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1.
Biol Trace Elem Res ; 143(2): 871-81, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-21120705

RESUMEN

To examine whether there were gender differences in the sino-atrial node (SAN), the authors investigated the gender difference in the SAN using monkey hearts by direct chemical analysis from a viewpoint of element contents. The used rhesus and Japanese monkeys consisted of 30 males (average age=6.5±7.5 years) and 30 females (average age=12.2±10.3 years), ranging in age from newborn to 30 years. The SAN tissues were removed from the anatomical position of monkey hearts and were confirmed by means of histological observation. After ashing with nitric acid and with perchloric acid, element contents of the SANs, such as Ca, P, S, Mg, Zn, Fe, and Na, were determined by inductively coupled plasma-atomic emission spectrometry. In addition, gender differences in the right atrial walls, left ventricular walls, mitral valves, and left coronary arteries of monkeys were also investigated as controls. It was found that the P content was significantly higher in females than in males in the SANs of monkeys, but the other six element contents, Ca, S, Mg, Zn, Fe, and Na, were not significantly different between males and females in the SANs of monkeys. Regarding the P content, a similar finding was also obtained in both the right atrial walls and the left ventricular walls of monkeys, but it was not obtained in the mitral valves and the left coronary arteries of monkeys. The P content of tissue is mostly determined by the nucleic acid (DNA and RNA) content and the phospholipid content of tissue. Nucleic acids in the cell nucleus and the cytosol, and phospholipids in the cell membrane are all indicators of metabolically active cells. It is reasonable to presume that the P content in the SAN indicates the active cell density, namely, the number of active cells per volume. Therefore, there is a possibility that the active cell density of the SAN is significantly higher in females than in males.


Asunto(s)
Fósforo/análisis , Nodo Sinoatrial/química , Animales , Calcio/análisis , Femenino , Haplorrinos , Atrios Cardíacos/química , Ventrículos Cardíacos/química , Hierro/análisis , Magnesio/análisis , Masculino , Factores Sexuales , Sodio/análisis , Azufre/análisis
2.
Biol Trace Elem Res ; 133(3): 291-303, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-19618135

RESUMEN

To elucidate compositional changes of the tendon of the peroneus longus muscle with aging, the authors investigated age-related changes of elements in the insertion of tendons of the peroneus longus muscle (peroneus longus tendons) in Thai, Japanese, and monkeys and the relationships among element contents by direct chemical analysis. After ordinary dissections at Chiang Mai University and Nara Medical University were finished, the peroneus longus tendons were resected from the subjects. The peroneus longus tendons were also resected from rhesus and Japanese monkeys bred in Primate Research Institute, Kyoto University. The wraparound regions of the insertion tendons of the peroneus longus muscle in contact with the cuboid bone were used as the peroneus longus tendon. After ashing with nitric acid and perchloric acid, element contents were determined with an inductively coupled plasma-atomic emission spectrometer. It was found that there were no significant correlations between age and the seven elements, such as Ca, P, S, Mg, Zn, Fe, and Na, in the peroneus longus tendons of Thai and Japanese. The Ca content higher than 10 mg/g was contained in seven cases out of 34 peroneus longus tendons of Thai (incidence = 20.6%) and in one case out of 22 peroneus longus tendons of Japanese (incidence = 4.5%), respectively. All of the peroneus longus tendons with the Ca content higher than 10 mg/g were found in Thai and Japanese men. In the peroneus longus tendons of monkeys, the Ca and P content increased suddenly at 2 years of age and reached to about 40 mg/g at 5 years of age. Thereafter, the Ca and P content did not increase in the peroneus longus tendons of monkeys at old age. Regarding the relationships among element contents, significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in Thai and monkeys, whereas significant inverse correlations were found between S and element contents, such as Ca, P, Mg, Zn, and Na, in Thai and monkeys.


Asunto(s)
Músculo Esquelético/metabolismo , Tendones/metabolismo , Oligoelementos/metabolismo , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Animales , Calcio/metabolismo , Femenino , Haplorrinos , Humanos , Japón , Macaca mulatta , Masculino , Persona de Mediana Edad , Fósforo/metabolismo , Espectrofotometría Atómica/métodos , Tailandia
3.
J Comp Neurol ; 509(2): 180-9, 2008 Jul 10.
Artículo en Inglés | MEDLINE | ID: mdl-18461604

RESUMEN

By using the developing monkey brain as a model for human development, we investigated the expression pattern of the FOXP2 gene, a member of the FOX family of transcription factors in the developing monkey brain, and compared its expression pattern with transcription factors PBX3, MEIS2, and FOXP1. We observed FOXP2 mRNA expression in several brain structures, including the striatum, the islands of Calleja and other basal forebrain regions, the cerebral cortex, and the thalamus. FOXP2 mRNA was preferentially expressed in striosomal compartments during striatal development. The striosomal expression was transient and developmentally down-regulated in a topographical order. Specifically, during the perinatal state, striosomal FOXP2 expression was detected in both the caudate nucleus and the putamen, although expression was more prominent in the caudate nucleus than in the putamen. Striosomal FOXP2 expression declined during the postnatal period, first in the putamen and later in the caudate nucleus. During the same period, we also detected PBX3 mRNA in the striosomal compartment of the developing monkey striatum. FOXP2, as well as PBX3 and MEIS2, was expressed in the islands of Calleja and other cell clusters of the basal forebrain. FOXP2, in combination with PBX3 and MEIS2, may play a pivotal role in the development of striosomal neurons of the striatum and the islands of Calleja.


Asunto(s)
Factores de Transcripción Forkhead/biosíntesis , Regulación del Desarrollo de la Expresión Génica , Proteínas de Homeodominio/biosíntesis , Macaca/genética , Proteínas del Tejido Nervioso/biosíntesis , Prosencéfalo/metabolismo , Proteínas Proto-Oncogénicas/biosíntesis , Animales , Corteza Cerebral/embriología , Corteza Cerebral/crecimiento & desarrollo , Corteza Cerebral/metabolismo , Cuerpo Estriado/embriología , Cuerpo Estriado/crecimiento & desarrollo , Cuerpo Estriado/metabolismo , Femenino , Factores de Transcripción Forkhead/genética , Hipocampo/embriología , Hipocampo/crecimiento & desarrollo , Hipocampo/metabolismo , Proteínas de Homeodominio/genética , Hibridación in Situ , Macaca/embriología , Macaca/crecimiento & desarrollo , Masculino , Proteínas del Tejido Nervioso/genética , Especificidad de Órganos , Prosencéfalo/embriología , Prosencéfalo/crecimiento & desarrollo , Precursores de Proteínas/biosíntesis , Precursores de Proteínas/genética , Proteínas Proto-Oncogénicas/genética , ARN Mensajero/biosíntesis , ARN Mensajero/genética , Ratas , Tabique del Cerebro/embriología , Tabique del Cerebro/crecimiento & desarrollo , Tabique del Cerebro/metabolismo , Especificidad de la Especie , Taquicininas/biosíntesis , Taquicininas/genética , Tálamo/embriología , Tálamo/crecimiento & desarrollo , Tálamo/metabolismo , Factores de Transcripción/biosíntesis , Factores de Transcripción/genética
4.
Biol Trace Elem Res ; 110(3): 233-49, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16845160

RESUMEN

To elucidate compositional changes of the cardiac walls with development and aging, the authors investigated changes of elements in the atrial and ventricular walls of monkeys. The left and right atrial walls, left and right ventricular walls, and interatrial and interventricular septa were resected from the subjects. The subjects consisted of 17 rhesus and 13 Japanese monkeys, ranging in age from 10 d to 33 yr. The element content of the cardiac walls was analyzed by inductively coupled plasma-atomic emission spectrometry. The Ca and P contents decreased in all of the left and right atrial and ventricular walls, interatrial septa, and interventricular septa with development, whereas the S and Mg contents decreased in the left and right ventricular walls with development. Regarding the relationships among elements, significant direct correlations were found among Ca, P, Mg, and Zn in all of the left and right atrial walls, left and right ventricular walls, and interatrial and interventricular septa, with some exceptions. As Ca decreased in the cardic walls, P, Mg, and Zn decreased simultaneously in the cardiac walls. The mass ratio of Ca/P decreased gradually with Ca decrease in both the atrial and ventricular walls, but it was not constant.


Asunto(s)
Envejecimiento/metabolismo , Calcio/metabolismo , Miocardio/metabolismo , Fósforo/metabolismo , Animales , Hierro/metabolismo , Macaca , Macaca mulatta , Sodio/metabolismo
5.
Biol Trace Elem Res ; 106(3): 231-45, 2005 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-16141471

RESUMEN

To elucidate compositional changes of the cardiac valves in monkey with aging, the authors investigated age-related changes of elements in the four cardiac valves of rhesus and Japanese monkeys and the relationships among elements by inductively coupled plasma-atomic emission spectrometry (ICP-AES). The four cardiac valves of the aortic, pulmonary, mitral, and tricuspid valves were resected from 19 rhesus and 11 Japanese monkeys, ranging in age from 10 d to 33 yr. The element contents were determined by ICP-AES. It was found that the Ca, P, S, and Zn contents were high in the four cardiac valves of the monkeys below 1 yr and thereafter decreased significantly with aging, except for Ca in the mitral valve, for which no significant correlation was found between age and Ca content. The Ca and P contents did not increase in the four cardiac valves at old age. This result revealed that calcification scarcely occurred in the four cardiac valves at old age. With regard to the relationships among elements, it was found that there were significant direct correlations among the Ca, P, S, and Zn contents in all of the four cardiac valves of the monkeys, with two exceptions between P and Zn contents in both the aortic and pulmonary valves. Therefore, as Ca decreased in the four cardiac valves, P, S, and Zn decreased simultaneously in the same cardiac valves.


Asunto(s)
Calcio/farmacocinética , Válvulas Cardíacas/química , Fósforo/farmacocinética , Azufre/farmacocinética , Zinc/farmacocinética , Envejecimiento/fisiología , Animales , Macaca/fisiología , Macaca mulatta/fisiología , Espectrofotometría Atómica
6.
Biol Trace Elem Res ; 107(1): 43-52, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16170221

RESUMEN

Changes in trace elements of the sino-atrial (SA) node with aging was investigated using 24 hearts of the Japanese and rhesus monkeys of ages ranging from 27 d to 30 yr. With aging, sympathetic activity decreases and SA nodal function deteriorates. The SA nodal tissue was removed from the anatomical position and was confirmed by means of histological observation. The elements, such as Ca, P, S, Mg, Na, Fe, and Zn, were analyzed using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Advancing age never increased the contents of the trace elements, but decreased them. The correlation coefficients for the age-dependent attenuations were -0.561 (n = 24, p < 0.01) in Ca and -0.482 (n = 24, p < 0.05) in P. The correlations for the attenuations induced by other trace elements were not significant. Furthermore, close relationships of the elements between Ca and P, S, Zn, or Na contents, between P and Zn or Na contents, and between Zn and Na contents were observed. These results indicate that the elements in the monkey SA node are attenuated with an increase in age, presumably suggesting the age-related suppression of cardiac functions as a result of the histological alterations of the SA nodal cells.


Asunto(s)
Metales Alcalinotérreos/análisis , Metales Pesados/análisis , Fósforo/análisis , Nodo Sinoatrial/química , Sodio/análisis , Azufre/análisis , Envejecimiento/metabolismo , Animales , Calcio/análisis , Hierro/análisis , Japón , Macaca , Macaca mulatta , Magnesio/análisis , Nodo Sinoatrial/fisiología , Zinc/análisis
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