RESUMEN
Aerial and underground parts of Galanthus nivalis subsp. cilicicus, a wild-growing species in Turkey, were collected during two different vegetation periods in flowering and fruiting seasons. Herba and bulbus Galanthi were prepared from each specimen. With the aim of collecting data for prospective monographs on this drug, contents of humidity, ash, sulphated ash and total alkaloids were determined according to DAB 10. The specimens were also analyzed quantitatively for two of the principal alkaloids of the genus, galanthamine and lycorine, by using a method based on spectrophotometry complemented with TLC. LC50 values were determined for the ethanolic and alkaloidal extracts of each of the specimens using brine shrimp lethality bioassay.
Asunto(s)
Alcaloides/farmacología , Galanthus/química , Extractos Vegetales/farmacología , Alcaloides/química , Animales , Artemia/efectos de los fármacos , Extractos Vegetales/químicaRESUMEN
A novel prenylated arylnaphthalene lignan, 7-O-(3-methyl-2-butenyl)isodaurinol, was isolated from Haplophyllum myrtifolium and identified on the basis of detailed spectral analyses, including 2D-NMR spectrometry. The known furoquinoline alkaloids, dictamnine, robustine, gamma-fagarine and skimmianine, the aryltetralin lignan (-)-1beta-polygamain and the flavone chrysosplenetin were isolated from the same source.
Asunto(s)
Lignanos/química , Naftalenos/química , Fitoterapia , Extractos Vegetales/química , Rutaceae , Humanos , Espectroscopía de Resonancia Magnética , Componentes Aéreos de las Plantas , Prenilación de ProteínaRESUMEN
Roemeria hybrida yielded two novel proaporphine-tryptamine N-oxides, (-)-roehybridine alpha-N-oxide (1) and (-)-roehybramine beta-N-oxide (2). NMR data allowed a facile assignment of these proaporphine-tryptamine dimers into different stereochemical subgroups.
Asunto(s)
Alcaloides/química , Aporfinas , Isoquinolinas , Papaveraceae , Fitoterapia , Extractos Vegetales/química , Triptaminas/química , Humanos , Espectroscopía de Resonancia Magnética , Estructuras de las PlantasRESUMEN
Three new tazettine-type alkaloids were isolated from two different GALANTHUS species of Turkish origin. (+)-Isotazettinol and (+)-3- O-demethylmacronine are obtained from G. GRACILIS, while (+)-3- O-demethyl-3-epimacronine is found in G. PLICATUS subsp. BYZANTINUS. The known base, trispheridine, is reported for the first time in GALANTHUS genus.
RESUMEN
A novel compound, salutaridine N-oxide ( 1) has been isolated from PAPAVER BRACTEATUM Lindl (Papaveraceae) in which the major alkaloids were salutaridine and thebaine. Semisynthetic 1 was prepared for structure confirmation. Other components of the alkaloidal fraction were isothebaine, oripavine, neopine, and thebaine N-oxide.