RESUMEN
Intradermal therapy, known as mesotherapy, is a technique used to inject a drug into the surface layer of the skin. In particular, it involves the use of a short needle to deposit the drug in the dermis. The intradermal microdeposit modulates the drug's kinetics, slowing absorption and prolonging the local mechanism of action. It is successfully applied in the treatment of some forms of localized pain syndromes and other local clinical conditions. It could be suggested when a systemic drug-sparing effect is useful, when other therapies have failed (or cannot be used), and when it can synergize with other pharmacological or nonpharmacological therapies. Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. The Italian Mesotherapy Society proposes this position paper to apply intradermal therapy based on scientific evidence and no longer on personal bias.
Asunto(s)
Analgésicos/administración & dosificación , Dermis/metabolismo , Mesoterapia/métodos , Dolor/prevención & control , Absorción Cutánea , Analgésicos/farmacocinética , Animales , Predicción , Humanos , Inyecciones Intradérmicas , Italia , Mesoterapia/instrumentación , Mesoterapia/tendencias , Guías de Práctica Clínica como Asunto , Resultado del TratamientoRESUMEN
Over the last decade, the Italian National Health Service has been widely criticized for failing to meet the expectations of the Italian population and to reduce the weaknesses of the health care system deriving from a lack of balance between increasing costs and comparable benefits. In order to improve health care services, a new model of acute care hospitals, characterized mainly by new structures, high technology, integration and collaboration among professionals, are necessary. The traditional concept of specialized operative unit is thus overcome by a new hospital organization in which specific functions are performed in shared facility areas. In particular, the role of the nephrologists will be reorganized into different health care settings according to the level of intensity of care: high level (intensive care unit, organ transplantation), intermediate level (medical area) or low intensity care facilities (day hospital, day surgery, day service, ambulatory).