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1.
J Clin Gastroenterol ; 56(10): 869-874, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-34334763

RESUMEN

GOAL: The aim of this study was to survey adults with celiac disease (CD) on the utility of specific aspects of follow-up and on information needs. BACKGROUND: Currently, the treatment for CD is strict gluten avoidance. Although this places the onus on the patient for disease management, patient perspectives on CD care have not been formally assessed. STUDY: The Manitoba Celiac Disease Cohort prospectively enrolled adults newly diagnosed with CD using serology and histology. At the 24-month study visits, participants rated the utility of aspects of CD care on a 5-point scale anchored by "not at all useful" and "very useful" and the helpfulness of information on CD-related topics on a 6-point scale anchored by "not at all helpful" and "very helpful." RESULTS: The online survey was completed by 149 of 211 cohort members [median age 40 (interquartile range 30 to 56) y; 68% female]. Adherence to a gluten-free diet was good. Most participants (87%) responded that they should be seen regularly for medical follow-up of CD, preferably every 6 (26%) or 12 months (48%). Blood tests were the most highly rated care component (rated scored ≥4/5 by 78% of respondents), followed by the opportunity to ask about vitamins and supplements (50%), symptom review (47%), and information on CD research (44%). Diet review was not considered helpful. CONCLUSIONS: Two years after diagnosis, most individuals with CD find regular specialist follow-up helpful, particularly for biochemical assessment of disease activity and its complications. Furthermore, information on research and long-term complications of CD is also valued.


Asunto(s)
Enfermedad Celíaca , Adulto , Enfermedad Celíaca/complicaciones , Enfermedad Celíaca/diagnóstico , Enfermedad Celíaca/terapia , Dieta Sin Gluten , Femenino , Glútenes , Humanos , Masculino , Cooperación del Paciente , Encuestas y Cuestionarios , Vitaminas
2.
Clin Nutr ; 40(7): 4616-4623, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-34229267

RESUMEN

BACKGROUND & AIMS: Mixed oil intravenous lipid emulsion (MO ILE) that contains 30% soybean oil (SO), 30% medium chain triglycerides, 25% olive oil and 15% fish oil can benefit hospitalized patients receiving parenteral nutrition (PN) but there are very few studies on its long-term use. Our goal was to evaluate the clinical outcomes of adults receiving home PN (HPN) with MO versus those receiving SO ILE over a 2-year period. METHOD: This is a retrospective analysis of data collected prospectively from a cohort of patients recorded in the Canadian HPN Registry over a 2-year period. HPN patients from academic programs across Canada were entered in the Registry according to a validated protocol. For this study, demographic, nutritional, laboratory and clinical data were extracted from January 1st 2015, when MO lipid emulsion became available in Canada, to July 24th 2019. Clinical data for each patient included: number of hospitalizations, number of hospitalizations related to HPN and number of hospitalization days related to HPN, over a year; incidence of line sepsis per 1000 catheter days and mortality. Data are presented as median (1st, 3rd quartile) for continuous variables and frequency (percentage) for categorical variables. Comparisons between groups were performed using two sample t-test or Wilcoxon Rank Sum tests for continuous variables and Chi-square tests or Fisher's exact tests for categorical variables. Univariate and multiple linear regressions were also carried out. Statistical significance is set at a p-value <0.05. RESULTS: A total of 120 patients were included (MO n = 68, SO n = 52). Significant differences at baseline between the two groups were a higher use of Hickman line (62.12% vs 42%, p = 0.038) and more western Canada based hospital care with MO (75% vs 42.31%, p = 0.0002). The MO group had significantly more hospitalizations (p = 0.001), more hospitalizations related to HPN (p = 0.012) and more hospitalization days related to HPN (p = 0.016) per patient per year compared to SO patients. There was no significant difference between groups for line sepsis per 1000 catheter days (MO: 0.05 (0.0, 1.0) vs SO: 0.0 (0.0, 0.22), p = 0.053) or mortality. All other variables, including biochemical variables, were similar between groups. In a multiple regression analysis, the following factors were significantly associated with a greater number of hospitalizations per patient per year: use of MO, high blood glucose from the last recorded value and having died by the end of the study period. CONCLUSION: This 2-year prospective cohort study suggests an increased risk of hospitalization in HPN patients receiving MO lipid emulsion. The long-term effect of using MO lipid emulsion in HPN patients should be further evaluated using a large randomized controlled trial. THE STUDY WAS REGISTERED IN CLINICALTRIALS.GOV: (NCT02299466).


Asunto(s)
Grasas de la Dieta/efectos adversos , Emulsiones Grasas Intravenosas/efectos adversos , Hospitalización/estadística & datos numéricos , Nutrición Parenteral en el Domicilio/estadística & datos numéricos , Aceite de Soja/efectos adversos , Adulto , Canadá , Grasas de la Dieta/administración & dosificación , Emulsiones Grasas Intravenosas/química , Femenino , Aceites de Pescado/administración & dosificación , Enfermedades Gastrointestinales/terapia , Neoplasias Gastrointestinales/terapia , Humanos , Masculino , Persona de Mediana Edad , Aceite de Oliva/administración & dosificación , Nutrición Parenteral en el Domicilio/métodos , Estudios Prospectivos , Sistema de Registros , Estudios Retrospectivos , Síndrome del Intestino Corto/terapia , Aceite de Soja/administración & dosificación , Triglicéridos/administración & dosificación
3.
Br J Nutr ; 126(5): 738-746, 2021 09 14.
Artículo en Inglés | MEDLINE | ID: mdl-33172514

RESUMEN

Adherence to a gluten-free diet (GFD) is the only available treatment for gluten-related disorders, although a GFD may also be followed for discretionary reasons. The main objectives of the present study were to (1) describe and test for differences in key nutrient intakes among Canadians who follow a GFD compared with Canadians with no dietary exclusions and (2) describe additional dietary avoidances adhered to by Canadians who avoid gluten. We conducted a secondary analysis of the cross-sectional 2015 Canadian Community Health Survey-Nutrition Survey, which included a general health survey and 24-h dietary recall (n 20 487). Participants were categorised as those who avoid dietary gluten and those who reported no avoidances. Key nutrient intakes were assessed, as a percentage of Dietary Recommended Intakes, including fibre, B vitamins, vitamin D, Ca, Fe, Na and Zn, and compared between the two groups using t tests. Canadians who avoided gluten had significantly lower intakes of folate, vitamin B12, vitamin D, Fe, Na and Ca compared with those who did not avoid any food groups. However, Canadians who reported following a GFD were significantly more likely to use vitamin or mineral supplements in the past 30 d. More than 20 % of those who avoided gluten also avoided dairy products. Findings suggest that following a GFD places Canadians at risk for nutrient inadequacies, particularly folate, Ca and vitamin D. Further research is required to further examine how multiple dietary avoidances among those who avoid gluten may contribute to dietary inadequacies.


Asunto(s)
Dieta Sin Gluten , Estado Nutricional , Ingesta Diaria Recomendada , Canadá , Estudios Transversales , Suplementos Dietéticos , Ácido Fólico , Glútenes , Encuestas Epidemiológicas , Humanos , Encuestas Nutricionales , Complejo Vitamínico B , Vitamina D
4.
JPEN J Parenter Enteral Nutr ; 45(4): 670-684, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33236411

RESUMEN

Hospital malnutrition is a longstanding problem that continues to be underrecognized and undertreated. The aim of this narrative review is to summarize novel, solution-focused, recent research or commentary to update providers on the prevention of iatrogenic malnutrition as well as the detection and treatment of hospital malnutrition. A narrative review was completed using the top 11 clinically relevant nutrition journals. Of the 13,850 articles and editorials published in these journals between 2013 and 2019, 511 were related to hospital malnutrition. A duplicate review was used to select (n = 108) and extract key findings from articles and editorials. Key criteria for selection were population of interest (adult hospital patients, no specific diagnostic group), solution-focused, and novel perspectives. Articles were categorized (6 classified in >1 category) as Screening and Assessment (n = 17), Standard (n = 25), Advanced (n = 12) and Specialized Nutrition Care (n = 8), Transitions (n = 15), Multicomponent (n = 21), Education and Empowerment (n = 9), Economic Impact (n = 3), and Guidelines (n = 4) for summarizing. Research advances in screening implementation, standard nutrition care, transitions, and multicomponent interventions provide new strategies to consider for malnutrition prevention (iatrogenic), detection, and care. However, several areas requiring further research were identified. Specifically, larger and more rigorous studies that examine health outcomes and economic analyses are urgently needed.


Asunto(s)
Desnutrición , Terapia Nutricional , Publicaciones Periódicas como Asunto , Hospitales , Humanos , Desnutrición/diagnóstico , Desnutrición/prevención & control , Estado Nutricional
5.
JPEN J Parenter Enteral Nutr ; 41(6): 1072-1074, 2017 08.
Artículo en Inglés | MEDLINE | ID: mdl-26297019

RESUMEN

We report the use of ethanol lock therapy to dramatically reduce the incidence of catheter-related bloodstream infections (CRBSIs) in a long-term adult home parenteral nutrition (HPN) patient. This case study demonstrates the efficacy of ethanol lock therapy in eliminating CRBSIs when other treatments have been unsuccessful. We suggest that ethanol lock therapy has an important role in decreasing CRBSI in HPN patients with recurrent CRBSIs.


Asunto(s)
Bacteriemia/prevención & control , Infecciones Relacionadas con Catéteres/prevención & control , Nutrición Parenteral en el Domicilio/efectos adversos , Antibacterianos/uso terapéutico , Catéteres de Permanencia/efectos adversos , Catéteres de Permanencia/microbiología , Etanol/uso terapéutico , Femenino , Humanos , Incidencia , Persona de Mediana Edad
6.
Br J Nutr ; 114(10): 1612-22, 2015 Nov 28.
Artículo en Inglés | MEDLINE | ID: mdl-26369948

RESUMEN

This prospective cohort study was conducted in eighteen Canadian hospitals with the aim of examining factors associated with nutritional decline in medical and surgical patients. Nutritional decline was defined based on subjective global assessment (SGA) performed at admission and discharge. Data were collected on demographics, medical information, food intake and patients' satisfaction with nutrition care and meals during hospitalisation; 424 long-stay (≥7 d) patients were included; 38% of them had surgery; 51% were malnourished at admission (SGA B or C); 37% had in-hospital changes in SGA; 19·6% deteriorated (14·6% from SGA A to B/C and 5% from SGA B to C); 17·4% improved (10·6% from SGA B to A, 6·8% from SGA C to B/A); and 63·0 % patients were stable (34·4% were SGA A, 21·3% SGA B, 7·3% SGA C). One SGA C patient had weight loss ≥5%, likely due to fluid loss and was designated as stable. A subset of 364 patients with admission SGA A and B was included in the multiple logistic regression models to determine factors associated with nutritional decline. After controlling for SGA at admission and the presence of a surgical procedure, lower admission BMI, cancer, two or more diagnostic categories, new in-hospital infection, reduced food intake, dissatisfaction with food quality and illness affecting food intake were factors significantly associated with nutritional decline in medical patients. For surgical patients, only male sex was associated with nutritional decline. Factors associated with nutritional decline are different in medical and surgical patients. Identifying these factors may assist nutritional care.


Asunto(s)
Hospitalización , Desnutrición/epidemiología , Estado Nutricional , Anciano , Canadá/epidemiología , Estudios de Cohortes , Ingestión de Alimentos , Femenino , Humanos , Tiempo de Internación , Masculino , Comidas , Evaluación Nutricional , Terapia Nutricional , Satisfacción del Paciente , Cuidados Posoperatorios , Estudios Prospectivos , Factores Sexuales , Pérdida de Peso
8.
JPEN J Parenter Enteral Nutr ; 35(4): 499-504, 2011 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-21540352

RESUMEN

BACKGROUND: In addition to its role in bone metabolism, vitamin D has important immunomodulatory and antineoplastic effects. Patients on home parenteral nutrition (HPN) receive most of their vitamin D from intravenous (IV) supplementation. Vitamin D deficiency is common in the general population, and the adequacy of vitamin D supplementation in HPN patients is unclear. The purpose of this study is to determine the vitamin D status of patients on HPN. METHODS: Consecutive patients seen in a regional home nutrition program had their oral and IV vitamin D intakes determined. Plasma 25-hydroxyvitamin D levels were measured in all patients. Intake of calcium, magnesium, and phosphate were also determined. RESULTS: The mean 25-hydroxyvitamin D level in 22 patients receiving HPN for a mean of 33.5 months (range, 1-177) was 42 nmol/L. Vitamin D deficiency was present in 15 (68%) patients and vitamin D insufficiency in 6 (27%) patients. The mean dietary vitamin D intake was 79.5 IU per day, while the mean IV supplementation was 166 IU per day. CONCLUSIONS: In this study of a regional Canadian HPN program, there was a high prevalence of vitamin D deficiency/insufficiency affecting virtually all patients. All patients receiving HPN should be supplemented with vitamin D and have their 25-hydroxyvitamin D levels monitored. Further studies are required to determine optimal methods and dosing of vitamin D replacement using oral supplements or ultraviolet light therapy.


Asunto(s)
Nutrición Parenteral en el Domicilio/efectos adversos , Deficiencia de Vitamina D/sangre , Deficiencia de Vitamina D/epidemiología , Adulto , Anciano , Anciano de 80 o más Años , Calcio de la Dieta/administración & dosificación , Canadá , Suplementos Dietéticos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Nutrición Parenteral en el Domicilio/métodos , Prevalencia , Vitamina D/análogos & derivados , Vitamina D/sangre , Vitaminas/sangre , Adulto Joven
9.
Nutrition ; 22(11-12): 1210-3, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-17095407

RESUMEN

OBJECTIVES: Patients with Crohn's disease who have terminal ileal resections are at risk for vitamin B12 malabsorption. Our aim was to determine whether the length of terminal ileum resected correlated with an abnormal Schilling test result. METHODS: Patients with a history of ileal resection had the length of small bowel removed determined by review of their pathology report. Patients who had a Schilling test within 3 mo of surgery or who had a documented normal terminal ileum at the time of the Schilling test were included in the study. RESULTS: Fifty-six patients were included in the study. Patients who had <20 cm of terminal ileum resected (n = 14) did not develop abnormal Schilling test results; 52% of the remainder (n = 42) had abnormal Schilling test results and there was no clear correlation between resection length and abnormal Schilling test result. CONCLUSIONS: Patients with Crohn's disease and terminal ileal resections <20 cm are not at risk of developing vitamin B12 deficiency. For patients with resections of 20-60 cm, options include doing a Schilling test and treating those with abnormal results, empirically treating patients on the presumption that they are at high risk of developing deficiency, or monitoring for biochemical evidence of deficiency. Further studies are needed to determine whether oral supplementation is effective in these patients.


Asunto(s)
Enfermedad de Crohn/metabolismo , Enfermedad de Crohn/cirugía , Íleon/metabolismo , Íleon/cirugía , Deficiencia de Vitamina B 12/etiología , Vitamina B 12/farmacocinética , Adulto , Anastomosis Quirúrgica , Femenino , Humanos , Absorción Intestinal , Síndromes de Malabsorción/epidemiología , Síndromes de Malabsorción/etiología , Masculino , Factores de Riesgo , Deficiencia de Vitamina B 12/epidemiología
10.
JPEN J Parenter Enteral Nutr ; 28(1): 30-3, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-14763791

RESUMEN

BACKGROUND: Vitamin K is not a component of the multivitamin preparation added to parenteral nutrition (PN) solutions, and hospitalized patients receiving parenteral nutrition support are at risk of developing vitamin K deficiency. METHODS: In this study, 84 consecutive patients receiving PN were followed up prospectively to determine the incidence of a raised international normalized ratio (INR). All patients received lipid in their PN, which contains approximately 30 microg of vitamin K/100 mL. RESULTS: Patients were followed up for the course of PN or up to 4 weeks if they needed longer total parenteral nutrition. A raised INR compared with baseline developed in 3.6% of patients. All elevations were mild, and no patients developed clinical bleeding. CONCLUSIONS: It may be unnecessary to routinely supplement patients with vitamin K if they are receiving a lipid emulsion containing significant amounts of vitamin K. For patients receiving warfarin therapy, it will be important for nutrition support services to be aware of the vitamin K content of the lipid emulsion they are using as patients receiving a multivitamin preparation containing vitamin K and lipid emulsion may receive increased amounts of vitamin K, which could lead to warfarin resistance.


Asunto(s)
Trastornos de la Coagulación Sanguínea/epidemiología , Emulsiones Grasas Intravenosas , Hospitalización , Nutrición Parenteral , Anciano , Trastornos de la Coagulación Sanguínea/etiología , Trastornos de la Coagulación Sanguínea/prevención & control , Femenino , Humanos , Masculino , Persona de Mediana Edad , Nutrición Parenteral/efectos adversos , Estudios Prospectivos , Vitamina K/administración & dosificación , Deficiencia de Vitamina K/epidemiología
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