Asunto(s)
Cloraminas/análisis , Soluciones para Diálisis/química , Eritropoyetina/uso terapéutico , Diálisis Renal , Algoritmos , Anemia/prevención & control , Carbón Orgánico , Estudios de Cohortes , Relación Dosis-Respuesta a Droga , Resistencia a Medicamentos , Eritropoyetina/administración & dosificación , Filtración , Hemoglobinas/análisis , Humanos , Hierro/uso terapéutico , Diálisis Renal/efectos adversos , Terapia Asistida por Computador , Agua/químicaRESUMEN
The vitamin status (vitamins A, E, C, Carotene, B1, B2 and B6) of 18 patients receiving maintenance haemodialysis was assessed. All patients were receiving vitamin B1, B2 and B6 supplements and the effect of stopping these supplements on subsequent vitamin status was further studied. Apart from vitamin A, which was significantly increased in all patients, the mean level of all other vitamins was similar to the control group. Despite these normal group means, individual patients could be identified with low or marginally low vitamin C and B2 levels. When the vitamin B complex supplements were stopped, vitamin B2 and B6 remained normal over the subsequent six months maintenance haemodialysis but there was deterioration in vitamin B2 status. Leucocyte vitamin C levels responded well to oral supplements of 400 mg vitamin C per day. This study suggests that vitamin C and B2 supplements are necessary in patients receiving maintenance haemodialysis, other vitamin supplements being unnecessary.
Asunto(s)
Avitaminosis/epidemiología , Diálisis Renal , Femenino , Humanos , Masculino , Vitaminas/administración & dosificación , Vitaminas/sangreRESUMEN
After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation and causes significant malabsorption of calcium and phosphorus even though good graft function is established. Calcium and phosphorus malabsorption can be improved by exogenous 1,25-dihydroxy vitamin D (oral 1 alpha-OH D3 or 1,25-[OH]2D3).
Asunto(s)
Calcio/metabolismo , Tasa de Filtración Glomerular , Absorción Intestinal , Trasplante de Riñón , Fósforo/metabolismo , Prednisona/efectos adversos , Adolescente , Adulto , Humanos , Absorción Intestinal/efectos de los fármacos , Fallo Renal Crónico/metabolismo , Masculino , Persona de Mediana Edad , Trasplante HomólogoRESUMEN
Thirteen patients with the nephrotic syndrome were treated with a high-protein diet, a 0.5 g sodium intake (equivalent to 1.3 g sodium chloride), and frusemide in increasing dosage. One became oedema-free with frusemide 240 mg daily, three became oedema-free with frusemide 500 mg daily, and two required a combination of high-dose frusemide and spironolactone. In three there was an appreciable increase in the blood urea, one patient developed hyponatraemia, and in two there was no weight loss. In these six patients infusions of human salt-poor albumin produced a prompt diuresis, loss of weight, and correction of the abnormal biochemical findings. In the seventh severely oedematous patient combined albumin and diuretic therapy led to a loss of 27 kg in 14 days.