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1.
Nature ; 599(7884): 256-261, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-34707286

RESUMEN

The identity of the earliest inhabitants of Xinjiang, in the heart of Inner Asia, and the languages that they spoke have long been debated and remain contentious1. Here we present genomic data from 5 individuals dating to around 3000-2800 BC from the Dzungarian Basin and 13 individuals dating to around 2100-1700 BC from the Tarim Basin, representing the earliest yet discovered human remains from North and South Xinjiang, respectively. We find that the Early Bronze Age Dzungarian individuals exhibit a predominantly Afanasievo ancestry with an additional local contribution, and the Early-Middle Bronze Age Tarim individuals contain only a local ancestry. The Tarim individuals from the site of Xiaohe further exhibit strong evidence of milk proteins in their dental calculus, indicating a reliance on dairy pastoralism at the site since its founding. Our results do not support previous hypotheses for the origin of the Tarim mummies, who were argued to be Proto-Tocharian-speaking pastoralists descended from the Afanasievo1,2 or to have originated among the Bactria-Margiana Archaeological Complex3 or Inner Asian Mountain Corridor cultures4. Instead, although Tocharian may have been plausibly introduced to the Dzungarian Basin by Afanasievo migrants during the Early Bronze Age, we find that the earliest Tarim Basin cultures appear to have arisen from a genetically isolated local population that adopted neighbouring pastoralist and agriculturalist practices, which allowed them to settle and thrive along the shifting riverine oases of the Taklamakan Desert.


Asunto(s)
Arqueología , Genoma Humano/genética , Genómica , Migración Humana/historia , Momias/historia , Filogenia , Agricultura/historia , Animales , Bovinos , China , Características Culturales , Cálculos Dentales/química , Clima Desértico , Dieta/historia , Europa (Continente) , Femenino , Cabras , Pradera , Historia Antigua , Humanos , Masculino , Proteínas de la Leche/análisis , Filogeografía , Análisis de Componente Principal , Proteoma/análisis , Proteómica , Ovinos , Secuenciación Completa del Genoma
2.
Science ; 373(6562): 1479-1484, 2021 Sep 24.
Artículo en Inglés | MEDLINE | ID: mdl-34554811

RESUMEN

Recent advancements in DNA sequencing technologies and laboratory preparation protocols have rapidly expanded the scope of ancient DNA research over the past decade, both temporally and geographically. Discoveries include interactions between archaic and modern humans as well as modern human population dynamics, including those coinciding with the Last Glacial Maximum and the settlement history of most world regions. This new type of data allows us to examine the deep past of human population dynamics and sharpen the current understanding of our present. The continued development in the ancient DNA field has transformed our understanding of human genetic history and will keep uncovering the further mysteries of our recent evolutionary past.


Asunto(s)
ADN Antiguo , Genoma Humano , Genómica , Dinámica Poblacional , África , Américas , Animales , Asia , Evolución Biológica , Europa (Continente) , Historia Antigua , Migración Humana , Humanos , Hombre de Neandertal/genética , Oceanía , Siberia
3.
Mol Biol Evol ; 38(11): 4908-4917, 2021 10 27.
Artículo en Inglés | MEDLINE | ID: mdl-34320653

RESUMEN

Although Uzbekistan and Central Asia are known for the well-studied Bronze Age civilization of the Bactria-Margiana Archaeological Complex (BMAC), the lesser-known Iron Age was also a dynamic period that resulted in increased interaction and admixture among different cultures from this region. To broaden our understanding of events that impacted the demography and population structure of this region, we generated 27 genome-wide single-nucleotide polymorphism capture data sets of Late Iron Age individuals around the Historical Kushan time period (∼2100-1500 BP) from three sites in South Uzbekistan. Overall, Bronze Age ancestry persists into the Iron Age in Uzbekistan, with no major replacements of populations with Steppe-related ancestry. However, these individuals suggest diverse ancestries related to Iranian farmers, Anatolian farmers, and Steppe herders, with a small amount of West European Hunter Gatherer, East Asian, and South Asian Hunter Gatherer ancestry as well. Genetic affinity toward the Late Bronze Age Steppe herders and a higher Steppe-related ancestry than that found in BMAC populations suggest an increased mobility and interaction of individuals from the Northern Steppe in a Southward direction. In addition, a decrease of Iranian and an increase of Anatolian farmer-like ancestry in Uzbekistan Iron Age individuals were observed compared with the BMAC populations from Uzbekistan. Thus, despite continuity from the Bronze Age, increased admixture played a major role in the shift from the Bronze to the Iron Age in southern Uzbekistan. This mixed ancestry is also observed in other parts of the Steppe and Central Asia, suggesting more widespread admixture among local populations.


Asunto(s)
Arqueología , Migración Humana , ADN Antiguo , Agricultores , Genoma Humano , Historia Antigua , Humanos , Irán , Uzbekistán
4.
Nature ; 592(7853): 253-257, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33828320

RESUMEN

Modern humans appeared in Europe by at least 45,000 years ago1-5, but the extent of their interactions with Neanderthals, who disappeared by about 40,000 years ago6, and their relationship to the broader expansion of modern humans outside Africa are poorly understood. Here we present genome-wide data from three individuals dated to between 45,930 and 42,580 years ago from Bacho Kiro Cave, Bulgaria1,2. They are the earliest Late Pleistocene modern humans known to have been recovered in Europe so far, and were found in association with an Initial Upper Palaeolithic artefact assemblage. Unlike two previously studied individuals of similar ages from Romania7 and Siberia8 who did not contribute detectably to later populations, these individuals are more closely related to present-day and ancient populations in East Asia and the Americas than to later west Eurasian populations. This indicates that they belonged to a modern human migration into Europe that was not previously known from the genetic record, and provides evidence that there was at least some continuity between the earliest modern humans in Europe and later people in Eurasia. Moreover, we find that all three individuals had Neanderthal ancestors a few generations back in their family history, confirming that the first European modern humans mixed with Neanderthals and suggesting that such mixing could have been common.


Asunto(s)
ADN Antiguo/análisis , Genoma Humano/genética , Hombre de Neandertal/genética , Alelos , Américas/etnología , Animales , Arqueología , Bulgaria/etnología , Cuevas , Asia Oriental/etnología , Femenino , Historia Antigua , Humanos , Masculino , Filogenia
5.
J Hum Genet ; 65(12): 1125-1128, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-32653893

RESUMEN

The genetic history of Southern East Asians is not well-known, especially prior to the Neolithic period. To address this, we successfully sequenced two complete mitochondrial genomes of 11,000-year-old human individuals from Southern China, thus generating the oldest ancient DNA sequences from this area. Integrating published mitochondrial genomes, we characterized M71d, a new subhaplogroup of haplogroup M71. Our results suggest a possible early migration between Southern China and mainland Southeast Asia by at least 22,000 BP.


Asunto(s)
Pueblo Asiatico/genética , ADN Antiguo/análisis , ADN Mitocondrial/genética , Genoma Mitocondrial/genética , Asia Sudoriental , China/epidemiología , ADN Mitocondrial/clasificación , Haplotipos/genética , Historia Antigua , Humanos
6.
Nature ; 570(7760): 182-188, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-31168093

RESUMEN

Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through analyses of 34 newly recovered ancient genomes that date to between 31,000 and 600 years ago. We document complex population dynamics during this period, including at least three major migration events: an initial peopling by a previously unknown Palaeolithic population of 'Ancient North Siberians' who are distantly related to early West Eurasian hunter-gatherers; the arrival of East Asian-related peoples, which gave rise to 'Ancient Palaeo-Siberians' who are closely related to contemporary communities from far-northeastern Siberia (such as the Koryaks), as well as Native Americans; and a Holocene migration of other East Asian-related peoples, who we name 'Neo-Siberians', and from whom many contemporary Siberians are descended. Each of these population expansions largely replaced the earlier inhabitants, and ultimately generated the mosaic genetic make-up of contemporary peoples who inhabit a vast area across northern Eurasia and the Americas.


Asunto(s)
Genoma Humano/genética , Migración Humana/historia , Asia/etnología , ADN Antiguo/análisis , Europa (Continente)/etnología , Pool de Genes , Haplotipos , Historia del Siglo XV , Historia Antigua , Historia Medieval , Humanos , Indígenas Norteamericanos , Masculino , Siberia/etnología
7.
Nature ; 538(7626): 510-513, 2016 Oct 27.
Artículo en Inglés | MEDLINE | ID: mdl-27698418

RESUMEN

The appearance of people associated with the Lapita culture in the South Pacific around 3,000 years ago marked the beginning of the last major human dispersal to unpopulated lands. However, the relationship of these pioneers to the long-established Papuan people of the New Guinea region is unclear. Here we present genome-wide ancient DNA data from three individuals from Vanuatu (about 3,100-2,700 years before present) and one from Tonga (about 2,700-2,300 years before present), and analyse them with data from 778 present-day East Asians and Oceanians. Today, indigenous people of the South Pacific harbour a mixture of ancestry from Papuans and a population of East Asian origin that no longer exists in unmixed form, but is a match to the ancient individuals. Most analyses have interpreted the minimum of twenty-five per cent Papuan ancestry in the region today as evidence that the first humans to reach Remote Oceania, including Polynesia, were derived from population mixtures near New Guinea, before their further expansion into Remote Oceania. However, our finding that the ancient individuals had little to no Papuan ancestry implies that later human population movements spread Papuan ancestry through the South Pacific after the first peopling of the islands.


Asunto(s)
Pueblo Asiatico/genética , Genoma Humano/genética , Genómica , Migración Humana/historia , Nativos de Hawái y Otras Islas del Pacífico/genética , Filogenia , Femenino , Genética de Población , Historia Antigua , Humanos , Masculino , Nueva Guinea/etnología , Polinesia/etnología , Tonga , Vanuatu
8.
Nature ; 538(7624): 201-206, 2016 Oct 13.
Artículo en Inglés | MEDLINE | ID: mdl-27654912

RESUMEN

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.


Asunto(s)
Variación Genética/genética , Genoma Humano/genética , Genómica , Tasa de Mutación , Filogenia , Grupos Raciales/genética , Animales , Australia , Población Negra/genética , Conjuntos de Datos como Asunto , Genética de Población , Historia Antigua , Migración Humana/historia , Humanos , Nativos de Hawái y Otras Islas del Pacífico/genética , Hombre de Neandertal/genética , Nueva Guinea , Análisis de Secuencia de ADN , Especificidad de la Especie , Factores de Tiempo
9.
Nature ; 536(7617): 419-24, 2016 08 25.
Artículo en Inglés | MEDLINE | ID: mdl-27459054

RESUMEN

We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 bc, from Natufian hunter-gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a 'Basal Eurasian' lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local hunter-gatherers. By the time of the Bronze Age, these two populations and Anatolian-related farmers had mixed with each other and with the hunter-gatherers of Europe to greatly reduce genetic differentiation. The impact of the Near Eastern farmers extended beyond the Near East: farmers related to those of Anatolia spread westward into Europe; farmers related to those of the Levant spread southward into East Africa; farmers related to those of Iran spread northward into the Eurasian steppe; and people related to both the early farmers of Iran and to the pastoralists of the Eurasian steppe spread eastward into South Asia.


Asunto(s)
Agricultura/historia , Genómica , Migración Humana/historia , Filogenia , Grupos Raciales/genética , África Oriental , Animales , Armenia , Asia , ADN/análisis , Europa (Continente) , Historia Antigua , Humanos , Hibridación Genética/genética , Irán , Israel , Jordania , Hombre de Neandertal/genética , Filogeografía , Turquía
10.
Nature ; 534(7606): 200-5, 2016 06 09.
Artículo en Inglés | MEDLINE | ID: mdl-27135931

RESUMEN

Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. Here we analyse genome-wide data from 51 Eurasians from ~45,000-7,000 years ago. Over this time, the proportion of Neanderthal DNA decreased from 3-6% to around 2%, consistent with natural selection against Neanderthal variants in modern humans. Whereas there is no evidence of the earliest modern humans in Europe contributing to the genetic composition of present-day Europeans, all individuals between ~37,000 and ~14,000 years ago descended from a single founder population which forms part of the ancestry of present-day Europeans. An ~35,000-year-old individual from northwest Europe represents an early branch of this founder population which was then displaced across a broad region, before reappearing in southwest Europe at the height of the last Ice Age ~19,000 years ago. During the major warming period after ~14,000 years ago, a genetic component related to present-day Near Easterners became widespread in Europe. These results document how population turnover and migration have been recurring themes of European prehistory.


Asunto(s)
Cubierta de Hielo , Población Blanca/genética , Población Blanca/historia , Animales , Evolución Biológica , ADN/análisis , ADN/genética , ADN/aislamiento & purificación , Europa (Continente) , Femenino , Efecto Fundador , Genética de Población , Historia Antigua , Migración Humana/historia , Humanos , Masculino , Medio Oriente , Hombre de Neandertal/genética , Filogenia , Dinámica Poblacional , Selección Genética , Análisis de Secuencia de ADN , Factores de Tiempo
11.
Nature ; 522(7555): 207-11, 2015 Jun 11.
Artículo en Inglés | MEDLINE | ID: mdl-25731166

RESUMEN

We generated genome-wide data from 69 Europeans who lived between 8,000-3,000 years ago by enriching ancient DNA libraries for a target set of almost 400,000 polymorphisms. Enrichment of these positions decreases the sequencing required for genome-wide ancient DNA analysis by a median of around 250-fold, allowing us to study an order of magnitude more individuals than previous studies and to obtain new insights about the past. We show that the populations of Western and Far Eastern Europe followed opposite trajectories between 8,000-5,000 years ago. At the beginning of the Neolithic period in Europe, ∼8,000-7,000 years ago, closely related groups of early farmers appeared in Germany, Hungary and Spain, different from indigenous hunter-gatherers, whereas Russia was inhabited by a distinctive population of hunter-gatherers with high affinity to a ∼24,000-year-old Siberian. By ∼6,000-5,000 years ago, farmers throughout much of Europe had more hunter-gatherer ancestry than their predecessors, but in Russia, the Yamnaya steppe herders of this time were descended not only from the preceding eastern European hunter-gatherers, but also from a population of Near Eastern ancestry. Western and Eastern Europe came into contact ∼4,500 years ago, as the Late Neolithic Corded Ware people from Germany traced ∼75% of their ancestry to the Yamnaya, documenting a massive migration into the heartland of Europe from its eastern periphery. This steppe ancestry persisted in all sampled central Europeans until at least ∼3,000 years ago, and is ubiquitous in present-day Europeans. These results provide support for a steppe origin of at least some of the Indo-European languages of Europe.


Asunto(s)
Evolución Cultural/historia , Pradera , Migración Humana/historia , Lenguaje/historia , Europa (Continente)/etnología , Genoma Humano/genética , Historia Antigua , Humanos , Masculino , Polimorfismo Genético/genética , Dinámica Poblacional , Federación de Rusia
12.
Nature ; 513(7518): 409-13, 2014 Sep 18.
Artículo en Inglés | MEDLINE | ID: mdl-25230663

RESUMEN

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.


Asunto(s)
Genoma Humano/genética , Población Blanca/clasificación , Población Blanca/genética , Agricultura/historia , Asia/etnología , Europa (Continente) , Historia Antigua , Humanos , Dinámica Poblacional , Análisis de Componente Principal , Recursos Humanos
13.
Proc Natl Acad Sci U S A ; 110(6): 2223-7, 2013 Feb 05.
Artículo en Inglés | MEDLINE | ID: mdl-23341637

RESUMEN

Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.


Asunto(s)
ADN Mitocondrial/genética , Hominidae/genética , Animales , Pueblo Asiatico/genética , Pueblo Asiatico/historia , Secuencia de Bases , China , Cromosomas Humanos Par 21/genética , ADN Mitocondrial/historia , ADN Mitocondrial/aislamiento & purificación , Fósiles , Biblioteca de Genes , Genética de Población , Historia Antigua , Humanos , Datos de Secuencia Molecular , Filogenia , Filogeografía , Análisis de Secuencia de ADN , Homología de Secuencia de Ácido Nucleico
14.
PLoS One ; 7(3): e32473, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22427842

RESUMEN

The Neolithic transition from hunting and gathering to farming and cattle breeding marks one of the most drastic cultural changes in European prehistory. Short stretches of ancient mitochondrial DNA (mtDNA) from skeletons of pre-Neolithic hunter-gatherers as well as early Neolithic farmers support the demic diffusion model where a migration of early farmers from the Near East and a replacement of pre-Neolithic hunter-gatherers are largely responsible for cultural innovation and changes in subsistence strategies during the Neolithic revolution in Europe. In order to test if a signal of population expansion is still present in modern European mitochondrial DNA, we analyzed a comprehensive dataset of 1,151 complete mtDNAs from present-day Europeans. Relying upon ancient DNA data from previous investigations, we identified mtDNA haplogroups that are typical for early farmers and hunter-gatherers, namely H and U respectively. Bayesian skyline coalescence estimates were then used on subsets of complete mtDNAs from modern populations to look for signals of past population expansions. Our analyses revealed a population expansion between 15,000 and 10,000 years before present (YBP) in mtDNAs typical for hunters and gatherers, with a decline between 10,000 and 5,000 YBP. These corresponded to an analogous population increase approximately 9,000 YBP for mtDNAs typical of early farmers. The observed changes over time suggest that the spread of agriculture in Europe involved the expansion of farming populations into Europe followed by the eventual assimilation of resident hunter-gatherers. Our data show that contemporary mtDNA datasets can be used to study ancient population history if only limited ancient genetic data is available.


Asunto(s)
Agricultura/historia , Evolución Cultural , ADN Mitocondrial/genética , Demografía , Emigración e Inmigración/historia , Filogenia , Dinámica Poblacional , Secuencia de Bases , Teorema de Bayes , Biología Computacional , Europa (Continente) , Evolución Molecular , Haplotipos/genética , Historia Antigua , Humanos , Modelos Genéticos , Datos de Secuencia Molecular , Análisis de Secuencia de ADN
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