RESUMEN
Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (1, 2, 4-8), along with known polyketides (3, 9-13). Structures of compounds 1, 2, and 4-8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum.
Asunto(s)
Policétidos , Xylariales , Policétidos/química , Terpenos/química , Estructura Molecular , Extractos VegetalesRESUMEN
Covering: up to 2013. Natural products isolated from microorganisms from Brazil are comprehensively reviewed, including the microbial sources, bioactivities and biosynthesis. Analysis of trends related to the research on microbial natural products in Brazil is discussed in detail. An outlook to future perspectives of research in Brazil is presented considering the development of state-of-the-art strategies and approaches that have emerged during the last decade, aiming to investigate and better understand the microbial world and its chemical and biochemical capabilities. Finally, the importance of microbial natural products biodiscovery is discussed in the context of the BIOTA-FAPESP program in Brazil.