RESUMEN
Liriodenine (), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (), cis-[PtCl2(L)(DMSO)] (), and cis-[RuCl2(L)(DMSO)2].1.5H2O (), the crystal structures of , and were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, 1H and 13C NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of and complexes against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free , suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of and its complexes to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.
Asunto(s)
Antineoplásicos/farmacología , Aporfinas/farmacología , ADN/metabolismo , Medicina Tradicional China , Compuestos de Platino/química , Compuestos de Rutenio/química , Zanthoxylum/química , Antineoplásicos/química , Antineoplásicos/aislamiento & purificación , Aporfinas/química , Aporfinas/aislamiento & purificación , Línea Celular Tumoral , Dicroismo Circular , Cristalografía por Rayos X , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Espectroscopía de Resonancia Magnética , Estructura Molecular , Raíces de Plantas/química , Tallos de la Planta/química , Compuestos de Platino/farmacología , Compuestos de Rutenio/farmacologíaRESUMEN
Three new norditerpenoid alkaloids, nordhagenine A (1), nordhagenine B (2), and nordhagenine C (3), along with a known alkaloid, lycoctonine, were isolated from the aerial parts of Delphinium nordhagenii. The structures of the new compounds 1 and 2 were also deduced on the basis of single-crystal X-ray diffraction studies.
Asunto(s)
Alcaloides/aislamiento & purificación , Delphinium/química , Diterpenos/aislamiento & purificación , Plantas Medicinales/química , Aconitina/análogos & derivados , Aconitina/química , Aconitina/aislamiento & purificación , Alcaloides/química , Cristalografía por Rayos X , Diterpenos/química , Conformación Molecular , Estructura Molecular , PakistánRESUMEN
The title compounds, 2C(30)H(46)O(8).CH(3)OH.H(2)O, (I), and C(32)H(48)O(9), (II), respectively, are cardenolide glycosides which were isolated from the seeds of Cerbera odollam. There are two crystallographically independent cardenolide molecules in (I), together with one methanol and one water solvate molecule. In both (I) and (II), the steroid nuclei are in cis/trans/cis configurations, with the cyclopentane rings showing conformational flexibility, viz. an envelope conformation in (I) and a twisted conformation in (II). In both compounds, the lactone ring is nearly orthogonal to the cyclopentane ring. The packing of (I) is composed of molecular layers stabilized by five O-H...O hydrogen bonds. In the packing of (II), the molecules are packed into columns by one O-H...O hydrogen bond, and are further interconnected into a three-dimensional network by one O-H...O and three C-H...O interactions.