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5.
Biomed Biochim Acta ; 44(2): 329-33, 1985.
Artículo en Inglés | MEDLINE | ID: mdl-4004836

RESUMEN

The angular psoralen derivative, 4,5'-dimethylangelicin (Dm Agn), both without and with UV-radiation induces under adequate conditions a higher percentage of lethally damaged cultured human polymorphonuclear neutrophils (PMN) as compared with angelicin (Agn). In general, PMN photosensitized with Dm Agn are less resistant than similarly photosensitized lymphocytes. These results suggest that Dm Agn might be used to improve the photochemo (PUVA-)therapy of skin diseases where PMN are of pathogenic importance.


Asunto(s)
Furocumarinas/farmacología , Linfocitos/efectos de los fármacos , Neutrófilos/efectos de los fármacos , Terapia PUVA , Fotoquimioterapia , Supervivencia Celular/efectos de los fármacos , Humanos , Técnicas In Vitro
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