Improved Measurement of the Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay.

Reactor neutrino experiments play a crucial role in advancing our knowledge of neutrinos. In this Letter, the evolution of the flux and spectrum as a function of the reactor isotopic content is reported in terms of the inverse-beta-decay yield at Daya Bay with 1958 days of data and improved systematic uncertainties. These measurements are compared with two signature model predictions: the Huber-Mueller model based on the conversion method and the SM2018 model based on the summation method. The measured average flux and spectrum, as well as the flux evolution with the ^{239}Pu isotopic fraction, are inconsistent with the predictions of the Huber-Mueller model. In contrast, the SM2018 model is shown to agree with the average flux and its evolution but fails to describe the energy spectrum. Altering the predicted inverse-beta-decay spectrum from ^{239}Pu fission does not improve the agreement with the measurement for either model. The models can be brought into better agreement with the measurements if either the predicted spectrum due to ^{235}U fission is changed or the predicted ^{235}U, ^{238}U, ^{239}Pu, and ^{241}Pu spectra are changed in equal measure.

[The effect of hyperbaric oxygenation on the microcirculation, oxygen budget and acid-base equilibrium in patients with diabetic angiopathy of the lower extremities]. / Vliianie giperbaricheskoi oksigenatsii na mikrotsirkuliatsiiu, kislorodnyi biudzhet i kislotno-shchelochnoe ravnovesie u bol'nykh s diabeticheskoi angiopatiei nizhnikh konechnostei.

These effects were studied in 52 patients with degrees III-IV diabetic angiopathies of the lower limbs. Microcirculation parameters were found changed in this patient population, this leading to disorders of the oxygen budget and development of metabolic acidosis. Development of destructive changes in the limb evidences failure of the compensatory adaptive mechanisms of microcirculation. Addition of hyperbaric oxygenation to multiple-modality treatment of patients with diabetic angiopathies was conducive to improvement of the blood rheology, of tissue saturation with oxygen, and to essential reduction of metabolic acidosis. The detected microcirculation disorders necessitate addition to the therapeutic complex of the drugs improving the biophysical characteristics of the blood.

[Oxygen exchange and acid-base status in patients with diabetic angiopathy of the lower extremities with different methods of conservative treatment]. / Kysnevyi obmin i kyslotno-osnovnyi stan u khvorykh na diabeyychnu angiopatyiu nyzhnikh kintsivok pry riznykh metodakh ïï konservatyvnogo likuvannia.

In the pathogenesis of III-IV stage diabetic angiopathy, the important place belongs to oxygen deficiency and metabolic acidosis. Introduction into the complex of treatment of the patients of hyperbaric oxygenation and endolymphatic pharmacotherapy contributes to improvement of general state of the patients, alleviation of the course of destructive processes on the extremities, rapid normalization of oxygen exchange in the organism, liquidation of the phenomena of metabolic acidosis. This results in shortening of patients' stay in a hospital and permits to avoid, or postpone performance of amputation of an extremity.

[The effect of hyperbaric oxygenation on the rheologic properties of the blood and its coagulation and anticoagulation system in patients with diabetic angiopathy of the lower extremities]. / Vplyv giperbarychnoï oksygenatsiï na reologichni vlastyvosti krovi ta ïï zcidal'nu i protizsidal'nu systemy u khvorykh na diabetychnu angiopatiiu nyzhnikh kintsivok.

In 24 patients with III degree diabetic angiopathy of the lower extremities, the changes in rheologic properties of the blood, its coagulative and anticoagulative system under the influence of hyperbaric oxygenation were studied. Hyperbaric oxygenation facilitates the rapid normalization of rheologic properties and general coagulative activity of the blood. Anticoagulative blood system is activated insufficiently, especially fibrinolysis, and that is why it is necessary to prescribe heparin to the patients, and at the necrotic stage, fibrinolysin as well.

[Equine pepsins]. / Issledovanie pepsinov loshadi

6 forms of pepsin are found in horse gastric juice. Amino acid sequence is determined of N-terminal (most variable) part of polypeptide chain of main pepsin components. Equine pepsines, which have pI 2.1 and 2.3, are found to have identical amino acid sequence at least for 31 amino acid residues. The same sequence is observed in the component with pI 2.6 for 10 first residues. The sequence of equine pepsin with pI 3.2 has 3 substitutions for 33 amino acids, when compared with pepsines having pI 2.1 and 2.3. The forms of equine pepsin studied are more similar than the other isoenzyme pair, human pepsin and gastricsin.