RESUMEN
Two unknown enantiomeric compounds, named (R)- and (S)-taeniolin, along with six known compounds, were isolated from the marine-associated fungus Taeniolella sp. BCC31839. Chemical structures were determined by NMR spectroscopic techniques, and the absolute configurations were confirmed by Mosher application together with CD spectral analyses. Both were inactive for antimicrobial activity against multidrug-resistant malaria parasite (Plasmodium falciparum) and bacteria (Mycobacerium tuberculosis and Bacillus cereus) at maximum tested concentration.
Asunto(s)
Antibacterianos/farmacología , Antimaláricos/farmacología , Cromonas/química , Hongos Mitospóricos/química , Animales , Antibacterianos/química , Antimaláricos/química , Antineoplásicos/química , Antineoplásicos/farmacología , Bacillus cereus/efectos de los fármacos , Chlorocebus aethiops , Cromonas/farmacología , Dicroismo Circular , Evaluación Preclínica de Medicamentos , Humanos , Células MCF-7 , Espectroscopía de Resonancia Magnética , Hongos Mitospóricos/aislamiento & purificación , Estructura Molecular , Mycobacterium tuberculosis/efectos de los fármacos , Plasmodium falciparum/efectos de los fármacos , Células VeroRESUMEN
Fourteen new compounds including thirteen drimane - phthalide derivatives (fendlerals A - C, fendlerins A - D, fendlerols A - B, fendleric acids A - C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C - D, fendleryls C - D, atromentin, tetramethyl atromentin, and (±)-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane - phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39⯵M), Colletotrichum capsici (MIC 6.25-12.5⯵g/mL), and Bacillus cereus (MIC 1.56-3.13⯵g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.
Asunto(s)
Antiinfecciosos/farmacología , Antineoplásicos/farmacología , Benzofuranos/farmacología , Sesquiterpenos/farmacología , Xylariales/química , Animales , Antiinfecciosos/aislamiento & purificación , Antineoplásicos/aislamiento & purificación , Bacillus cereus/efectos de los fármacos , Benzofuranos/aislamiento & purificación , Línea Celular Tumoral , Chlorocebus aethiops , Humanos , Estructura Molecular , Plasmodium falciparum/efectos de los fármacos , Sesquiterpenos Policíclicos , Sesquiterpenos/aislamiento & purificación , Tailandia , Células VeroRESUMEN
Eleven substances including naphthalenones, naphthoquinones, unsymmetrical naphthoquinone dimers and a chlorinated diphenyl ether, three of which are new, have been isolated from the fungus Phaeosphaeria sp. The absolute stereochemistry of naphthalenones has been determined by the Mosher and exciton chirality methods. The biological activity of these compounds against Mycobacterium tuberculosis and cytotoxicity against KB, BCA, NCI-H 187 and Vero cell lines were evaluated.