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1.
J Ethnopharmacol ; 279: 114369, 2021 Oct 28.
Artículo en Inglés | MEDLINE | ID: mdl-34186100

RESUMEN

ETHNOPHARMACOLOGICAL RELEVANCE: Several medicinal plants are used in Mayan Traditional Medicine to treat skin, urinary, respiratory, and gastrointestinal infectious diseases. However, scientific studies that have supported the bioactivity of these Mayan medicinal plants are limited. AIM OF THE STUDY: To assess the in-vitro anti-Staphylococcus aureus growth and biofilm-formation activities of 15 Mayan medicinal plants that were selected based on their traditional uses for the treatment of infectious diseases. MATERIALS AND METHODS: Mayan medicinal plants used traditionally to treat infectious diseases were preselected. For each part of the plants, four extracts were prepared with different solvents (water, n-hexane, ethyl acetate, and methanol). These were tested against two reference strains: a Methicillin-susceptible and -resistant S. aureus, and two clinical isolates, including a susceptible and multidrug-resistant S. aureus using a Resazurin Microtiter Assay. In addition, the plant extracts were evaluated in biofilm-formation inhibition on S. aureus by means of the Crystal Violet method. RESULTS: A total of 120 extracts from 15 Mayan medicinal plant species belonging to 12 different families were selected according their ethnopharmacological uses to treat infectious diseases. Among the selected plant species, 26 extracts obtained from eight medicinal Mayan plants exhibited significant anti-S. aureus against the four strains tested. The most active extracts were the Aq (aqueous) leaf extract of Krugiodendron ferreum (Minimal Inhibitory Concentration [MIC] = 125-250 µg/mL), the MeOH bark extracts of Matayba oppositifolia, Clusia flava, Gymnopodium floribundum, the MeOH leaf extract of Spondias purpurea with MIC values of 250 µg/mL, and the MeOH leaf and Aq bark extracts of K. ferreum (MIC = 250-500 µg/mL). Among the active extracts, 12 exhibited a bactericidal effect on S. aureus strains (Minimal Bactericidal Concentration [MBC] = 250-1000 µg/mL). Forty extracts from 13 plants have an effect on the anti-formation of biofilm, the most active were the MeOH leaf extract of M. oppositifolia (one-half Inhibitory Concentration [IC50] = 10.4 µg/mL) and the MeOH (IC50 = 17.7 µg/mL) and Hex (18.2 µg/mL) leaf extracts from S. purpurea. CONCLUSION: Aqueous and organic extracts from Mayan medicinal plants showed bactericidal and anti-biofilm activities even against drug-resistant S. aureus strains. The present study supports the traditional usage of some plants employed in Mayan medicine for illnesses such as skin, gastrointestinal, and urinary infections and suggest that these plants could be a good source of antibacterial phytochemicals.


Asunto(s)
Antibacterianos/farmacología , Extractos Vegetales/farmacología , Plantas Medicinales/química , Staphylococcus aureus/efectos de los fármacos , Antibacterianos/aislamiento & purificación , Biopelículas/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Medicina Tradicional , Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos , México , Pruebas de Sensibilidad Microbiana , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones Estafilocócicas/microbiología
2.
Drug Dev Res ; 78(2): 91-97, 2017 03.
Artículo en Inglés | MEDLINE | ID: mdl-28176363

RESUMEN

Preclinical Research The purpose of this work was to assess the antinociceptive and antihyperalgesic properties of an herbal preparation, composed of four vegetal species: Pouteria campechiana (P. campechiana), Chrysophyllum cainito (C. cainito), Citrus limonum (C. limonum), and Annona muricata (A. muricata), that is commonly used in combination (PCCA) in traditional Mayan medicine for the treatment of diabetes and pain. An ethanolic extract of PCCA was prepared at a ratio of 1:1:1:1 for each plant. The systemic antinociceptive effect of PCCA extract (50-600 mg/kg, p.o.) was dose-dependent in the rat formalin (1%) producing 66% antinociceptive response at 400 mg/kg, p.o. A concentration-dependent antinociceptive effect of the PCCA extract (20-160 mg/paw) was also demonstrated in the rat capsaicin (0.2%) test. The PCCA extract (100-400 mg/kg, p.o.) had antihyperalgesic effects in alloxan diabetic rats. These findings demonstrate the antinociceptive and antihyperalgesic effects of PCCA and supports the use of the plant extracts in Mayan folk medicine. Drug Dev Res 78 : 91-97, 2017. © 2017 Wiley Periodicals, Inc.


Asunto(s)
Analgésicos/administración & dosificación , Diabetes Mellitus Experimental/tratamiento farmacológico , Hipoglucemiantes/administración & dosificación , Dolor/tratamiento farmacológico , Extractos Vegetales/administración & dosificación , Aloxano/efectos adversos , Analgésicos/uso terapéutico , Animales , Annona/química , Capsaicina/efectos adversos , Citrus/química , Diabetes Mellitus Experimental/inducido químicamente , Diabetes Mellitus Experimental/complicaciones , Relación Dosis-Respuesta a Droga , Hipoglucemiantes/uso terapéutico , Masculino , Dolor/inducido químicamente , Extractos Vegetales/uso terapéutico , Pouteria/química , Ratas
3.
Rev. bioméd. (México) ; 20(1): 1-4, 2009.
Artículo en Español | LILACS, MTYCI | ID: biblio-1179392

RESUMEN

Nos complace presentar en este número, el primero del Volumen 20, un artículo original que demuestra una actividad larvicida de plantas americanas contra Aedes aegypti (transmisor del dengue), lo que representa una herramienta alternativa de elevado impacto dentro de las medidas para el control y el manejo integrado de vectores.


Asunto(s)
Plantas Medicinales , Dengue , Control de Plagas , Medicina Tradicional
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