1.
Nucleosides Nucleotides Nucleic Acids
; 23(12): 1929-37, 2004.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15628749
RESUMEN
Synthesis of phosphoramidate protides of carbocyclic D- and L-2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine by treatment of the nucleoside with phosphorochloridates in the presence of pyridine and t-BuMgCl is described. Several of these protides showed significantly improved antiviral potency over the parent nucleosides against both HIV and HBV.