Asunto(s)
Cistitis Intersticial/terapia , Encefalinas/genética , Terapia Genética/métodos , Manejo del Dolor , Precursores de Proteínas/genética , Enfermedades de la Vejiga Urinaria/terapia , Vías Aferentes/efectos de los fármacos , Vías Aferentes/fisiología , Animales , Capsaicina , Encefalinas/metabolismo , Femenino , Vectores Genéticos/uso terapéutico , Herpesviridae , Dolor/inducido químicamente , Precursores de Proteínas/metabolismo , Ratas , Vejiga Urinaria/efectos de los fármacos , Vejiga Urinaria/inervación , Enfermedades de la Vejiga Urinaria/inducido químicamenteAsunto(s)
Capsaicina/administración & dosificación , Vejiga Urinaria Neurogénica/tratamiento farmacológico , Administración Intravesical , Animales , Capsaicina/farmacología , Capsaicina/uso terapéutico , Estado de Descerebración/fisiopatología , Humanos , Neuronas Aferentes/efectos de los fármacos , Nervios Periféricos/efectos de los fármacos , Receptores de Droga/fisiología , Reflejo/efectos de los fármacos , Micción/fisiologíaRESUMEN
Hypothalamic contents of gonadotropin-releasing hormone (GnRH) in neonatally orchidectomized infant, juvenile, and adult monkeys were measured by a radioimmunoassay (RIA) and by an in vivo bioassay that utilized luteinizing hormone (LH) secretion in estrogen- and progesterone-treated ovariectomized rats. The results of the bioassay provided no evidence to suggest that hypothalamic GnRH content in juvenile monkeys (mean = 83 ng/hypothalamus; n = 3) was less than that in infants (mean = 54 ng/hypothalamus; n = 4) and adults (mean = 36 ng/hypothalamus; n = 3). A similar developmental pattern in hypothalamic GnRH content was also observed when the decapeptide was measured by RIA. In striking contrast to the maintenance of hypothalamic GnRH content throughout postnatal development, pituitary gonadotropin contents and serum gonadotropin concentrations were markedly reduced in juvenile monkeys.