[The anti-ischemic effects of 3-hydroxypyridine derivatives in cerebrovascular pathology]. / Protivoishemicheskie éffekty proizvodnykh 3-oksipiridina pri tserebrovaskuliarnoi patologii.

The effect of the antioxidant mexidol and two new derivatives of 3-oxypyridine, namely LBK-10 and LBK-39 on the circulation of blood and metabolism of the brain in the postischemic period was studied in acute experiments on narcotized cats under conditions of autohemoperfusion of the cerebral vessels with a stable volume of blood. Therapeutic injection of mexidol and LBK in a dose of 20 mg/kg inhibited the development of the no-flow phenomenon and restored the ischemia damaged metabolism in the brain tissues. LBK-10 reduced the lactate content in the blood flowing from the brain and contributed to constriction of the cerebral vessels.

[The action of emoxipin, lithium oxybutyrate and pikamilon on the blood circulation of the ischemic brain]. / Izuchenie deistviia émoksipina, litiia oksibutirata i pikamilona na krovoobrashchenie ishemizirovannogo mozga.

Acute experiments were conducted on rats under nembutal anesthesia to compare the efficacy of emoxipin with that of lithium oxybutyrate and picamilon in the postischemic period after preventive and therapeutic injections in various doses. Emoxipin proved to be most effective in prevention of postischemic non-restoration of the flow of blood in the brain and in preservation of the autoregulation responses of the cerebral vessels. The possible mechanisms of the effect of the drug are discussed.

[The effect of 3-hydroxypyridine derivatives on postischemic disorders in the autoregulatory reactions of the cerebral vessels]. / Vliianie proizvodnykh 3-oksipiridina na postishemicheskie narusheniia autoreguliatornykh reaktsii mozgovykh sosudov.

Acute experiments on nembutal anesthetized rats showed improvement of cerebral blood flow autoregulation in the postischemic period under the effect of mexidol and the new 3-hydroxypyridine (3-HOP) derivatives LBK-10 and LBK-38 administered for prophylactic and therapeutic, purposes. The role of dopaminergic activity, solubility in lipids, and other factors in the mechanism of the activity of 3-HOP derivatives is analysed.

[The effect of cytochrome c preparations on the autoregulation of the cerebral blood flow in ischemia]. / Vliianie preparatov tsitokhroma c na autoreguliatsiiu mozgovogo krovotoka v usloviiakh ishemii.

The effect of animal cytochrome C (Ca), biotechnological cytochrome (Cb) and its hemtetradecapeptide (HTDP) on cerebral blood flow autoregulation during rapid decrease of systemic arterial pressure (SAP) was studied in acute experiments on rats. Cytochrome C preparations caused no effect on the autoregulatory responses of the cerebral vessels in animals with normal cerebral circulation. Injection of 5 mg/kg Ca and Cb and 0.8 mg/kg HTDP promoted restoration of the phenomenon of cerebral blood flow autoregulation in ischemic brain damage in change of SAP from 120 to 60 mm Hg. Prophylactic injection of 20 mg/kg Ca and Cb and 3.3 mg/kg HTDP prevented cerebral blood flow autoregulation disturbance caused by transitory brain ischemia.

[The effect of lithium derivatives of GABA on blood circulation and metabolic indices in the brain under ischemia]. / Vliianie litievykh proizvodnykh GAMK na krovoobrashchenie i nekotorye pokazateli metabolizma v golovnom mozge v usloviiakh ishemii.

In acute experiments on anesthetized cats with cerebral ischemia in conditions of autohemoperfusion of cerebral and peripheral vessels with a stable volume of blood we found that lithium oxybutirate and new GABA derivatives: LOS 1-84 and LOS 5-79 affect the cerebral blood flow and metabolism in the brain. Prophylactic intravenous injection of lithium oxybutirate did not affect the development of postischemic hyperperfusion but inhibited postischemic hyperperfusion. The compounds prevent the development of postischemic phenomena and promote the recovery of metabolism in the brain.

[The effect of cytochrome c preparations on the cerebral circulation in cerebral ischemia]. / Vliianie preparatov tsitokhroma c na mozgovoe krovoobrashchenie pri ishemii mozga.

Biotechnological cytochrome c, heme-tetradecapeptide (HTDP) and animal cytochrome c were studied for their effects on intact and brain ischemic rats. In the latter case, the compounds were administered before ischemia induction and 15 min after artery ligation. It was found that the cytochrome c preparations did not virtually affect the cerebral circulation in intact rats. In cerebral ischemia, the cytochrome C preparations increased circulation, showing their more profound effects in case of preadministration of the drugs. The dose-independent effects of HTDP may be associated with the higher transmembranous permeability and the saturation phenomenon of this compound.

[Cerebral blood circulation during angiotensin-converting enzyme inhibition]. / Mozgovoe krovoobrashchenie v usloviiakh ingibirovaniia angiotenzin-konvertiruiushchego fermenta.

The inhibitor of angiotensin-converting enzyme captopril does not change the tone of the brain vessels but decreases the blood pressure and the tone of peripheral vessels, increases the oxygen and glucose demand in the brain in intact cats. In animals with brain ischemia, captopril decreased the tone of the brain vessels and promoted normalising of metabolic and transcapillary exchange in the brain.

[Effect of dopamine on the blood circulation and metabolism in the brain during ischemia]. / Vliianie dofamina na krovoobrashchenie i metabolizm v golovnom mozge v usloviiakh ishemii.

In acute experiments on anesthetized cats under blood autoperfusion of cerebral and peripheral vessels with a stable volume of blood during cerebral ischemia there was revealed the vascular and metabolic effects of dopamine on cerebral circulation. Administration of dopamine by perfusion in a dose of 100 micrograms/kg/min for 35 min after ischemia inhibited the development of postischemic hypoperfusion of the brain and also eliminated postischemic hypotension. A significant effect of dopamine on oxidative metabolism of the brain was observed.

[Effect of komplamin and nikoshpan on brain circulation and metabolism in the postischemic period]. / Vliianie komplamina i nikoshpana na krovoobrashchenie i metabolizm golovnogo mozga v postishemicheskom periode.

Intravenous administration of komplamin to anesthetized cats before the brain ischemia or in the early period following ischemia prevents the development of the postischemic phenomenon of the cerebral blood flow nonrecovery and beneficially influences the cerebral metabolism: restores oxygen and glucose consumption by the brain, decreases pyruvic acid level in the arterial and venous blood, attenuates the phenomenon of acidosis. Nikoshpan improves the blood supply to the brain, restores oxygen and glucose consumption by the brain in the postischemic period only if administered before the brain ischemia.

[Effect of euphylline and no-shpa on cerebrovascular resistance and the survivability of animals after cerebral ischemia]. / Vliianie éufillina i no-shpy na tserebrovaskuliarnoe soprotivlenie i vyzhivaemost' zhivotnykh posle ishemii golovnogo mozga.

In acute experiments on anesthetized cats with total ischemia of the brain (15-minute arrest of blood autoperfusion of the cerebral vessels by a stable blood volume) it was shown that euphylline and no-shpa administered before ischemia or in the early period after ischemia inhibit or prevent the development of the postischemic phenomenon of non-recovery of the cerebral blood flow. The two drugs contributed to survival of albino rats following the brain ischemia produced by ligation of both carotid arteries.

[Use of gravitational loads as a screening method in research on new biologically active substances]. / Isplo'zovanie gravitatsionnykh peregruzok v kachestve skriningovoi metodiki issledovaniia novykh biologicheski aktivnykh veshchestv.

The application of longitudinal gravitational overloads in white rats in craniocaudal and caudo-cranial directions modelled on a centrifuge is suggested for the screening of bioactive agents. The time and value of the overload are selected in such a way, as to kill 50% of animals in the control experiments. The same overload is given to animals that have previously received the tested agents. The difference in the survival rate of these animals and the control ones serves as the indicator of activity of the new compounds. This method reflects mainly the functional stability of the system of cerebral circulation.