Asunto(s)
Bromelaínas/uso terapéutico , Colágenos no Fibrilares/efectos de los fármacos , Penfigoide Ampolloso/tratamiento farmacológico , Penfigoide Ampolloso/inmunología , Proteolisis/efectos de los fármacos , Autoantígenos/inmunología , Biopsia con Aguja , Células Cultivadas , Humanos , Inmunohistoquímica , Penfigoide Ampolloso/patología , Muestreo , Índice de Severidad de la EnfermedadAsunto(s)
Fármacos Dermatológicos/uso terapéutico , Linfoma Cutáneo de Células T , Terapia PUVA/métodos , Radioterapia/métodos , Neoplasias Cutáneas , Piel/patología , Anciano , Antígenos de Diferenciación de Linfocitos T/análisis , Atrofia , Diagnóstico Diferencial , Manejo de la Enfermedad , Humanos , Linfoma Cutáneo de Células T/diagnóstico , Linfoma Cutáneo de Células T/inmunología , Linfoma Cutáneo de Células T/patología , Linfoma Cutáneo de Células T/terapia , Masculino , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapiaRESUMEN
An 18-year-old black woman with cerebral palsy was admitted for evaluation of an intrathecal baclofen pump site infection. The dermatology service was consulted for treatment suggestions of a presumed diagnosis of chronic tinea capitis. Three courses of oral griseofulvin during the past 2 years failed to resolve the patient's chronic scalp dermatosis. Scalp lesions first began about 2 years earlier after hospitalization for placement of an intrathecal baclofen pump. The patient was unable to care for her scalp due to her cerebral palsy, and her mother interpreted the scalp condition as infectious. No routine shampoo care, scalp care, or topical treatment was performed for more than 1 1/2 years. The mother felt that touching the patient's scalp might cause pain and noted that the majority of her time was spent concentrating on more critical medical issues. Physical examination revealed coalescing hyperkeratotic plaques extending dorsally from the anterior hairline to the occipital scalp with small flecks of keratinous debris throughout the remaining hair (Figure 1). The plate-like plaques were devoid of hair, except at a few fissures where a few tufts of hair emerged. No cervical lymph nodes were appreciated on palpation. Treatment was initiated with compresses consisting of large warm water-soaked towels 4 times daily. Three times a day, a nursing staff applied 5% salicylic acid in olive oil to the scalp under a shower cap for approximately 1 hour. Over the following 2 days, a significant reduction in keratinous debris was appreciated. Within 2 weeks, the bulk of the plaques had been removed (Figure 2). At 6-week follow-up, the underlying scalp showed areas of fibrosis and possible scarring with a few emerging tufts of hair. On the basis of history and response to treatment with salicylic acid and routine scalp care, the patient was diagnosed with an unusually severe case of dermatosis neglecta.