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1.
Molecules ; 27(23)2022 Nov 26.
Artículo en Inglés | MEDLINE | ID: mdl-36500338

RESUMEN

Plant extracts are increasingly tested for their biological activity and interactions with neoplastic cells. One of such sources of biologically active substances is propolis. This product has been known for thousands of years and is widely used in alternative, folk medicine. Articles describing its effects on the metabolism and cell signaling pathways of neoplastic cells derived from different organs are also published more and more frequently. The purpose of our study was to evaluate the biological activity of propolis extract produced with the cold separation method into hormone-dependent and hormone-independent prostate cancer cell lines. In our study, the propolis extracts showed at least an inhibitory effect on the growth of PC-3 and DU-145 neoplastic cells. Our results suggest that propolis extracts obtained with the cold separation method may be considered as promising compounds for the production of health-promoting supplements.


Asunto(s)
Própolis , Neoplasias de la Próstata , Masculino , Humanos , Própolis/farmacología , Proliferación Celular , Extractos Vegetales/farmacología , Neoplasias de la Próstata/tratamiento farmacológico , Línea Celular , Hormonas/farmacología
2.
Molecules ; 27(3)2022 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-35163884

RESUMEN

Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts and roots of Alchemilla acutiloba led to the identification of phenolic acids and flavonoids. To the best of our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, narcissoside, naringenin 7-glucoside, 3-O-methylquercetin, naringenin, eriodictyol, rhamnetin, and isorhamnetin were described for the first time in Alchemilla genus. In addition, the antioxidant, anti-inflammatory and cytotoxic activity of all extracts were evaluated. The results clearly showed that among analyzed extracts, the butanol extract of the aerial parts exhibited the highest biological activity comparable with the positive controls used.


Asunto(s)
Alchemilla/química , Antiinflamatorios/farmacología , Antioxidantes/farmacología , Citotoxinas/farmacología , Flavonoides/farmacología , Fenoles/análisis , Extractos Vegetales/análisis , Animales , Cromatografía Liquida , Flavonoides/análisis , Haplorrinos , Riñón/efectos de los fármacos , Riñón/patología , Extractos Vegetales/farmacología , Espectrometría de Masa por Ionización de Electrospray , Espectrometría de Masas en Tándem
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