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Métodos Terapéuticos y Terapias MTCI
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1.
Biomed Pharmacother ; 165: 115244, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37516021

RESUMEN

Alzheimer's disease (AD), the most frequent cause of dementia, is a neurodegenerative disorder characterised by a progressive decline in cognitive function that is associated with the formation of amyloid beta plaques and neurofibrillary tangles. Gut microbiota comprises of a complex community of microorganisms residing in the gastrointestinal ecosystem. These microorganisms can participate in gut-brain axis activities, thereby affecting cognitive function and associated behaviours. Increasing evidence has indicated that gut dysbiosis can jeopardise host immune responses and promote inflammation, which may be an initiating factor for the onset and evolution of AD. Traditional Chinese medicine (TCM) is a promising resource which encompasses immense chemical diversity and multiple-target characteristics for the treatment of AD. Many TCMs regulate the gut microbiota during treatment of diseases, indicating that gut microbiota may be an important target for TCM efficacy. In this review, we summarised the role of the microbiota-gut-brain axis in the development of AD and the effects of TCM in treating AD by regulating the gut microbiota. We anticipate that this review will provide novel perspectives and strategies for future AD research and treatments.


Asunto(s)
Enfermedad de Alzheimer , Humanos , Enfermedad de Alzheimer/tratamiento farmacológico , Eje Cerebro-Intestino , Encéfalo , Péptidos beta-Amiloides , Medicina Tradicional China , Ecosistema , Placa Amiloide
2.
Front Neurosci ; 16: 1053283, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36590305

RESUMEN

Introduction: The second most prevalent cause of dementia is vascular dementia (VaD). Furthermore, acupuncture is a relatively safe and effective traditional therapy for individuals with VaD. We performed a network meta-analysis to assess the effectiveness and safety of various acupuncture therapies for VaD based on existing research. Methods: We searched six electronic databases to screen for randomized controlled trials (RCTs) comparing different acupuncture treatments in VaD patients. The Cochrne tool (Review Manager 5.3) was used to evaluate the risk of bias of the included RCTs. Based on the Grading of Recommendations Assessment, Development and Evaluation framework, we assessed the confidence in the evidence using the Confidence In the results from Network Meta-Analysis approach. We used the frequency approach to perform the network meta-analysis. Data were analyzed using R 4.1.1. Results: In total, we included 46 eligible studies. The results of the network analysis showed that the combined interventions of moxibustion (MB) with body acupuncture (BA) (MB + BA) and electroacupuncture (EA) with scalp acupuncture (SA) with BA (EA + SA + BA) were more effective in improving cognitive functions and activities of daily living compared with SA or BA alone. However, in the subgroup analysis, EA + SA + BA showed better efficacy in short- and mid-term acupuncture compared with other acupuncture therapies. Conclusion: Combined acupuncture therapy may be a safe and effective intervention for individuals with VaD, and MB + BA and EA + SA + BA appear to be the most effective interventions. However, because the analysis of this study was based on low-to-moderate evidence, there remains no strong supporting evidence. Thus, high-quality, large-scale, and long-term studies should be conducted in the future to assess the effectiveness and safety of acupuncture in VaD. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42022354573.

3.
Ecotoxicol Environ Saf ; 205: 111372, 2020 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-32977281

RESUMEN

The production of natural selenium (Se)-rich food by using a high-Se crop cultivar is beneficial to human health and environmental safety; however, the underlying mechanism of different Se-accumulation ability between high- and low-Se rice cultivars remains unclear. A low-grain-Se cultivar and high-grain-Se cultivar of rice were used as test materials, and two levels of Se (0 and 0.5 mg kg-1) were arranged in a randomized design containing twelve replicates. The dynamic changes of shoot Se concentration and accumulation, xylem sap Se concentration, shoot and grain Se distribution, Se transporters genes (OsPT2, Sultr1;2, NRT1.1B) expression of the high- and low-Se rice cultivars were determined. The shoot Se concentration and accumulation of the high-Se rice showed a greater degree of reduction than those of the low-Se rice during grain filling stage, indicating that leaves of high-Se rice served as a Se source and supplied more Se for the growth centre grain. The expression levels of OsPT2, NRT1.1B and Sultr1;2 in the high-Se rice cultivar were significantly higher than those in the low-Se rice cultivar, which indicated that the high-Se rice cultivar possessed better transport carriers. The distribution of Se in grain of the high-Se rice cultivar was more uniform, whereas the low-Se cultivar tended to accumulate Se in embryo end. The stronger reutilization of Se from shoots to grains promoted by increased transporters genes expression and optimized grain storage space may explain how the high-Se rice cultivar is able to accumulate more Se in grain.


Asunto(s)
Oryza/fisiología , Selenio/metabolismo , Cadmio/metabolismo , Grano Comestible/química , Humanos , Oryza/metabolismo , Contaminantes del Suelo/análisis , Xilema/metabolismo
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