandrine- and Madecassol-treated animals appeared earlier, but was significantly less severe, than in the control group. The peak skin reactions in the tetrandrine group were less serious than those of the control group at three different radiation doses. At a high dose irradiation, the healing effect of tetrandrine is better than Madecassol and vaseline. The histologic findings indicate that tetrandrine and Madecassol are able to reduce acute radiation reactions by their anti-inflammatory activity.