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Int J Biochem Cell Biol ; 39(3): 469-77, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17137828

RESUMEN

Duchenne muscular dystrophy is a lethal X-linked muscle disease resulting from a defect in the muscle membrane protein dystrophin. The absence of dystrophin leads to muscle membrane fragility, muscle death (necrosis) and eventual replacement of skeletal muscle by fat and fibrous connective tissue. Extensive muscle wasting and respiratory failure results in premature death often by the early 20s. This short review evaluates drug and nutritional interventions designed to reduce the severity of muscular dystrophy, while awaiting the outcome of research into therapies to correct the fundamental gene defect. Combinations of dietary supplementation with amino-acids such as creatine, specific anti-inflammatory drugs and perhaps drugs that target ion channels might have immediate realistic clinical benefits although rigorous research is required to determine optimal combinations of such interventions.


Asunto(s)
Distrofia Muscular de Duchenne/dietoterapia , Distrofia Muscular de Duchenne/tratamiento farmacológico , Corticoesteroides/uso terapéutico , Agonistas Adrenérgicos beta/uso terapéutico , Animales , Antiinflamatorios/uso terapéutico , Citocinas/antagonistas & inhibidores , Suplementos Dietéticos , Humanos , Canales Iónicos/metabolismo , Ratones , Ratones Endogámicos mdx , Distrofia Muscular Animal/dietoterapia , Distrofia Muscular Animal/tratamiento farmacológico , Inhibidores de Proteasas/uso terapéutico
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