RESUMEN
In 2012, intramuscular midazolam appears as effective as intravenous lorezepam for the first line treatment of convulsive status epilepticus. Perampanel, a new anti-epileptic drug, will be soon available. Two oral treatments are now available for stroke prevention in atrial fibrillation setting. The methylphenidate and the Tai Chi could increase the walk capacity of patients suffering from Parkinson disease. A comprehensive cardiac work-up is essential for some congenital myopathy. A new drug against migraine seems free from vasoconstrictive effect. Antioxidants are harmful in Alzheimer disease. Some oral medication will be available for multiple sclerosis.
Asunto(s)
Neurología/tendencias , Anticonvulsivantes/uso terapéutico , Trastornos Cerebrovasculares/terapia , Demencia/terapia , Discinesias/terapia , Epilepsia/tratamiento farmacológico , Humanos , Trastornos Mentales/terapia , Neuroinmunomodulación/fisiología , Neurología/métodos , Enfermedades Neuromusculares/terapia , Terapias en Investigación/métodos , Terapias en Investigación/tendenciasRESUMEN
The authors observed a patient after he had ischemic strokes in both paramedian thalamic regions, which were more marked on the left side. Symptoms included dysphasia, vertical binocular diplopia, right-sided hemianopia, and a right-sided sensory and motor deficit, sparing the face. However, the most disturbing phenomenon was a painless, left monocular dazzle, which was the presenting symptom and also the only persisting symptom. This report shows that a thalamic lesion may be at the origin of central dazzle, and to the authors' knowledge, it is the first clinical observation of its monocular occurrence. It is conceivable that this dazzle was due to optic-trigeminal summation.
Asunto(s)
Infarto Encefálico/complicaciones , Enfermedades Talámicas/complicaciones , Tálamo/patología , Trastornos de la Visión/etiología , Visión Monocular , Infarto Encefálico/diagnóstico , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Enfermedades Talámicas/diagnósticoRESUMEN
The authors observed a periodic downbeat nystagmus with a cycle of 3 minutes 30 seconds, beating downward for a period of 90 seconds every 2 minutes. It lasted 86 hours in a patient with severe hypomagnesemia associated with complications from scleroderma. There was no lesion on brain imaging, and an EEG performed during the nystagmus was normal, indicating that the most likely explanation for this periodic nystagmus is metabolic. This form of nystagmus may have resulted from severe hypomagnesemia, possibly associated with thiamine deficiency.