RESUMEN
The aim of this study was to investigate the influence of a small amount of enteral nutrition along with parenteral nutrition on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats in the early phase of disease. The induction of ANP resulted in a significant increase in mortality rate, intestinal permeability, bacterial infection in the pancreas and extrapancreatic organs, pancreatic necrosis and serum activity of urea and amylase, and a significant decrease in concentrations of calcium, protein and albumin. But no difference was observed between the pancreatitis groups. Significant hyperglycemia and increased liver transaminase activity were observed in rats treated with combined nutritional therapy (CNT). CNT did not improve the course of acute pancreatitis, intestinal permeability, bacterial translocation, or reduce the extent of acinar cell injury in ANP and is therefore unlikely to be of benefit in patients with pancreatitis in the early period.
Asunto(s)
Terapia Nutricional , Pancreatitis Aguda Necrotizante/terapia , Animales , Infecciones Bacterianas/epidemiología , Infecciones Bacterianas/etiología , Traslocación Bacteriana , Supervivencia Celular , Detergentes , Nutrición Enteral , Ácido Glicodesoxicólico , Incidencia , Mucosa Intestinal/metabolismo , Masculino , Mortalidad , Páncreas/metabolismo , Páncreas/microbiología , Páncreas/patología , Páncreas/fisiopatología , Pancreatitis Aguda Necrotizante/inducido químicamente , Pancreatitis Aguda Necrotizante/complicaciones , Pancreatitis Aguda Necrotizante/fisiopatología , Nutrición Parenteral , Permeabilidad , Ratas , Ratas Sprague-Dawley , Insuficiencia del TratamientoRESUMEN
The present study was carried out to determine polymorphonuclear (PMN) elastase levels and to explain whether or not altered levels may be a factor in depression. The patient group included a total of 68 patients with depression (32 with major depression, 36 with dysthymia). The control group included 40 volunteer, healthy subjects. WBC, erythrocyte sedimentation rate (ESR), immunogloblins (Ig A, IG G, IgM), and complements (C3 and C4) levels of the patient and control groups were determined. The mean PMN elastase levels, determined by immunoactivation method, in patients with major depression without and with melancholia, dysthymia and healthy subjects were found to be 99.5 (10.8) microgram(s)/L [arithmetic mean (SEM)], 289.0 (71.3) microgram(s)/L, 55.7(5.5) microgram(s)/L, and (47.3(2.6) microgram(s)/L, respectively. The mean PMN elastase level was found to be statistically higher in patients with depression, especially in patients with major depression, than that of healthy subjects. It was concluded that severe depression is associated with immunological and inflammatory alterations may be showed easily by PMN elastase measurements.