Asunto(s)
Cicatriz/fisiopatología , Procedimiento de Fontan , Taquicardia Reciprocante/fisiopatología , Atresia Tricúspide/cirugía , Válvula Tricúspide/fisiopatología , Vena Cava Inferior/fisiopatología , Ablación por Catéter , Técnicas Electrofisiológicas Cardíacas , Femenino , Humanos , Persona de Mediana Edad , Taquicardia Reciprocante/cirugíaAsunto(s)
Cateterismo Cardíaco/instrumentación , Anomalía de Ebstein/cirugía , Atrios Cardíacos/fisiopatología , Frecuencia Cardíaca , Implantación de Prótesis de Válvulas Cardíacas/instrumentación , Prótesis Valvulares Cardíacas , Taquicardia Supraventricular/etiología , Válvula Tricúspide/cirugía , Potenciales de Acción , Cateterismo Cardíaco/efectos adversos , Ablación por Catéter , Anomalía de Ebstein/fisiopatología , Técnicas Electrofisiológicas Cardíacas , Femenino , Atrios Cardíacos/cirugía , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Humanos , Persona de Mediana Edad , Taquicardia Supraventricular/diagnóstico , Taquicardia Supraventricular/fisiopatología , Taquicardia Supraventricular/cirugía , Resultado del Tratamiento , Válvula Tricúspide/anomalías , Válvula Tricúspide/fisiopatologíaRESUMEN
BACKGROUND: Monomorphic ventricular tachycardia (MVT) is common in adults with repaired tetralogy of Fallot (TOF), and is associated with sudden cardiac death. Management of MVT is not defined, and results of catheter ablation (CA) are limited. AIMS: To evaluate long-term outcomes of MVT CA in repaired TOF. METHODS: Thirty-four patients (mean age 32±10.3 years; 59% male) with repaired TOF underwent CA for symptomatic MVT between 1990 and 2012 in our centre; direct-current ablation (DCA) was used in 6%, radiofrequency followed by DCA in 29% and radiofrequency alone in 65%. RESULTS: Right ventricular (RV) dysfunction was present in 35% and left ventricular (LV) dysfunction in 21%. Mean numbers of clinical and induced MVTs were 1 and 2, respectively. Mean VT rate was 225±95bpm. Ablation targeted a single site (range 1-2), which was RV outflow tract in 85%. Primary success, defined as ventricular tachycardia (VT) termination during CA and final non-inducibility, was obtained in 82%. Seven patients (21%) required redo ablation in the first 3 months (before 2004; DCA). No death related to CA occurred. Mean follow-up time was 9.5±5.2 years. Antiarrhythmic therapy was discontinued in 71%. There were two cases of sudden cardiac death and four VT recurrences. Freedom from death and arrhythmia recurrence was 94% at 5 years, 81% at 10 years and 70% at 20 years. Global survival was 91% at 20 years. Baseline LV ejection fraction<60% was significantly associated with ventricular arrhythmia recurrence (hazard ratio 16.4, 95% confidence interval 1.8-147; P=0.01). CONCLUSIONS: CA can safely address macroreentrant MVT in repaired TOF patients with an acceptable long-term rate of recurrence in this high-risk population. Anatomical classification of isthmuses with electroanatomical mapping provides reproducible endpoints for CA. Attention should be given to LV systolic function in risk assessment and selection of candidates for implantable cardioverter-defibrillator.