Can erythrocytes behavior in microcirculation help the understanding the physiopathology and improve prevention and treatment for covid-19?

Low plasma estrogens, vitamin D deficiency, obesity, diabetes, cardiovascular diseases, thromboembolism, and impaired microcirculation are linked to the severity of covid-19. Studies have suggested that these comorbidities also are related to erythrocyte factors linked to increased blood viscosity in microcirculation such as erythrocyte aggregation and erythrocyte deformability. Increased blood viscosity in microcirculation can lead to a decrease in oxygenation and nutrition of tissues. Therefore erythrocyte aggregation and erythrocyte deformability may be involved in covid-19 severity, leading to tissue hypoxia and a decrease of drug concentration in affected organs. If this relationship is demonstrated, erythrocytes factors can be used to monitor treatments for improve microcirculatory fluidity that may decrease covid-19 severity. Lifestyle improvement and treatments such as vitamin D and estrogens supplementation are some possible approaches to improve microcirculation and covid-19 prevention and treatment.

Inducao do trabalho de parto por estimulacao eletrica sobre pontos de acupuntura: utilizacao da estimulacao eletrica transcutanea (TENS) e de / Induction of labor by electro-stimulation on acupuncture points using transcutaneous eletric nerve stimulation (TENS) and eletrodo sylver point (SSP)

A inducao do trabalho de parto atraves da eletro-estimulacao nos pontos de acupuntura tem-se mostrado como um metodo seguro e eficaz. Foram estudadas 20 gestantes, com indicacao de parto terapeutico, com a eletro-estimulacao, sem uso de agulhas, utilizando-se eletrodos tipo TENS sobre pontos auxiliares e eletrodos tipo SSP em pontos principais. Todas as pacientes apresentavam indice de Bishop modificado maior ou igual a cinco e contracoes uterinas ausentes. O estudo tocometrico foi realizado atraves da avaliacao clinica e do registro tocografico externo...