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Biomed Chromatogr ; 21(2): 164-8, 2007 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17146762

RESUMEN

In numerous studies it has been demonstrated that several nutritional supplements contain prohormones not declared on the label. In the current study two products (effervescent tablets) containing high amounts of the 17-methylated anabolic androgenic steroids metandienone (product 1: 16.8 mg/tablet) and stanozolol (product 2: 14.5 mg/tablet) were identified. Additionally in both products norandrostenedione was detected, in product 2 with minor amounts of several other steroids. The substances identified can cause enormous health risks. In addition, the use of the analyzed tablets can lead to positive doping results for metabolites of the respective steroids in sports. This study again shows the insufficient surveillance of the production and trade of dietary supplements. Consumers should be aware of the enormous health and doping risks connected with the use of such products. For GC-MS identification of the analytes the trimethylsilyl derivatives of the steroids and the mixed N-t-butyldimethylsilyl,O-trimethylsilyl derivatives were used. The quantitation of metandienone, norandrostenedione, and stanozolol was performed using HPLC-DAD.


Asunto(s)
Anabolizantes/análisis , Andrógenos/análisis , Suplementos Dietéticos/análisis , Metandrostenolona/análisis , Estanozolol/análisis , Cromatografía Líquida de Alta Presión/métodos , Suplementos Dietéticos/normas , Doping en los Deportes/prevención & control , Cromatografía de Gases y Espectrometría de Masas/métodos , Compuestos de Trimetilsililo/análisis , Compuestos de Trimetilsililo/química
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