[The technology for manufacturing antiparasitic preparations. 3. The development of a technology for producing the anthelmintic embovin (pyrantel embonate) in finely dispersed form and the evaluation of its anthelmintic properties]. / Tekhnologiia proizvodstva protivoparazitarnykh preparatov. 3. Razrabotka tekhnologii polucheniia antigel'mintika émbovina (pirantelia émbonata) v melkodispersnoi forme i otsenka ego protivogel'mintnykh svoistv.

Manufacturing process for anthelmintic embovin in a micronized form have been developed. Embovin in the micronized form exhibited the highest activity.

[The technology for manufacturing antiparasitic preparations. 1. The development of a technology for producing the anthelmintic triklazan in finely dispersed form and the evaluation of its antinematodal, anticestodal and antitrematodal activities]. / Tekhnologiia proizvodstva protivoparazitarnykh preparatov. Soobshchenie 1. Razrabotka tekhnologii polucheniia antigel'mintika triklazana v melkodispersnoi forme i otsenka ego protivonematodnoi, protivotsestodnoi i protivotrematodnoi aktivnosti.

The authors describe the technology of preparing a new anthelmintic agent triclazan, N-(3,4-dichlorophenyl)-2-[(benzo-2,1,3-thiadiazole-4-sulfonyl)amino]-5- chlorobenzamide, finely dispersed (the particles size 4-8 mu). Triclazan is highly effective not only in hymenolepiasis and trichocephaliasis, as was shown previously, but in fascioliasis, monieziasis and intestinal nematodiasis of sheep as well.

[The search for new antiparasitic agents. 9. The anthelmintic activity of halogen-containing sulfonamidobenzamides]. / Izyskanie novykh protivoparazitarnykh sredstv. 9. Protivogel'mintnaia aktivnost' galoidsoderzhashchikh sul'fonamidobenzamidov.

The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.