[PRACTICE OF MANAGEMENT OF PATIENTS WITH INFECTIOUS ENDOCARDITIS IN CONDITIONS OF LOW FREQUENCY OF ETIOLOGICALLY SIGNIFICANT PATHOGENS IN THE RUSSIAN FEDERATION].

The article presents the results of a multicenter study of the etiology, antibiotic sensitivity and pharmacoepidemiology of infective endocarditis in the Russian Federation. The purpose of this study is to analyze the current practice of management of patients with infective endocarditis in conditions of low frequency of etiologically significant pathogens in the Russian Federation. The study included patients of both sexes of all age groups with definite and probable infective endocarditis. 406 cases of infectious endocarditis (240 in retrospect and 166 in the prospective part) were analyzed. Etiologically significant pathogen was isolated in 144 cases (35.5%). The structure of pathogens was dominated by gram (+) cocci (90.3%), most often - Staphylococcus aureus (46.5% of all isolated pathogens). Aminoglycosides (22.8%), parenteral cephalosporins of the III generation (22.1%) and glycopeptides (14.5%) were most frequently used in the course of starting antimicrobial therapy. When changing the mode of antimicrobial therapy, glycopeptides (18.6%), aminoglycosides (15.3%), fluoroquinolones (11.2%) and parenteral cephalosporins of generation III (9.5%) were most often prescribed.

[The pharmacological correction of the activity of lipid peroxidation processes in the dynamics of craniocerebral trauma]. / Farmakologicheskaia korrektsiia aktivnosti protsessov perekisnogo okisleniia lipidov v dinamike cherepno-mozgovoi travmy.

Rat experiments have shown that free radical oxidation processes are activated in the cerebral mitochondrial fraction in the dynamics of craniocerebral injury, which appears as accumulation of malonic dialdehyde and disturbed functional interaction of antiradical protection enzymes. These changes are most marked 24 hours after injury. Some GABA-positive drugs and opioid receptor agonists prevent lipid peroxidation activation. The highest efficiency is displayed by piracetam (1 g/kg) and the synthetic enkephalin analogue DSLET (0.1 mg/kg).

[The therapeutic efficacy of ribamidil and virazole in experimental Lassa fever in monkeys]. / Terapevticheskaia éffektivnost' ribamidila i virazola pri éksperimental'noi likhoradke Lassa u obez'ian.

The therapeutic efficacy of ribamydil and virasol was evaluated in experimental Lassa fever in monkeys which received these drugs at various intervals after the onset of the clinical illness. Ribamydil or virasol administered in the first day of fever protected from death 60% to 66% of the infected animals, but when the drugs were given 2 days after the onset of fever the number of survivors declined to 0.20%. When the treatment was started 4 days after the onset of fever none of the drugs prevented deaths of Lassa virus-infected baboons.

[Comparative evaluation of the antiviral efficacy of virazole and ribamidil in experimental Lassa fever in monkeys]. / Sravnitel'naia otsenka protivovirusnoi éffektivnosti virazola i ribamidila pri éksperimental'noi likhoradke Lassa u obez'ian.

Lassa virus administered to monkeys aerogenically induced in these laboratory animals a fatal disease modelling the severe course of human Lassa fever. It was demonstrated experimentally that ribamydil, a Soviet analogue of virasol, as well as foreign commercial virasol was therapeutically effective in experimental Lassa fever in aerogenically infected monkeys.