[Relationship between liver fibrosis criteria and syndrome-type of TCM in patients with non-alcoholic fatty liver].

OBJECTIVE: To explore the relationship between the liver fibrosis criteria and TCM Syndrome, type in the patients suffering from non-alcoholic fatty liver. METHODS: Seventy-nine patients with non-alcoholic fatty liver diagnosed by B ultrasonography were classified by TCM Syndrome Differentiation and their liver fibrosis criteria was determined and compared with those of the health subjects as control. RESULTS: Levels of procollagen III (PCIII), hyaluronic acid (HA), collagen IV (CIV) and laminin (LN) in the fatty liver group were significantly higher than those in the control group (P < 0.05, P < 0.01). In respect to the TCM Syndrome-types, PCIII, CIV and LN in patients of Phlegm-stasis combined type were significantly higher than those in patients of other two Syndrome-types (P < 0.05, P < 0.01), while HA was insignificantly different (P > 0.05). CONCLUSION: There was trend of liver fibrosis in fatty liver patients. It was indicated that the Phlegm-stasis combined Syndrome-type possibly was the main TCM pathologic factor of the increasing of fibrosis criteria for non-alcoholic fatty liver.

[Correlation between serum adenosine deaminase, peripheral T lymphocyte subsets and syndrome types of traditional Chinese medicine in liver-cirrhosis patients].

Serum adenosine deaminase (ADA) of 74 liver cirrhosis patients and 100 healthy subjects as control were examined with improved Martinek microassay and peripheral T lymphocyte subsets of 38 liver cirrhosis patients and 60 healthy subjects studied by indirect immunofluorescence assay (IFA) for exploring the relationship between them and syndrome types of TCM. The result showed that level of ADA of liver cirrhosis patients was higher than that of control (P < 0.01) and increased in following order: the type of Liver-energy Depression and Spleen Deficiency, that of Heat-Stagnation and Blood Stasis and that of Yin-Deficiency and Microvessel Obstruction. The difference of serum ADA among the types were significant (P < 0.01). The result also showed that OKT8 of liver cirrhosis patients was higher, the ratio of OKT4/OKT8 was lower than the healthy subjects (P < 0.05-0.01), but the difference among the types were not significant (P > 0.05). Serum ADA seemed to be one of the reference indexes in differentiating syndrome types of TCM, determining the patient's condition and prognosis.