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1.
Radiography (Lond) ; 30(3): 964-970, 2024 05.
Artículo en Inglés | MEDLINE | ID: mdl-38657390

RESUMEN

INTRODUCTION: Non-medical professionals in the United Kingdom (UK) have been granted prescribing rights to improve patient care quality and cost-effectiveness. There is limited evidence on how therapeutic radiographer prescribers have impacted medicine management or patient services. METHODS: An online survey was conducted amongst non-medical prescribing therapeutic radiographers in the UK between 2019 and 2022. The study teams initially analysed the individual data sets, subsequently combined, and secondary analysis was performed to provide a UK perspective, to understand the services provided and identify areas for improvement. Data was analysed using descriptive statistics from Microsoft Excel® and SPSS®. RESULTS: 74 non-medical prescribing therapeutic radiographers who were predominantly over 40 years old and in full-time work participated. The main job categories were consultant radiographers (n = 23, 31.1%) and advanced practice practitioners (n = 18, 24.3%). Many use their prescribing qualifications (87.5%, n = 62), issuing a mean of 15 independent and seven items by supplementary and prescribing per week. Most received assessment and diagnostic skills training before prescribing courses (91.6%, n = 67). Respondents prescribed from a median of six areas, with the highest being in GI (82%), skin (68%), infections (58%), urinary tract disorders (55%) and ear, nose, and oropharynx conditions (54%). CONCLUSION: This study presents the first report on therapeutic radiographers prescribing in the UK, offering insights into current practices and highlighting the success of non-medical prescribing. Therapeutic radiographers' roles continue to expand into advanced practice and medicine-prescribing responsibilities, contributing to holistic and patient-centred care. IMPLICATIONS FOR PRACTICE: The results are relevant for nations grappling with oncology workforce shortages and contemplating similar roles for therapeutic radiographers. The study can be a valuable resource for policymakers and healthcare organisations worldwide.


Asunto(s)
Radiografía , Humanos , Reino Unido , Encuestas y Cuestionarios , Femenino , Masculino , Adulto , Persona de Mediana Edad , Radiografía/estadística & datos numéricos , Prescripciones , Técnicos Medios en Salud
2.
Obes Rev ; 19(1): 14-27, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29024367

RESUMEN

The challenge of managing the epidemic of patients with severe and complex obesity disease in secondary care is largely unmet. In England, the National Institute of Health and Care Excellence and the National Health Service England have published guidance on the provision of specialist (non-surgical) weight management services. We have undertaken a systematic review of 'what evidence exists for what should happen in/commissioning of: primary or secondary care weight assessment and management clinics in patients needing specialist care for severe and complex obesity?' using an accredited methodology to produce a model for organization of multidisciplinary team clinics that could be developed in every healthcare system, as an update to a previous review. Additions to the previous guidance were multidisciplinary team pathways for children/adolescent patients and their transition to adult care, anaesthetic assessment and recommendations for ongoing shared care with general practitioners, as a chronic disease management pathway.


Asunto(s)
Peso Corporal , Manejo de la Enfermedad , Obesidad Mórbida/terapia , Obesidad Infantil/terapia , Adulto , Cirugía Bariátrica , Niño , Atención a la Salud/normas , Dieta , Inglaterra , Guías como Asunto , Humanos , Metaanálisis como Asunto , Programas Nacionales de Salud/normas , Ensayos Clínicos Controlados Aleatorios como Asunto
3.
Proc Nutr Soc ; 75(3): 405-14, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-27170501

RESUMEN

Clinical deficiency of the B-vitamin riboflavin (vitamin B2) is largely confined to developing countries; however accumulating evidence indicates that suboptimal riboflavin status is a widespread problem across the developed world. Few international data are available on riboflavin status as measured by the functional biomarker, erythrocyte glutathione reductase activation coefficient, considered to be the gold standard index. One important role of riboflavin in the form of flavin dinucleotide is as a co-factor for the folate-metabolising enzyme methylenetetrahydrofolate reductase (MTHFR). Homozygosity for the common C677T polymorphism in MTHFR, affecting over 10 % of the UK and Irish populations and up to 32 % of other populations worldwide, has been associated with an increased risk of CVD, and more recently with hypertension. This review will explore available studies reporting riboflavin status worldwide, the interaction of riboflavin with the MTHFR C677T polymorphism and the potential role of riboflavin in personalised nutrition. Evidence is accumulating for a novel role of riboflavin as an important modulator of blood pressure (BP) specifically in individuals with the MTHFR 677TT genotype, with results from a number of recent randomised controlled trials demonstrating that riboflavin supplementation can significantly reduce systolic BP by 5-13 mmHg in these genetically at risk adults. Studies are however required to investigate the BP-lowering effect of riboflavin in different populations and in response to doses higher than 1·6 mg/d. Furthermore, work focusing on the translation of this research to health professionals and patients is also required.


Asunto(s)
Presión Sanguínea/efectos de los fármacos , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Estado Nutricional , Riboflavina/sangre , Animales , Biomarcadores/sangre , Suplementos Dietéticos , Modelos Animales de Enfermedad , Relación Dosis-Respuesta a Droga , Ácido Fólico/administración & dosificación , Ácido Fólico/sangre , Genotipo , Homocigoto , Humanos , Irlanda , Necesidades Nutricionales , Polimorfismo de Nucleótido Simple , Ensayos Clínicos Controlados Aleatorios como Asunto , Deficiencia de Riboflavina/sangre , Deficiencia de Riboflavina/tratamiento farmacológico , Factores de Riesgo , Reino Unido
4.
Complement Ther Clin Pract ; 21(1): 19-25, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25544064

RESUMEN

INTRODUCTION: Advances in cancer diagnosis and treatment have resulted in longer survival, meaning patients are living with a chronic-type condition. Therefore the needs of such patients have changed placing greater emphasis on survivorship, such as impact on quality of life and sleep patterns. Evidence suggests complementary therapies positively impact not only on the cancer patient's quality of life but also on family members and friends. METHODOLOGY: This service evaluation examines self-reported benefits following a course of complementary therapy offered by a local cancer charity. RESULTS: Analysis of self-reported sleep scores and perceived quality of life experiences confirmed a number of trends relating to the demographics of people accessing the complementary therapy service. CONCLUSION: Results suggest the complementary therapies provided by Action Cancer significantly improved clients' quality of life. Based on these findings the authors make a number of recommendations in relation to the use of complementary therapies by cancer patients.


Asunto(s)
Terapias Complementarias/psicología , Terapias Complementarias/estadística & datos numéricos , Neoplasias/psicología , Neoplasias/terapia , Aceptación de la Atención de Salud , Femenino , Humanos , Masculino , Persona de Mediana Edad , Calidad de Vida
5.
Artículo en Inglés | MEDLINE | ID: mdl-24883067

RESUMEN

Background. Reflexology is one of the top forms of complementary and alternative medicine in the UK and is used for healthcare by a diverse range of people. However, it is offered by few healthcare providers as little scientific evidence is available explaining how it works or any health benefits it may confer. The aim of this review was to assess the current evidence available from reflexology randomised controlled trials (RCTs) that have investigated changes in physiological or biochemical outcomes. Methods. Guidelines from the Cochrane Handbook of Systematic Reviews of Interventions were followed: the following databases were searched from inception to December 2013: AMED, CAM Quest, CINAHL Plus, Cochrane Central Register of Controlled Trials, Embase, Medline Ovid, Proquest, and Pubmed. Risk of bias was assessed independently by two members of the review team and overall strength of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation guidelines. Results. Seventeen eligible RCTs met all inclusion criteria. A total of 34 objective outcome measures were analysed. Although twelve studies showed significant changes within the reflexology group, only three studies investigating blood pressure, cardiac index, and salivary amylase resulted in significant between group changes in favour of reflexology. The overall quality of the studies was low.

6.
Asian-Australas J Anim Sci ; 26(7): 1021-9, 2013 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-25049881

RESUMEN

To investigate the effect of dietary chromium (Cr) as Cr methionine (CrMet) on growth performance, carcass traits, pork quality, meat colour and expression of meat colour-related genes in growing-finishing pigs, 189 crossbred Duroc×(Landrace×Yorkshire) growing-finishing pigs (male, castrated, average initial BW 74.58±1.52 kg) were selected and randomly allocated into four groups. Dietary treatments per kg of feed were as follows: 0 (CT), 0.3 mg/kg (T1), 0.6 mg/kg (T2) and 0.9 mg/kg (T3) Cr (in the form of CrMet; as-fed basis), and each treatment was replicated five times with 8 to 10 pigs per replicate pen. During the 28 d of the experiment, both the ADG and the ADFI increased linearly (p<0.05) as the level of dietary Cr increased. The F/G ratio decreased linearly (p<0.05). As dietary Cr increased, loin muscle areas (linear, p = 0.013) and average backfat thickness (linear, p = 0.072) decreased. Shear force (linear, p = 0.070) and Commission Internationale de I'Éclairage (CIE) redness (quadratic, p = 0.028) were increased. In addition, CIE Lightness (quadratic, p = 0.053) were decreased as dietary Cr increased. As dietary Cr increased, total myglobin (Mb) content (quadratic, p = 0.015) and the mb mRNA levels (quadratic, p = 0.046) in longissimus muscles of pigs were up-regulated. In conclusion, supplementation of dietary Cr improved growth and meat colour, but increased shear force and decreased IMF reduced palatability of longissimus muscles. Moreover, the increasing total Mb content and mb mRNA levels indicated that CrMet dietary supplementation may improve meat colour via up-regulating expression of the mb gene.

7.
Altern Ther Health Med ; 17(3): 32-7, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-22164810

RESUMEN

BACKGROUND: Reflexology has been shown to reduce anxiety and stress in various populations. The mechanism by which this occurs may be in modulating autonomic nervous system (ANS) function; however; there is limited evidence available in the area. PRIMARY STUDY OBJECTIVE: The aim of the study was to investigate the feasibility of using an experimental model to determine the physiological effect of reflexology on stress. METHODS/DESIGN: A feasibility study to assess an experimental study design to compare the effect of reflexology and control interventions on heart rate (HR) and blood pressure (BP) following mental stress tests. SETTING: The Health and Rehabilitation Science Research Institute at the University ofUlster, Northern Ireland, United Kingdom. PARTICIPANTS: Twenty-six healthy volunteers. INTERVENTION: Mental stress was induced before and after intervention. Participants in the reflexology group received 20 minutes of reflexology, and the control group received 20 minutes of relaxation with a therapist holding each participant's feet. PRIMARY OUTCOME MEASURES: The outcome measures, HR and BP, were measured throughout mental stress testing intervention, and a second period of mental stress testing following intervention. RESULTS: The study design was considered feasible. There were significant reductions in systolic blood pressure (SBP) (22%; P = .03) and in diastolic blood pressure (DBP) (26%; P = .01) during mental stress following reflexology compared to the stress period prior to intervention. In contrast, there was a 10% reduction in SBP (P = .03) but a 5% increase in DBP (P = .67) during the period of mental stress following the control intervention compared to results obtained during mental stress prior to this intervention. However, there were no significant differences between reflexology and control groups. CONCLUSION: This study has demonstrated the feasibility of conducting an experimental study on the effect ofreflexology in stress using BP as the primary outcome measure. Results from such a study would address the lack of high-quality evidence for the physiological effects of reflexology.


Asunto(s)
Ansiedad/prevención & control , Sistema Nervioso Autónomo/fisiología , Estado de Salud , Masaje/métodos , Adulto , Ansiedad/psicología , Biometría , Presión Sanguínea , Estudios de Factibilidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Irlanda del Norte , Psicometría , Valores de Referencia , Resultado del Tratamiento , Reino Unido , Adulto Joven
8.
Complement Ther Med ; 19(3): 149-54, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21641520

RESUMEN

BACKGROUND AND PURPOSE: The aim of this survey was to investigate complementary and alternative medicine (CAM) use by physiotherapists for the treatment of low back pain (LBP). METHODS: Questionnaires (n=1000) were distributed to physiotherapists randomly selected from the UK's Organisation of Chartered Physiotherapists in Private Practice (OCPPP). Results were analysed by SPSS. RESULTS: A response rate of 46% was obtained (n=459). 94.3% of respondents stated that they currently treated LBP; the most common CAMs used by physiotherapists were acupuncture (46.9%) and massage (2.1%). Physiotherapists perceived acupuncture, massage, osteopathy, chiropractic and yoga to be effective in the treatment of LBP, but were unsure about the effectiveness of other CAMs. DISCUSSION AND CONCLUSION: Physiotherapists in this sample often use acupuncture and massage to treat LBP, but appear to have little knowledge of other CAMs. Physiotherapists use mainstream methods such as mobilization and massage which could be perceived as CAM depending on the physiotherapists' perceptions and training, as these therapies have also been used and investigated by CAM practitioners. More research is required on the use of CAM as little is known regarding the effectiveness of these therapies on LBP.


Asunto(s)
Terapias Complementarias/estadística & datos numéricos , Dolor de la Región Lumbar/terapia , Fisioterapeutas , Terapia por Acupuntura , Humanos , Manipulaciones Musculoesqueléticas , Encuestas y Cuestionarios , Reino Unido , Yoga
9.
Artículo en Inglés | MEDLINE | ID: mdl-20189789

RESUMEN

Musculoskeletal complaints are the second most frequent reason for medical treatments. Within these diseases rheumatoid arthritis (RA) and, especially, osteoarthritis (OA) are common. Although the causes of arthritis are multifactorial and not fully understood, clinical trials have generally shown benefit from dietary n-3 polyunsaturated fatty acids. This has usually been attributed to their anti-inflammatory properties. Recently we have used in vitro model systems to study the molecular mechanism(s) by which n-3 PUFAs may act to alleviate the symptoms of arthritis. These experiments showed that n-3 PUFAs reduce expression of cartilage-degrading proteinases, cyclooxygenase-2 and inflammatory cytokines. Eicosapentaenoic acid (EPA) was more effective than docosahexaenoic acid (DHA) or alpha-linolenic acid. The data provide a scientific rationale for the consumption of n-3 fatty acids as part of a healthy diet and perhaps in treating arthritis.


Asunto(s)
Artritis/tratamiento farmacológico , Ácidos Docosahexaenoicos/uso terapéutico , Ácido Eicosapentaenoico/uso terapéutico , Ácido alfa-Linolénico/uso terapéutico , Animales , Artritis/metabolismo , Artritis Reumatoide/tratamiento farmacológico , Artritis Reumatoide/metabolismo , Ensayos Clínicos como Asunto , Ciclooxigenasa 2/metabolismo , Citocinas/metabolismo , Grasas de la Dieta/administración & dosificación , Ácidos Docosahexaenoicos/administración & dosificación , Ácido Eicosapentaenoico/administración & dosificación , Humanos , Metaloproteinasas de la Matriz/metabolismo , Osteoartritis/tratamiento farmacológico , Osteoartritis/metabolismo , Resultado del Tratamiento , Ácido alfa-Linolénico/administración & dosificación
10.
Mult Scler ; 15(11): 1329-38, 2009 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19825891

RESUMEN

Multiple sclerosis (MS) results in pain and other symptoms which may be modified by conventional treatment, however, MS is still not curable. Several studies have reported positive effects of reflexology in the treatment of pain, however, no randomised controlled clinical trials for the treatment of pain have been conducted within this population. The objective of this study was to investigate the effectiveness of reflexology on pain in and MS population. We randomly allocated 73 participants to receive either precision or sham reflexology weekly for 10 weeks. Outcome measures were taken pre-and post-treatment with follow-up at 6 and 12 weeks by a researcher blinded to group allocation. The primary outcome measure recorded pain using a Visual Analogue Scale (VAS). A significant (p < 0.0001) and clinically important decrease in pain intensity was observed in both groups compared with baseline. Median VAS scores were reduced by 50% following treatment, and maintained for up to 12 weeks. Significant decreases were also observed for fatigue, depression, disability, spasm and quality of life. In conclusion, precision reflexology was not superior to sham, however, both treatments offer clinically significant improvements for MS symptoms via a possible placebo effect or stimulation of reflex points in the feet using non-specific massage.


Asunto(s)
Masaje , Esclerosis Múltiple/complicaciones , Manejo del Dolor , Adulto , Anciano , Depresión/etiología , Depresión/psicología , Evaluación de la Discapacidad , Método Doble Ciego , Fatiga/etiología , Fatiga/prevención & control , Femenino , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/psicología , Dolor/etiología , Dolor/psicología , Dimensión del Dolor , Calidad de Vida , Resultado del Tratamiento
11.
Osteoarthritis Cartilage ; 17(7): 896-905, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19217322

RESUMEN

OBJECTIVE: To assess the relative efficacy of three different omega-3 (n-3) polyunsaturated fatty acids (PUFAs) in suppressing the mRNA levels for important proteins involved in the etiology of osteoarthritis (OA). METHODS: A model cell culture system (bovine chondrocytes) was used. Inflammatory factors and enzymes involved in OA were induced by exposure of the chondrocyte cultures to interleukin-1alpha (IL-1alpha). The effect of pre-incubating cultures with various amounts of exogenous fatty acids on subsequent levels of mRNAs was assessed by reverse transcription-polymerase chain reactions (RT-PCR). RESULTS: Exposure of cultures to IL-1alpha induced expression of the cartilage proteinases A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS)-4 and ADAMTS-5, cyclooxygenase (COX)-2, the matrix metalloproteinase (MMP)-3 and the inflammatory cytokines IL-1alpha, interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha). n-3 PUFAs were able to reduce the levels of mRNA for ADAMTS-4, ADAMTS-5, MMP-3, MMP-13, COX-2 (but not COX-1), IL-1alpha, IL-1beta and TNF-alpha. Eicosapentaenoic acid (EPA) was the most effective, followed by docosahexaenoic (DHA) and then alpha-linolenic (ALA) acid. The n-6 PUFA, arachidonic acid (AA) had no effect. CONCLUSION: These results show that omega-3 (n-3) PUFAs cause a reduction in the mRNA levels for various proteins known to be important in the pathology of OA. They provide a molecular explanation, at least in part, for beneficial effects of dietary omega-3 PUFAs for the amelioration of symptoms of the disease. The relative efficacy of EPA suggests that this omega-3 PUFA may be especially useful for dietary supplementation in patients with OA.


Asunto(s)
Condrocitos/metabolismo , Ácidos Grasos Omega-3/farmacología , Osteoartritis/metabolismo , Péptido Hidrolasas/metabolismo , Proteínas ADAM/metabolismo , Animales , Carpo Animal , Cartílago Articular/metabolismo , Bovinos , Células Cultivadas , Ciclooxigenasa 2/metabolismo , Citocinas/metabolismo , Modelos Animales de Enfermedad , Interleucina-1alfa/farmacología , Ácido Láctico/biosíntesis , Metaloproteinasas de la Matriz/metabolismo , Osteoartritis/etiología , Osteoartritis/prevención & control , ARN Mensajero/metabolismo
12.
Complement Ther Med ; 16(1): 3-8, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-18346622

RESUMEN

OBJECTIVE: The current study was designed as a pilot study for a randomised controlled trial to investigate the effectiveness of reflexology in the management of low back pain (LBP). MATERIALS AND METHODS: Participants suffering non-specific LBP were recruited and randomised into either a reflexology or a sham group. Patients and outcome assessor were blinded to group allocation. Each patient received either a 40 min reflexology treatment or sham treatment (according to group allocation) once per week for six consecutive weeks. The primary outcome measure was pain (visual analogue scale), secondary outcome measures were the McGill pain questionnaire, Roland-Morris disability questionnaire, and SF-36 health survey. Outcome measures were performed at baseline, week 6, week 12 and week 18. RESULTS: VAS scores for pain reduced in the treatment group by a median value of 2.5 cm, with minimal change in the sham group (0.2 cm). Secondary outcome measures produced an improvement in both groups (McGill pain questionnaire: 18 points in the reflexology group and 11.5 points in the sham group). Results indicate that reflexology may have a positive effect on LBP. CONCLUSION: Reflexology appears to offer promise as a treatment in the management of LBP; however, an adequately powered trial is required before any more definitive pronouncements are possible.


Asunto(s)
Dolor de la Región Lumbar/terapia , Masaje , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Proyectos Piloto
13.
Complement Ther Med ; 16(1): 9-14, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-18346623

RESUMEN

OBJECTIVE: To investigate current management of low back pain (LBP) by reflexologists. METHODS: A postal survey of reflexologists (n=500) sampled from the International Institute of Reflexology. The questionnaire used investigated a range of areas including: professional details, reflexology training and practice, views and experiences of reflexology, reflexology and LBP, and views on other complementary therapies. RESULTS: Response rate was 49.6% (n=248). The majority of respondents were female (95%), and were primarily employed within another profession such as nursing or teaching. Respondents perceived reflexology to have a positive effect on relieving LBP (94.3%) and to provide more benefit than simply relaxation. Practitioners also commented on other treatment effects, e.g. improving sleep patterns, decreasing anxiety and stress. It was reported that other healthcare practitioners, including general practitioners, referred patients to reflexologists for treatment. DISCUSSION: Respondents considered reflexology to be an effective therapy for LBP. Further work is warranted to investigate the potential role of such treatment in the management of this prevalent and intractable condition.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Dolor de la Región Lumbar/terapia , Masaje , Adulto , Ansiedad/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trastornos del Sueño-Vigilia/terapia , Estrés Psicológico/terapia , Encuestas y Cuestionarios
14.
Int J Sport Nutr Exerc Metab ; 15(5): 480-92, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16327031

RESUMEN

The purpose of this investigation was to determine the effects of antioxidant supplementation on DNA damage following exercise. Fourteen subjects were randomly assigned to one of two groups and required to ingest either antioxidants (400 mg alpha-lipoic acid, 200 mg co-enzyme Q10, 12 mg manganese, 600 mg vitamin C, 800 mg N-acetyl cysteine, 400 microg selenium, and 400 IU alpha-tocopherol per day) or placebos for 7 d. Exercise increased DNA damage, PS, FRAP, and LDH (P < 0.05), but not selectively between groups. LDH and PS concentration decreased 1 h post-exercise (P < 0.05), while LH concentration decreased 1 h post-exercise in the antioxidant group only (P < 0.05). The antioxidant group had a higher concentration of LH (P < 0.05), perhaps due to a selective difference between groups post-exercise (P < 0.05). The main findings of this investigation demonstrate that exhaustive aerobic exercise induces DNA damage, while antioxidant supplementation does not protect against damage.


Asunto(s)
Antioxidantes/farmacología , Daño del ADN/efectos de los fármacos , Ejercicio Físico/fisiología , Leucocitos Mononucleares/efectos de los fármacos , Estrés Oxidativo/efectos de los fármacos , Adulto , Antioxidantes/administración & dosificación , Ensayo Cometa , Suplementos Dietéticos , Método Doble Ciego , Hematócrito , Hemoglobinas/análisis , Humanos , L-Lactato Deshidrogenasa/metabolismo , Leucocitos Mononucleares/fisiología , Peroxidación de Lípido/efectos de los fármacos , Peroxidación de Lípido/fisiología , Masculino , Estrés Oxidativo/fisiología
15.
J Clin Pharm Ther ; 30(1): 39-44, 2005 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-15659002

RESUMEN

BACKGROUND AND OBJECTIVES: One major concern associated with misuse/abuse of over-the-counter (OTC) products is the potential for over-dosage. The aim of this research study was to evaluate, over a 3-month period, OTC medicine-related overdoses (those involving OTC drugs only and OTC drugs in combination with other drugs) that led to patients presenting at the Accident and Emergency (A & E) departments in four Belfast hospitals. METHODS: A data collection sheet was designed to capture the information required from the A & E records in each hospital. A retrospective week-by-week data collection, reviewing A & E records, took place over a 3-month period (starting on 1 December 2002). All data related to cases presenting at the A & E departments because of drug overdoses (either accidental or deliberate according to Read Clinical Classification) were included in the study. Data were coded and entered into a custom designed SPSS database for analysis, using Chi square and Fisher exact tests. RESULTS: OTC drug-related overdoses comprised 40.1% of all overdoses, of which 24.0% were OTC-only overdoses. Those who overdosed on OTC drugs (solely or combined with other drugs) were mainly female (62.3%) and in the age category 31-50 years (44.9%; P <0.05). The majority (n=215) of OTC-related overdoses were intentional, whereas only 28 were accidental. Of those who attended the A & E departments and had an overdose history, one-third overdosed on OTC-related products and two-thirds overdosed on OTC drugs only. CONCLUSIONS: OTC drugs accounted for a significant proportion of overdose presentations at the A & E departments in Northern Ireland. Higher awareness of the potential of OTC product use in overdose cases (intentional or accidental) is recommended for both the public and health care professionals.


Asunto(s)
Sobredosis de Droga/epidemiología , Sobredosis de Droga/etiología , Servicios Médicos de Urgencia/estadística & datos numéricos , Medicamentos sin Prescripción/efectos adversos , Estudios Retrospectivos , Acetaminofén/efectos adversos , Factores de Edad , Consumo de Bebidas Alcohólicas/efectos adversos , Aspirina/efectos adversos , Recolección de Datos/métodos , Bases de Datos como Asunto , Combinación de Medicamentos , Incompatibilidad de Medicamentos , Interacciones Farmacológicas , Prescripciones de Medicamentos/clasificación , Urgencias Médicas/epidemiología , Femenino , Humanos , Ibuprofeno/efectos adversos , Masculino , Medicamentos sin Prescripción/administración & dosificación , Irlanda del Norte/epidemiología , Autoadministración/métodos , Autoadministración/estadística & datos numéricos , Clase Social , Factores de Tiempo
16.
Pharm World Sci ; 23(5): 195-9, 2001 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11721678

RESUMEN

AIM OF THE STUDY: To gain more detailed information on the current pharmaceutical service provision in nursing and residential homes in Northern Ireland and to assess the views of care staff on future pharmacy services. METHOD: A structured questionnaire was developed and mailed to all nursing and residential homes (n = 586) in Northern Ireland on two occasions. RESULTS: A response rate of 68% (n = 396) was obtained. The most frequent services currently provided by community pharmacists were the supply of medication and the collection of unwanted, discontinued or out-of-date medicines. The majority of respondents also reported receiving advice on safe-keeping, correct administration of medicines, advice on more appropriate formulations and advice on patient medication records from the community pharmacist. Over a third of all the respondents received advice on compliance devices. A similar proportion stated that their care staff were trained by the pharmacist on broad medication management issues. Over 90% of all homes strongly supported staff training by pharmacists on the recognition of medication-related problems as a future service. Over 70% of all respondents thought additional guidelines and advice for missed dosages and the use of home remedies would be beneficial. A review of patient medication records to assess drug-drug interactions and possible adverse drug reactions by pharmacists was supported by over 65% of all respondents. CONCLUSIONS: This work has demonstrated that those responsible for care in nursing and residential facilities strongly support further involvement by the pharmacist in these care facilities; pharmacy policy makers must ensure that such services are developed to meet the needs of these vulnerable elderly residents.


Asunto(s)
Anciano/estadística & datos numéricos , Servicios Comunitarios de Farmacia/estadística & datos numéricos , Hogares para Ancianos/estadística & datos numéricos , Casas de Salud/estadística & datos numéricos , Farmacéuticos/estadística & datos numéricos , Humanos , Irlanda del Norte , Instituciones Residenciales/métodos , Instituciones Residenciales/estadística & datos numéricos , Encuestas y Cuestionarios
17.
Menopause ; 8(5): 338-46, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11528360

RESUMEN

OBJECTIVE: To assess the effects of a red clover-derived isoflavone extract on the Ki-67 proliferative marker of endometrial biopsies in 45-to 50-year-old perimenopausal women. We hypothesized that we would be able to detect a decrease in the Ki-67 proliferative index during the late follicular phase after a 3-month course of approximately 50 mg red clover isoflavones. Isoflavones have been found to have some antiestrogenic effects, and an antiproliferative effect during the perimenopausal period may be especially useful owing to the excessive endometrial proliferation often characteristic of this period. DESIGN: In a double-blind, randomized, controlled study, 30 women between the ages of 45 and 50 years consented to an endometrial biopsy before and after a 3-month course of either placebo or active isoflavone extract. The biopsies were timed as close as possible to days 7-11 of the menstrual cycle, and simultaneous measurements of transvaginal endometrial thickness, uterine artery Doppler, hormone profiles, lipids, and bone markers were performed. RESULTS: Of 30 women, 2 did not return for a second biopsy, and a third had an unsuccessful second biopsy. Four subjects were excluded from the Intention to Treat analysis because they did not have a menstrual bleed within the time frame of the study (3 subjects) or were tested on day 13 instead of between days 7 and 11 of the cycle (1 subject). There was no change in the Ki-67 proliferation index after treatment in either group. Eight subjects in the placebo group and eight in the P-07 group had proliferative endometrial biopsies that were synchronized with estradiol levels at baseline and post-treatment, and analysis of these subjects revealed no detectable change in the relationship between estradiol levels and Ki-67 with treatment in either group. There was no change in fasting lipids, bone markers, uterine Doppler resistance, or pulsatility index. CONCLUSION: In this small pilot study, we did not find, using immunohistochemical quantification of the Ki-67 antigen, that red clover isoflavones had an antiproliferative effect in the endometrium. Small sample size, examination of a relatively short interval in the menstrual cycle, and isoflavone formulation may have contributed to our lack of findings; however, we believe that the issue of isoflavones and their possible antiproliferative effect is deserving of further study. A simpler physiological model with less hormonal variability, such as healthy, recently menopausal women on predetermined doses of estrogen, may prove to be more informative.


Asunto(s)
Endometrio/efectos de los fármacos , Isoflavonas/farmacología , Plantas Medicinales , División Celular , Método Doble Ciego , Neoplasias Endometriales/prevención & control , Femenino , Fase Folicular/fisiología , Humanos , Inmunohistoquímica , Isoflavonas/uso terapéutico , Antígeno Ki-67/metabolismo , Persona de Mediana Edad , Proyectos Piloto , Ultrasonografía Doppler , Útero/diagnóstico por imagen
18.
Midwifery ; 17(1): 55-64, 2001 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11207105

RESUMEN

OBJECTIVES: to examine the instruction in pelvic floor exercises given to women during pregnancy or following delivery, to assess the quality of any instruction provided, and to consider these in light of the women's views about the service. DESIGN: a postal questionnaire was sent to a sample of women when they reached 34 weeks of pregnancy and a second at 8 weeks postpartum. A sub-sample of women who reported symptoms of stress incontinence at 8 weeks postpartum were interviewed about the instruction in pelvic floor exercises that they received during their pregnancy, or in the puerperium. PARTICIPANTS: of the 918 women who were sent the first questionnaire, 717 returned it completed (78%). Five-hundred-and-seventy-two of 894 women (64%) completed the second questionnaire. Forty-two of 179 symptomatic women (23%) took part in an interview. FINDINGS: 55% of women received some form of instruction in pelvic floor exercises by 34 weeks of pregnancy. Eighty-six percent received instruction following birth. The way the information was given varied, ranging from a brief reminder, to exercising in a class with an instructor. The information was provided by a range of health professionals, and no single profession appeared to undertake responsibility for the service. As a result, the views of the service varied. A few women reported that they had received good quality instruction, others were critical of it, and a small number reported that they had received no instruction at all. The widespread practice of leaving a leaflet by the women's beds during their stay in hospital, was criticised by a large proportion of the women. KEY CONCLUSION: the instruction in pelvic floor exercises by health service professionals was provided on an ad hoc basis. In many instances, the programme of instruction did not meet recommendations made in the literature. It is likely that the success of randomised controlled trials reported in the literature would not be repeated in the 'real world' Implications for practice: there is a need for the service to be reorganised so that all women receive high-quality instruction during pregnancy, with a reminder to exercise following birth. This could help to prevent, or relieve, the symptoms of stress incontinence that frequently occur at these times.


Asunto(s)
Terapia por Ejercicio/métodos , Madres/psicología , Diafragma Pélvico/fisiopatología , Incontinencia Urinaria de Esfuerzo/terapia , Adulto , Inglaterra , Femenino , Humanos , Recién Nacido , Persona de Mediana Edad , Partería/normas , Evaluación en Enfermería/normas , Investigación Metodológica en Enfermería , Educación del Paciente como Asunto/normas , Periodo Posparto , Embarazo , Complicaciones del Embarazo/psicología , Complicaciones del Embarazo/terapia , Relaciones Profesional-Paciente , Encuestas y Cuestionarios , Incontinencia Urinaria de Esfuerzo/psicología
19.
J Tissue Viability ; 11(2): 56-8, 2001 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11949374

RESUMEN

Anecdotal evidence suggests that there is an increase in the incidence of pressure damage to women in labour. This appears to be associated with epidural anaesthesia. Epidural anaesthesia used to control pain in childbirth causes loss of sensation and a degree of motor block, which removes the women's reflexes and ability to reposition to prevent pressure damage. The large amount of fluids present during childbirth may also increase the risk of pressure damage, especially in association with shear and friction. A combination of unfamiliarity of pressure ulcer prevention techniques among midwives, and the type of delivery room equipment, that is currently available, may leave young healthy women at risk of developing pressure ulcers.


Asunto(s)
Anestesia Epidural/efectos adversos , Parto Obstétrico , Úlcera por Presión/etiología , Adulto , Femenino , Humanos , Trabajo de Parto , Partería , Embarazo , Úlcera por Presión/enfermería , Úlcera por Presión/prevención & control , Factores de Riesgo
20.
Pac Health Dialog ; 8(2): 393-400, 2001 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-12180521

RESUMEN

The Uli'eo Koa Program was developed to study physiological and spiritual changes that occurred in a group of active Native Hawaiian adults participating in a specially designed, culturally appropriate exercise and diet intervention that approximated the training for Native Hawaiian warriors. Program components were physical exercise (including traditional Hawaiian lua [fighting art]), a traditional Hawaiian diet (THD), lomilomi (Hawaiian massage), and a culturally rich health education program for active Native Hawaiian adults. Periodic assessments of muscle strength/fitness, flexibility, body composition, weight, body mass index, as well as other indicators, were compared to current standards of clinical medicine and science related to physical performance. Differences observed from baseline to post-intervention suggested that the Uli'eo Koa Program may be effective in improving the health of Native Hawaiians. Limitations and clinical implications of the study are discussed.


Asunto(s)
Etnicidad , Promoción de la Salud/métodos , Salud Holística , Aptitud Física/fisiología , Adulto , Índice de Masa Corporal , Características Culturales , Dieta , Ejercicio Físico/fisiología , Hawaii/epidemiología , Educación en Salud/métodos , Humanos , Educación y Entrenamiento Físico , Aptitud Física/psicología , Evaluación de Programas y Proyectos de Salud , Espiritualidad
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