RESUMEN
Suppression of bone marrow function is one of the most common adverse effects of chemotherapy for gastrointestinal cancer. In 3 patients with gastrointestinal cancer who underwent chemotherapy, Ninjin' yoeito(NYT)was found to be effective in preventing this adverse reaction. Patient 1, a 76-year-old woman with rectal carcinoma(pT3N1bM0, pStage â ¢b), underwent anterior rectal resection. Although chemotherapy(mFOLFOX6)was performed 6 weeks after the operation, the leukocyte and erythrocyte counts were decreased. NYT administration from day 9 of mFOLFOX6 chemotherapy resulted in the maintenance of bone marrow function and allowed continuation of chemotherapy. Patient 2 was a 65-year-old woman who underwent right hemi-colectomy for ascending colon cancer(pT3N0M0, pStage â ¡). A partial hepatectomy was performed for the second S8 liver metastasis, and NYT was administered at the time of introduction of mFOLFOX6. In patient 3, an 83-year-old woman who underwent total gastrectomy for gastric cancer(pT4a[SE]N3aM0, pStage â ¢b), NYT was administered at the same time as the transition to second-line treatment with paclitaxel plus ramucirumab. In all cases, chemotherapy was continued without drug suspension or dose reduction after NYT administration. Thus, NYT may be effective in aiding the continuation of chemotherapy.
Asunto(s)
Panax , Neoplasias Gástricas , Anciano , Anciano de 80 o más Años , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Médula Ósea/patología , Femenino , Hepatectomía , Humanos , Neoplasias Gástricas/cirugíaRESUMEN
A 69-year-old female who had undergone esophagectomy for esophageal cancer was given adjuvant chemotherapy (5-FU 750 mg/body x 5 day, cisplatinum (CDDP) 100 mg/body x 1 day). An electrolytic disorder was found on day 2, and her consciousness became unclear on 5 day (respective Na, K and Cl values of 113, 2.2 and 67 mEq/L in blood). It took 59 days for infusion therapy to control electrolyte for loss in urine. As the b2-microglobulin level was high in urine and the ADH level in blood was normal, cisplatinum nephrotoxicity was thought to make this accident. Electrolytes should be checked carefully for disorder during chemotherapy.