1.
Bioorg Med Chem Lett
; 20(17): 5104-7, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20678932
RESUMEN
Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide.