RESUMEN
The flowers of Nyctanthes arbor-tristis showed interesting antibacterial activity against some gram-positive and gram-negative microorganisms (chloroform and ethyl acetate extracts) and significant cytotoxic activity (petroleum ether, chloroform and ethyl acetate extracts).
Asunto(s)
Antibacterianos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Magnoliopsida , Plantas Medicinales , Animales , Artemia/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/farmacologíaRESUMEN
The extracts of Trapa bispinosa showed interesting antimicrobial activity against Gram-positive and Gram-negative test organisms and significant cytotoxic activity.
Asunto(s)
Antibacterianos/farmacología , Artemia/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Extractos Vegetales/farmacología , Plantas Medicinales/química , Animales , Antibacterianos/toxicidad , Humanos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/toxicidadRESUMEN
Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O-beta-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of "akond mul" (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 micrograms/ml.