RESUMEN
The study of natural products introduces interesting new bioorganic structures and potential candidates for the drug discovery stage in the development of innovative drugs. Vietnam enjoys a broad biodiversity of native plant species, microorganisms, marine organisms, and a long tradition of using herbal remedies. Thus, the study of medicinal plants in determining the basis of their efficacy and safety is an important task for modern researchers in Vietnam. The present review covers literature on new compounds elucidated from the systematic study of medicinal plants within some popular genera in Vietnam, as well as their significant biological activities.
Asunto(s)
Productos Biológicos/química , Descubrimiento de Drogas , Plantas Medicinales/química , Conformación Molecular , VietnamRESUMEN
Ten known compounds including a chalcone, a long-chain alcohol, two flavonols, and six triterpenoids/steroids together with a new taraxastane-type triterpenoid, named cleistocalyxin, were isolated from the leaves of Cleistocalyx operculatus. The structure of cleistocalyxin was determined on the basis of IR, MS and NMR spectroscopic methods.
Asunto(s)
Syzygium/química , Triterpenos/química , Estructura Molecular , Hojas de la Planta/químicaRESUMEN
Three new eudesmanes, named artemisidiols A-C, together with eight known compounds, were isolated from the leaves of Artemisia japonica Thunb. (Asteraceae). Their structures were determined on the basis of spectroscopic data. Although oxygenated eudesmanes frequently occur in Asteraceae plants, the 1α,6α,8α-oxygenated pattern of artemisidiols A-C has not been previously reported.
Asunto(s)
Artemisia/citología , Sesquiterpenos de Eudesmano/aislamiento & purificación , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Oxígeno/química , Hojas de la Planta/química , Sesquiterpenos de Eudesmano/química , Estereoisomerismo , VietnamRESUMEN
A new member of 5αH,6ßH,7αH,11αH-guaian-12,6α-olides, 11-epi-8α-hydroxyarborescin, together with a mixture of (24R)- and (24S)-cycloart-25-en-3b,24-diols, palmitic acid and 1-octacosanol were isolated from the leaves of Artemisia roxburghiana Bess. (Asteraceae) of Vietnam. Their structures were determined on the basis of spectroscopic methods.
Asunto(s)
Artemisia/química , Extractos Vegetales/análisis , Hojas de la Planta/química , Sesquiterpenos de Guayano/aislamiento & purificación , Cromatografía en Capa Delgada , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Metanol , Estructura Molecular , Ácido Palmítico/aislamiento & purificación , Sesquiterpenos de Guayano/química , Espectroscopía Infrarroja por Transformada de Fourier , VietnamRESUMEN
The chemical constituents of the hydrodistilled essential oil from the bark of Cinnamomum illicioides A. Chev., Lauraceae, from Vietnam, have been studied by GC and GC-MS. Seventeen monoterpenoids, eugenol, and thirty-six sesquiterpenoids, accounting for 25, 41.2, and 27.9% of the oil, respectively, were identified. Terpinen-4-ol (10.4%), eugenol (41.2%), and δ-cadinene (5.6%) are the major components of the oil.
RESUMEN
Two new megastigmane glucosides, called excoecariosides A and B were isolated from the leaves of a medicinal Vietnamese plant, Excoecaria cochinchinensis LOUR. var. cochinchinensis (Euphorbiaceae) together with seven known compounds. Their structures were elucidated by spectroscopic analyses and chemical reactions including the modified Mosher's method.
Asunto(s)
Ciclohexanonas/química , Euphorbiaceae/química , Glucósidos/química , Norisoprenoides/química , Cromatografía Líquida de Alta Presión , Cromatografía en Capa Delgada , Hidrólisis , Espectroscopía de Resonancia Magnética , Extractos Vegetales/análisis , Hojas de la Planta/química , Solventes , Espectrometría de Masa Bombardeada por Átomos Veloces , Espectroscopía Infrarroja por Transformada de Fourier , VietnamRESUMEN
Twelve natural bis-spirolabdane-type diterpenoids, including eight new, named leoheteronones A-E, 15-epileoheteronones B, D, and E, and four known leopersin B, 15-epileopersin B, leopersin C, and 15-epileopersin C, together with hispanone and galeopsin were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus SW. (Lamiaceae) grown in Vietnam. Their structures were determined by spectroscopic analyses. The current study emphasized the accumulation of C-15 oxygenated bis-spirolabdane-type diterpenoids of both 13R and 13S configurations in L. heterophyllus.
Asunto(s)
Diterpenos/química , Leonurus/química , Cromatografía en Capa Delgada , Espectroscopía de Resonancia Magnética , Espectrometría de Masa Bombardeada por Átomos VelocesRESUMEN
From the leaves of the endemic Vietnamese medicinal plant Croton tonkinensis GAGNEP. (Euphorbiaceae) the four new ent-kaurane-type diterpenoids ent-1alpha,14alpha-diacetoxy-7beta-hydroxykaur-16-en-15-one (1), ent-1alpha,7beta-diacetoxy-14alpha-hydroxykaur-16-en-15-one (2), ent-18-acetoxy-14alpha-hydroxykaur-16-en-15-one (3), and ent-(16S)-18-acetoxy-7beta-hydroxykauran-15-one (4) were isolated. Their structures were elucidated by spectroscopic analyses.
Asunto(s)
Croton , Diterpenos de Tipo Kaurano/química , Diterpenos de Tipo Kaurano/aislamiento & purificación , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Hojas de la PlantaRESUMEN
Four ent-kaurane diterpenoids including two known, ent-7alpha,14beta-dihydroxykaur-16-en-15-one (1) and ent-18-acetoxy-7alpha-hydroxykaur-16-en-5-one (2), and two new, ent-1beta-acetoxy-7alpha,14beta-dihydroxykaur-16-en-15-one (3) and ent-18-acetoxy-7alpha,14beta-dihydroxykaur-16-en-15-one (4), were isolated from the leaves of Croton tonkinensis in a search for inhibitors of NF-kappaB activation and nitric oxide production. These ent-kauranoids inhibited LPS-induced NF-kappaB activation in murine macrophage RAW264.7 cells at IC50 values between 0.07 and 0.42 microM. Consistently, the ent-kauranoids markedly reduced LPS-induced NO production in a comparable concentration-dependent manner.