Effects of oral nutritional supplements on the nutritional status and inflammatory markers in patients on maintenance dialysis: a systematic review and meta-analysis of randomized clinical trials.

Background and aims: Patients on hemodialysis (HD) or peritoneal dialysis (PD) often have insufficient energy and protein intake, resulting in poor nutritional status and adverse outcomes. Oral nutritional supplements (ONSs) are the most commonly used to increase such patients' energy and protein intakes. Methods: In this systematic review and meta-analysis, we analyzed studies on nutritional status, inflammatory markers, and electrolyte levels in patients on dialysis receiving ONSs. We searched four electronic databases from inception until 31 December 2022, for randomized controlled trials comparing ONS treatment versus placebo or routine care. Results: 22 studies with 1185 patients on dialysis were included in our meta-analysis. Compared with the control group, the ONS group exhibited significantly increased serum albumin levels [1.26 g/l (95%CI, 0.50-2.02, P < 0.0001; I2 = 80.4%)], body mass indexes (BMIs) [0.30 kg/m2 (95%CI, 0.09-0.52, P = 0.005; I2 = 41.4%)], and handgrip strength (HGS) [0.96 kg (95%CI, 0.07-1.84, P = 0.034; I2 = 41.4%)] from baseline to the end of intervention. No significant differences were observed between the groups in lean body mass, phase angle, C-reactive protein, and serum phosphorus and potassium levels. In terms of improving albumin, the subgroup analyses show that ONS use seems to be more inclined to three variations: HD patients, short-term use, and non-intradialytic supplementation. Conclusion: In conclusion, ONS use can improve the nutritional status of patients on dialysis in terms of their serum albumin, BMI, and HGS without significant effects on serum phosphorus, potassium, and C-reactive protein levels. However, it remains uncertain whether these results translate to improvement in clinically relevant outcomes. Large-scale high-quality studies are still required in this population.

Physiological Effects of a Garden Plant Smellscape from the Perspective of Perceptual Interaction.

The purpose of this study was to investigate the physiological recovery effects of olfactory, visual and olfactory-visual stimuli associated with garden plants. In a randomized controlled study design, ninety-five Chinese university students were randomly selected to be exposed to stimulus materials, namely the odor of Osmanthus fragrans and a corresponding panoramic image of a landscape featuring the plant. Physiological indexes were measured by the VISHEEW multiparameter biofeedback instrument and a NeuroSky EEG tester in a virtual simulation laboratory. The results showed the following: (1) In the olfactory stimulation group, from before to during exposure to the stimuli, the subjects' diastolic blood pressure (DBP) (ΔDBP = 4.37 ± 1.69 mmHg, p < 0.05) and pulse pressure (PP) values increased (ΔPP = -4.56 ± 1.24 mmHg, p < 0.05), while their pulse (p) values decreased (ΔP = -2.34 ± 1.16 bmp, p < 0.05) significantly. When compared to the control group, only the amplitudes of α and ß brainwaves increased significantly (Δα = 0.37 ± 2.09 µV, Δß = 0.34 ± 1.01 µV, p < 0.05). (2) In the visual stimulation group, the amplitudes of skin conductance (SC) (ΔSC = 0.19 ± 0.01 µΩ, p < 0.05), α brainwaves (Δα = 6.2 ± 2.26 µV, p < 0.05) and ß brainwaves (Δß = 5.51 ± 1.7 µV, p < 0.05) all increased significantly relative to the control group. (3) In the olfactory-visual stimulus group, DBP (ΔDBP = 3.26 ± 0.45 mmHg, p < 0.05) values increased, and PP values decreased (ΔPP = -3.48 ± 0.33 bmp, p < 0.05) significantly from before to during exposure to the stimuli. The amplitudes of SC (ΔSC = 0.45 ± 0.34 µΩ, p < 0.05), α brainwaves (Δα = 2.28 ± 1.74 µV, p < 0.05) and ß brainwaves (Δß = 1.4 ± 0.52 µV, p < 0.05) all increased significantly relative to the control group. The results of this study show that the interaction of olfactory and visual stimuli associated with a garden plant odor landscape was able to relax and refresh the body to a certain extent, and this physiological health effect was greater with regards to the integrated response of the autonomic nervous system and central nervous system than the effect of only smelling or viewing the stimuli. In the planning and designing of plant smellscapes in garden green space, it should be ensured that plant odors and corresponding landscapes are present at the same time in order to ensure the best health effect.

Mechanism of ASK1 involvement in liver diseases and related potential therapeutic targets: A critical pathway molecule worth investigating.

Since the discovery of apoptosis signal-regulated kinase 1 (ASK1), the signal transduction mechanism and pathophysiological process involved in its regulation have been continuously revealed. Many previous studies have identified that ASK1 is involved and plays a critical role in the development of diseases affecting the nervous, cardiac, renal, and other systems. As a mitogen-activated protein kinase (MAPK) kinase kinase, ASK1 mediates apoptosis, necrosis, inflammation, and other pathological processes by activating its downstream c-Jun N-terminal kinase (JNK)/p38 MAPK. Owing to the important role of ASK1, an increasing number of studies in recent years have focused on its status in liver-related diseases. In this paper, we review the mechanisms and targets of ASK1 in liver-related diseases to emphasize its important role in the development of liver disease.

Sterilization of polydimethylsiloxane surface with Chinese herb extract: a new antibiotic mechanism of chlorogenic acid.

Coating of polydimethylsiloxane (PDMS) surface with a traditional Chinese herb extract chlorogenic acid (CA) solves the contemporary problem of sterilization of PDMS surface. The E. coli grows slower and has a higher death rate on the CA-coated PDMS surfaces. A smoother morphology of these E. coli cell wall is observed by atomic force microscopy (AFM). Unlike the reported mechanism, where CA inhibits bacterial growth by damaging the cell membrane in the bulk solution, we find the CA-coated PDMS surface also decreases the stiffness of the cell wall. A decrease in the Young's modulus of the cell wall from 3 to 0.8 MPa is reported. Unexpectedly, the CA effect on the swarming ability and the biofilm stability of the bacteria can be still observed, even after they have been removed from the CA environment, indicating a decrease in their resistance to antibiotics for a prolonged time. The CA-coated PDMS surface shows better antibiotic effect against three types of both Gram-positive and Gran-negative bacteria than the gentamicin-coated PDMS surface. Coating of CA on PDMS surface not only solves the problem of sterilization of PDMS surface, but also shines light on the application of Chinese traditional herbs in scientific research.