RESUMEN
Experimental data indicated that Acanthopanax giraldii given intraperitoneally in mice had pronounced inhibitory effects on the CNS. It reduced the spontaneous activity, prolonged the hypnotic time of pentobarbital sodium and antagonised the amphetamine-induced hyperactivity. The results suggest that the sedative effect of A. giraldii is probably different from that of diazepam, but perhaps similar to that of reserpine.
Asunto(s)
Sistema Nervioso Central/efectos de los fármacos , Medicamentos Herbarios Chinos/farmacología , Anfetamina/antagonistas & inhibidores , Animales , Ansiolíticos/farmacología , Encéfalo/metabolismo , Medicamentos Herbarios Chinos/toxicidad , Femenino , Dosificación Letal Mediana , Masculino , Ratones , Actividad Motora/efectos de los fármacos , Convulsiones/inducido químicamente , Convulsiones/tratamiento farmacológico , Serotonina/metabolismo , Sueño/efectos de los fármacosRESUMEN
Experimental data indicate that EtOH extract of Acanthopanax giraldii (EAGH) has pronounced analgesic action and reduces not only high temperature induced by proteinic jelly, but also normal body temperature in rabbits. However no effect was observed on the fever induced by choleraic vaccine in rabbits. The acute ip LD50 of EAGH in mice was 73.34 +/- 7.29 g/kg (crude drug). In prolonged toxicity test on rats no harmful effects on body weight, blood picture, liver and kidney functions were observed.
Asunto(s)
Antiinflamatorios no Esteroideos/farmacología , Temperatura Corporal/efectos de los fármacos , Medicamentos Herbarios Chinos/farmacología , Fiebre/tratamiento farmacológico , Umbral del Dolor/efectos de los fármacos , Animales , Antiinflamatorios no Esteroideos/uso terapéutico , Antiinflamatorios no Esteroideos/toxicidad , Vacunas contra el Cólera , Medicamentos Herbarios Chinos/uso terapéutico , Medicamentos Herbarios Chinos/toxicidad , Femenino , Fiebre/etiología , Masculino , Ratones , Conejos , Distribución Aleatoria , RatasRESUMEN
The results of the experiments indicate that the prostatic hyperplasia caused by Testosteroni Propionatis in mice, cotton oil-induced local swollen ears of mice and the proliferation of granuloma produced by subcutaneous implantation of cotton pill in rats are inhibited significantly by the preparation of Xiao Long Ling. Xiao Long Ling depresses the increase of vascular permeability induced by a variety of inflammatory media such as histamine, 5-HT and PGE. Xiao Long Ling is found capable of inhibiting the platelet aggregation induced by ADP as well as depolymerizing the aggregated platelets.