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1.
J Stroke Cerebrovasc Dis ; 33(6): 107718, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38604352

RESUMEN

INTRODUCTION: Post stroke cognitive impairment (PSCI) is a common complication of ischemic stroke. PSCI can involve different depending on clinical and stroke related characteristics. The aim of this study is to determine the factors associated with impairments in specific cognitive domains. METHODS: The Vitamins to Prevent Stroke (VITATOPS) trial is a large, multinational randomised controlled trial. In this substudy, consecutive patients admitted for ischaemic stroke or transient ischaemic attack (TIA) at a tertiary hospital in Singapore were included. PSCI was defined as impairment of any of the six cognitive subgroups - visuoconstruction, attention, verbal memory, language, visual memory and visuomotor function - that were assessed annually for up to five years. Univariate and multivariate Cox proportional hazard models were used to determine factors associated with impairments in each of these cognitive domains. RESULTS: A total of 736 patients were included in this study, of which 173 (23.5 %) developed cognitive impairment. Out of the six cognitive domains, the greatest proportion of patients had an impairment in visuoconstruction (26.4 %) followed by attention (19.8 %), verbal memory (18.3 %), language (17.5 %), visual memory (17.3 %) and visuomotor function (14.8 %). Patients with posterior circulation cerebral infarction (POCI) as the index stroke subtype had higher rates of cognitive impairment. Further subgroup analyses show that Indian race and advanced age were predictive of language impairment, whilst fewer years of education and POCI were predictive of verbal memory impairment. POCI was predictive of visual memory impairment, and advanced age and POCI were predictive of visuomotor function impairment. CONCLUSION: We identified visuoconstruction and attention domains to be the most affected in our Asian cohort of PSCI. Advanced age, lower levels of education, posterior circulation strokes and concomitant comorbidities such as peripheral artery disease are independent predictors of PSCI.


Asunto(s)
Cognición , Disfunción Cognitiva , Humanos , Masculino , Femenino , Anciano , Persona de Mediana Edad , Singapur/epidemiología , Factores de Riesgo , Disfunción Cognitiva/diagnóstico , Disfunción Cognitiva/etiología , Disfunción Cognitiva/epidemiología , Factores de Tiempo , Memoria , Medición de Riesgo , Pronóstico , Accidente Cerebrovascular Isquémico/diagnóstico , Accidente Cerebrovascular Isquémico/epidemiología , Pruebas Neuropsicológicas , Atención , Accidente Cerebrovascular/diagnóstico , Accidente Cerebrovascular/complicaciones , Ataque Isquémico Transitorio/diagnóstico , Ataque Isquémico Transitorio/complicaciones , Ataque Isquémico Transitorio/psicología
2.
Int J Stroke ; 18(2): 163-172, 2023 02.
Artículo en Inglés | MEDLINE | ID: mdl-35195052

RESUMEN

BACKGROUND AND PURPOSE: A third of stroke patients suffer from post-stroke cognitive decline, depressive symptoms, and anxiety symptoms. B-vitamin supplementation provides a possible safe and affordable treatment to mitigate post-stroke neuropsychiatric sequelae via reducing homocysteine levels. Our study aims to examine the effect of B-vitamin supplementation in the prevention of post-stroke cognitive decline, depressive symptoms, and anxiety symptoms. Our secondary aims were to investigate associations between baseline factors and the three outcomes. METHODS: Patients were recruited as part of a Singaporean substudy of a randomized controlled trial that examined the effect of B-vitamin supplementation on recurrent cardiovascular events. Cognitive decline, depressive symptoms, and anxiety symptoms were assessed with neuropsychological assessments and Hospital Anxiety and Depression Scale 6 monthly. Cox regression analyses were performed to determine treatment efficacy. Logistic regression used to examine factors associated with cognitive decline, depressive symptoms, and anxiety symptoms. RESULTS: A total of 707 were included in the analyses. Survival and hazards ratio analysis showed no treatment effect of B-vitamins on cognitive decline, depressive symptoms, and anxiety symptoms. Cognitive decline was only associated with age. Depressive symptoms were associated with large anterior cerebral infarcts and hyperlipidemia. CONCLUSIONS: Our study showed no benefit of supplementation with B-vitamins for post-stroke cognitive decline, depressive symptoms, or anxiety symptoms. Depressive symptoms were associated with larger anterior cerebral infarcts, which may be reflective of the disability associated with larger infarcts.


Asunto(s)
Trastornos del Conocimiento , Accidente Cerebrovascular , Complejo Vitamínico B , Humanos , Complejo Vitamínico B/uso terapéutico , Complejo Vitamínico B/farmacología , Trastornos del Conocimiento/prevención & control , Accidente Cerebrovascular/complicaciones , Cognición , Suplementos Dietéticos , Infarto Cerebral
3.
J Stroke Cerebrovasc Dis ; 29(9): 105009, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32807424

RESUMEN

BACKGROUND: Acute stroke unit (ASU) care is proven to reduce mortality and morbidity. During the COVID-19 crisis, established physical units and care practices within existing physical units are likely to be disrupted. Stroke patients with possible suspected COVID-19 infection may be isolated in other wards outside the ASU. METHODS: Our hospital developed an adapted ASU protocol which includes key elements for stroke unit care, can be utilized by staff not familiar with stroke care with minimal training and can be implemented in various settings. RESULTS: The adapted protocol has 3 categories of Acute monitoring (neurological observations, blood pressure and input-output monitoring, investigations and specific post-reperfusion issues), Stroke complications (focusing on 5 common complications) and Unified team (describing daily check-ins, patient education, communication, discharge planning and post-discharge support). CONCLUSIONS: Details are presented in the article in a format that it can be adopted by other centers facing similar issues in order to ensure ASU care is not compromised.


Asunto(s)
Protocolos Clínicos , Continuidad de la Atención al Paciente/organización & administración , Infecciones por Coronavirus/terapia , Prestación Integrada de Atención de Salud/organización & administración , Grupo de Atención al Paciente/organización & administración , Neumonía Viral/terapia , Accidente Cerebrovascular/terapia , COVID-19 , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Humanos , Salud Laboral , Pandemias , Seguridad del Paciente , Neumonía Viral/diagnóstico , Neumonía Viral/transmisión , Neumonía Viral/virología , Desarrollo de Programa , Evaluación de Programas y Proyectos de Salud , Factores de Riesgo , Singapur , Accidente Cerebrovascular/diagnóstico , Accidente Cerebrovascular/fisiopatología
4.
J Clin Neurosci ; 33: 269-270, 2016 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-27469414

RESUMEN

In the randomized controlled trial of NeuroAiD versus placebo following ischemic stroke, there was a trend for sex influencing the treatment effect of NeuroAiD in improving functional outcome following ischemic stroke (p=0.075).


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Caracteres Sexuales , Accidente Cerebrovascular/tratamiento farmacológico , Anciano , Método Doble Ciego , Femenino , Humanos , Masculino , Resultado del Tratamiento
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