[Hyperbaric oxygenation as a method of intensive therapy in acute exogenous poisoning]. / Giperbaricheskaia oksigenatsiia kak metod intensivnoi terapii pri ostrykh ékzogennykh otravleniiakh.

Hyperbaric oxygenation (HBO) was used in intensive care of patients with acute exogenous poisonings. Impaired oxygen homeostasis was pathogenetically significant, irrespective of the toxic agent. HBO added to a complex of intensive care measures was pathogenetically justified and promoted normalization of clinical and biochemical parameters of homeostasis.

[Role of hyperbaric oxygenation in the treatment of posthypoxic encephalopathy of toxic etiology]. / Rol' giperbaricheskoi oksigenatsii v lechenii postgipoksicheskoi éntsefalopatii toksicheskogo geneza.

Hyperbaric oxygenation (HBO) was used in the treatment of 475 patients with toxic encephalopathy (TE) developing as a result of exo- and endotoxicosis. HBO promoted correction of all components of homeostasis, decreased endotoxicosis, reduced psychopathological and neurological disorders, and promoted social adaptation.

[Effect of the angiotensin-converting enzyme inhibitor ramipril on the processes of lipid peroxidation on the status of the endogenous antioxidant system in patients with myocardial infarction]. / Vliianie ingibitora angiotenzin-prevrashchaiushchego fermenta ramiprila na protsessy perekisnogo okiseleniia lipidov i sostoianie éndogennoi antioksidantnoi sistemy u bol'nykh s infarktom miokarda.

57 patients with macrofocal through-and-through myocardial infarction (MI) formed two groups. The control one (37 patients) received conventional treatment and the study one (20 patients) received adjuvant ramipril beginning from day 1 of MI and over the observation period. The patients were examined on day 1, 3, 10 and 20 from the moment of admission. MI patients of all the studied groups exhibited high level of lipid peroxidation (LP) products in the serum. Ramipril treatment produced marked correcting influence on conjugated dienes, malonic dialdehyde and degree of lipid oxidation. In MI patients on ramipril conjugated dienes level was the lowest on MI day 1-3, and malonic dialdehyde on MI day 10-20. Ramipril treatment limited alpha-tocopherol and ceruloplasmin increase in the serum. It is shown that in the mechanism of a positive effect of angiotensin-converting enzyme inhibitors in MI not only their direct pharmacological action can be involved but also a correction of LP processes and antioxidant system disturbances.

[Individual patient sensitivity to glucocorticoids and hormone resistance in bronchial asthma]. / Individual'naia chuvstvitel'nost' bol'nykh k gliukokortikoidam i gormonorezistentnost' pri bronkhial'noi astme.

The paper reports glucocorticoid actions in bronchial asthma, covers problems of individual sensitivity to glucocorticoids and resistance to hormones, illustrates the dependence of beclometasone dipropionate efficacy on condition of glucocorticoid receptors in alveolar macrophages and clinical appearance of the disease, describes physiological features of patients with hormone-resistant bronchial asthma and its new treatment (extracorporeal photohemotherapy) allowing reduction of prednisolone dose in 14 of 15 patients from 29.6 to 11.4 mg/day, on the average.

[Effect of hyperbaric oxygenation on the corticosterone content of the blood in experimental acute respiratory distress syndrome]. / Vliianie giperbaricheskoi oksigenatsii na soderzhanie kortikosterone v krovi pri ostrom respiratornom distress-sindrome v éksperimente.

The three series of experiments conducted on 139 adult wistar rats it was found, that two-hour stay of the animals in barochamber under the pressure of 3 atmospheres reduces considerably the percentage of mortality rate and decelerates the development of arterial hypoxemia in rats with an experimental model of acute respiratory distress syndrome (ARDS) reproduced by intrapleural injection of oleic acid (0.27 ml/100 g). Stalle in comparison with the control (I) series elevation of corticosterone in the animal blood II and III series (conduction of HBO correspondingly in 4 and 12 hours from the beginning of the process) is considered as the manifestation of one of the most important mechanism of organism adaptation to the development of acute hypoxia in ARDS.

[Use of infrared ray laser irradiation in the rehabilitation treatment of patients with long-term crush syndrome in an emergency care hospital]. / Primenenie infrakrasnogo lazernogo izlucheniia pri vosstanovite'l- nom lechenii bo'lnykh s sindromom dlite'lnogo razdavlivaniia v usloviiakh statsionara skoroi pomoshchi.

The principle 'rehabilitation starts in a resuscitation ward' has been realized in the resuscitation treatment of 34 patients with the prolonged crush syndrome (PCS) who were injured during the earthquake in Armenia. Laser therapy has been fairly effective, normalizing the external respiration function and central hemodynamics and reducing the blood coagulability. Instrumental vibration massage and acupuncture are recommended to be added to rehabilitation treatment of PCS patients.