RESUMEN
Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.
Asunto(s)
Antiulcerosos/farmacología , Artemisininas , Asteraceae , Sesquiterpenos/farmacología , Úlcera Gástrica/tratamiento farmacológico , Estómago/efectos de los fármacos , Animales , Antiulcerosos/química , Antiulcerosos/uso terapéutico , Carbenoxolona/farmacología , Cimetidina/farmacología , Interacciones Farmacológicas , Etanol/administración & dosificación , Indometacina/administración & dosificación , Masculino , Fitoterapia , Extractos Vegetales/química , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico , Ratas , Ratas Wistar , Sesquiterpenos/química , Sesquiterpenos/aislamiento & purificación , Sesquiterpenos/uso terapéutico , Estómago/patología , Úlcera Gástrica/inducido químicamenteRESUMEN
O extrato fluido de algodäozinho-do-campo - Cochlospermum regium (Mart. et Schr.) Pilger foi avaliado farmacológicamente, realizando-se testes de toxicidade aguda, determinaçäo da DL50 em camundongos e testes de atividade anti-edematogênica e anti-ulcerogênica deste extrato liofilizado.