Pharmacokinetic Study of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles HY-088 in Rats.

BACKGROUND AND OBJECTIVE: HY-088 injection is an ultrasmall superparamagnetic iron oxide nanoparticle (USPIOs) composed of iron oxide crystals coated with polyacrylic acid (PAA) on the surface. The purpose of this study was to investigate the pharmacokinetics, tissue distribution, and mass balance of HY-088 injection. METHODS: The pharmacokinetics of [55Fe]-HY-088 and [14C]-HY-088 were investigated in 48 SD rats by intravenous injection of 8.5 (low-dose group), 25.5 (medium-dose group), and 85 (high-dose group) mg/100 µCi/kg. Tissue distribution was studied by intravenous injection of 35 mg/100 µCi/kg in 48 SD rats, and its tissue distribution in vivo was obtained by ex vivo tissue assay. At the same time, [14C]-HY-088 was injected intravenously at a dose of 25.5 mg/100 µCi/kg into 16 SD rats, and its tissue distribution in vivo was studied by quantitative whole-body autoradiography. [14C]-HY-088 and [55Fe]-HY-088 were injected intravenously into 24 SD rats at a dose of 35 mg/100 µCi/kg, and their metabolism was observed. RESULTS: In the pharmacokinetic study, [55Fe]-HY-088 reached the maximum observed concentration (Cmax) at 0.08 h in the low- and medium-dose groups of SD rats. [14C]-HY-088 reached Cmax at 0.08 h in the three groups of SD rats. The area under the concentration-time curve (AUC) of [55Fe]-HY-088 and [14C]-HY-088 increased with increasing dose. In the tissue distribution study, [55Fe]-HY-088 and [14C]-HY-088 were primarily distributed in the liver, spleen, and lymph nodes of both female and male rats. In the mass balance study conducted over 57 days, the radioactive content of 55Fe from [55Fe]-HY-088 was primarily found in the carcass, accounting for 86.42 ± 4.18% in females and 95.46 ± 6.42% in males. The radioactive recovery rates of [14C]-HY-088 in the urine of female and male rats were 52.99 ± 5.48% and 60.66 ± 2.23%, respectively. CONCLUSIONS: Following single intravenous administration of [55Fe]-HY-088 and [14C]-HY-088 in SD rats, rapid absorption was observed. Both [55Fe]-HY-088 and [14C]-HY-088 were primarily distributed in the liver, spleen, and lymph nodes. During metabolism, the radioactivity of [55Fe]-HY-088 is mainly present in the carcass, whereas the 14C-labeled [14C]-HY-088 shell PAA is eliminated from the body mainly through the urine.

Efficient removal of nitrogen and phosphorus in aqueous solutions using modified water treatment residuals-sodium alginate beads.

A high-performance sorbent, modified water treatment residuals-sodium alginate beads (WTR-SA beads), was prepared through a series of salt and combined thermal roasting composite modification between water treatment residuals and sodium alginate. The properties of modified WTR-SA beads composites were characterized by SEM-EDS, FT-IR, XRD, and BET. The adsorption performance of WTR-SA beads was investigated in removing nitrogen and phosphorus from wastewater. Compared to the unmodified WTR, the removal efficiency of nitrogen and phosphorus onto the modified WTR-SA beads was increased from 22.34 and 77.13% to 95.14 and 98.31%, respectively. The adsorption capacities of nitrogen and phosphorus onto the modified WTR-SA beads were reach a maximum of 2.52 mg/g and 6.45 mg/g, respectively. The adsorption behavior can be well described using a quasi-second-order kinetic model and Langmuir isotherm model. The thermodynamic properties of nitrogen adsorption indicated that the adsorption was spontaneous and exothermic. On the contrary, the adsorption process of phosphorus is an endothermic reaction. The adsorption of nitrogen by modified WTR-SA beads is mainly carried out through ion exchange and hydroxyl complexation, and ion exchange plays a major role in it. While, the adsorption of modified WTR-SA beads on phosphorus is affected by three actions: ligand exchange, chemical precipitation, and ion exchange, which ligand exchange is the main effect. Based on these results, it can be concluded that the modified WTR-SA beads are a high efficiency adsorbent for removing nitrogen and phosphorus from domestic and industrial wastewater.