Effects of static stretching and strengthening exercises on flexion relaxation ratio in patients with LBP: A randomized clinical trial.

INTRODUCTION: Stretching and strengthening exercises are commonly used to improve muscle shortness. Consequently, the aim of this trial was to compare the flexion-relaxation response (electromyography activities of shortened hamstring and back muscles) in chronic nonspecific LBP patients. METHODS: In this randomized controlled clinical trial, forty-five eligible patients were randomly categorized into three groups; static stretching (n = 15), strengthening exercise in lengthened hamstring position (n = 15) and control (n = 15). All groups received conventional physical therapy for LBP and the two intervention groups received special exercise programs as well. Each group performed three treatment sessions for a week, a total of 12 sessions. The flexion-relaxation ratio (FRR) for knee and back muscles were assessed as the primary outcome measure. Pain and functional disability for participants were also assessed. RESULTS: The results indicated non-significant differences between the three groups regarding the changes of FRR (mean between-group differences ranged over 0.69 to 39.1; p > 0.05), pain and disability (mean between-group differences ranged over 0.15 to 5.96; p > 0.05). Within-group analysis for each group, revealed statistically significant improvement in the patients' score of either pain (mean within-group differences ranged over -27.20 to -35.76; p < 0.001) or disability (mean within-group differences ranged over -16.17 to 24.95; p < 0.001) as secondary outcomes. In other words, the scores of pain and disability decreased in all treatment groups as compared to the baseline. CONCLUSION: Neither static stretching nor strengthening exercises in lengthened hamstring position affected FRR more than the control group.

The effect of omega-3 fatty acid supplementation on seizure frequency in individuals with epilepsy: a systematic review and meta-analysis.

BACKGROUND: Although there is ample evidence for the effect of omega-3 supplementation on seizure frequency in individuals with epilepsy, the results are inconsistent. Therefore, we conducted this systematic review and meta-analysis to elucidate the potential effect of omega-3 supplementation in the adult and pediatric population. METHODS: Clinical trials articles were searched in electronic databases (Web of Science, Scopus, PubMed/Medline, Embase, and Google Scholar database up to October 2020). No language limitation was imposed in the literature search. Moreover, gray literature search was done via searching the references of identified review papers to find more potentially relevant articles. RESULTS: In order, the duration of the intervention and dosage of omega-3 fatty acid supplement of the included studies ranged from 12 to 42 weeks and 1000-2880 mg/day. Pooled results from the random-effects model indicated that seizure frequency following supplementation of omega-3 fatty acid decreased significantly (WMD: -6.15, 95% CI: -7.78, -4.53, P < 0.001). Furthermore, the results of the subgroup analysis revealed that seizure frequency was more alleviated in studies that used a daily dose of 1500 mg or less of omega-3 fatty acids as well as studies that had an intervention duration of more than 16 weeks. More importantly, our findings also showed that the effect of omega-3 intervention was greater in adults than in children with epilepsy. CONCLUSION: The current meta-analysis on available trials suggested that omega-3 supplementation resulted in beneficial effects on seizure frequency in adult and children with epilepsy.

Psychometric properties of the Persian version of the brief illness questionnaire in Iranian with non-specific chronic neck pain.

INTRODUCTION: The Brief Illness Perception Questionnaire (BIPQ) is an instrument for assessing the illness perception. Illness perception varies between individuals based on their health status. There is no study that assess the psychometric properties of the Persian version of BIPQ in neck pain patients. The goal of this study was to evaluate the reliability, construct validity, and exploratory factor analysis of the Persian BIPQ in individuals with non-specific chronic neck pain. METHODS: This is a cross-sectional study in which 123 individuals with non-specific chronic neck pain participated. 60 participants examined after 7 days for testing reliability. Reliability was assessed by intra-class correlation coefficient, standard error of measurement, and minimal detectable change. For assessing construct validity and item-total correlation, correlation tests were used. Also, exploratory factor analysis was done to assess the factor structure of the BIPQ. RESULTS: Exploratory factor analysis' results showed that there were 2 factors with Eigenvalues >1. Factor 1 included "identity", "consequence", "timeline", and "emotional response". Factor 2 consisted of "coherence" and "treatment control". The intra-class correlation coefficient and the cronbach's alpha for the total score was 0.8 and 0.86 respectively. Results of correlation tests showed an acceptable construct validity except with SF-12 mental component. Item-total correlation tests demonstrated that the correlations were above 0.3 for all subscales except for "treatment control" and "coherence". CONCLUSION: BIPQ has an acceptable properties to assess illness perception in individuals with non-specific chronic neck pain. The results of exploratory factor analysis and item-total correlation confirmed that 2-subscale version is more acceptable.

Test-retest reliability and responsiveness of isokinetic dynamometry to assess wrist flexor muscle spasticity in subacute post-stroke hemiparesis.

INTRODUCTION: To overcome the limitations of clinical scales, objective measurement methods are becoming prominent in spasticity assessment. The aim of this study was to assess the test-retest reliability and responsiveness of isokinetic dynamometry to evaluate wrist flexor spasticity in patients with subacute stroke. METHODS: Twenty six patients with hemiparetic stroke (13 men, 13 women, mean age 51.38 ± 12.64 years) volunteered to take part in this study. Resistive torque in the wrist flexor muscles was measured twice, 1 day apart, with an isokinetic dynamometer. Wrist extension was tested at four speeds (5, 60, 120 and 180°/s). Torque response at the lowest speed (5°/s) was attributed to the non-neural component of the wrist flexor muscles, and was subtracted from the torque response at the higher speeds to calculate reflex torque (spasticity). The reliability of reflex torque measurements at 60, 120 and 180°/s was evaluated with the intraclass correlation coefficient (ICC2,1) and standard error of measurement (SEM and SEM%), which reflect reproducibility and measurement error, respectively. Responsiveness was calculated as the smallest real difference (SRD and SRD%). RESULTS: Reproducibility was excellent at different movement speeds (ICC2, 1 0.76-0.85). SEM% ranged from 11% to 21%, and SRD% ranged from 30% to 58%. ICC values increased, and SEM% and SRD% decreased, as test speed increased. CONCLUSION: Our results support the reliability and responsiveness of isokinetic dynamometry to quantify spasticity in wrist flexor muscles in patients with subacute stroke. Reliability and responsiveness increased as the speed of wrist movement increased.

Effect of one session of tDCS on the severity of pain in women with chronic pelvic pain.

AIM: The present study aimed to investigate the effects of tDCS on pain score in women with Chronic Pelvic Pain (CPP). MATERIALS & METHODS: A total of 16 women with CPP participated in the present double-blind sham-controlled cross-over study. Each participant received a 20-min 0.3 MA of trans Cranial Direct Stimulation (tDCS) with a current density of 0.1 mA/cm2. In addition to the pain intensity, the Quality of Life (QOL), disability, and depression statuses were assessed prior to and one week after the treatment. Shapiro-Wilks goodness-of-fit test for normality, dependent t-Test, and Wilcoxon Signed- Rank Test were used for data analysis. Values of p < .05 were considered statistically significant. FINDINGS: Active tDCS treatment was effective in the reduction of pain (p = .0001), improving QOL (208.938 > 193.313, P = .025), and the disability (22.375 < 30.375, P = .025). The results showed no effect of active or sham treatment on the depression (p ≥ .05). CONCLUSION: The positive effects of active tDCS on CPP suggest the need to study the effect of this method on other types of chronic pain.

Kinematics of the Spine During Sit-to-Stand Movement Using Motion Analysis Systems: A Systematic Review of Literature.

CONTEXT: Clinical evaluation of the spine is commonplace in musculoskeletal therapies, such as physiotherapy, physical medicine/rehabilitation, osteopathic, and chiropractic clinics. Sit-to-stand (STS) is one of the most mechanically demanding daily activities and crucial to independence. Difficulty or inability to perform STS is common in individuals with a variety of motor disabilities, such as low back pain (LBP). OBJECTIVE: The purpose of this systematic review was to evaluate available evidence in literature to determine 2-dimensional and 3-dimensional kinematics of the spine during STS in patients with LBP and healthy young adult participants using motion analysis systems (electromagnetic and marker based). METHODS: Electronic databases (PubMed/MEDLINE [National Library of Medicine], Scopus, ScienceDirect, and Google Scholar) were searched between January 2002 and February 2017. Additionally, the reference lists of the articles that met the inclusion criteria were also searched. Prospective studies published in peer-reviewed journals, with full text available in English, investigating the kinematics of the spine during STS in healthy subjects (mean age between 18 and 50 y) or in patients with LBP using motion analysis systems, were included. Sixteen studies fulfilled the eligibility criteria. All information relating to methodology and kinematic modeling of the spine segments along with the outcome measures was extracted from the studies identified for synthesis. RESULTS: The results indicated that the kinematics of the spine are greatly changed in patients with LBP. In order to develop a better understanding of spine kinematics, studies recommended that the trunk should be analyzed as a multisegment. It has been shown that there is no difference between the kinematics of patients with LBP and healthy population when the spine is analyzed as a single segment. Furthermore, between-gender differences are present during STS movement. CONCLUSION: This review provided a valuable summary of the research to date examining the kinematics of the spine during STS.

The Effects of Forward Head Posture on Neck Extensor Muscle Thickness: An Ultrasonographic Study.

OBJECTIVE: This study aimed to compare neck extensor muscle thickness, thickness changes, and strength between participants with forward head posture (FHP) and controls with normal head posture (NHP). METHODS: Twenty college students with FHP (mean age 21.30 ± 2.36 years) and 20 students with NHP (mean age 21.85 ± 2.78 years) participated in this case-control study. The thickness of neck extensor muscles was measured at rest and at maximal voluntary isometric contraction (MVIC). In addition, the craniovertebral angle (CVA) was calculated. To compare thickness changes between the 2 groups and among 5 muscles, a 2-way repeated measures analysis of variance was applied. In addition, Pearson's correlation test was performed to investigate the relationship between neck extensor MVIC and CVA. RESULTS: The FHP group demonstrated lower MVIC compared with the NHP group (P = .03). Semispinalis capitis showed the smallest thickness changes during neck extensor MVIC in FHP compared with the controls (P < .001). However, no significant difference in terms of muscle thickness was observed between the 2 groups at the state of rest (P = .16-.99). A positive association was also found between the MVIC and CVA (P = .02). CONCLUSIONS: Semispinalis capitis had less thickness changes during MVIC of neck extensors in individuals with FHP compared with those with NHP. This indirectly implies lower activity of this muscle in FHP condition. This study finding may help researchers develop therapeutic exercise protocols to manage FHP.

The Effect of 2 Different Exercise Programs on Pain Intensity and Muscle Dimensions in Patients With Chronic Low Back Pain: A Randomized Controlled Trial.

OBJECTIVES: The purpose of this study was to compare the effect of 2 exercise programs combined with electrotherapy on pain intensity and lumbar stabilizer muscles dimensions in patients with nonspecific chronic low back pain. METHODS: A randomized controlled clinical trial was performed with 41 patients with chronic LBP. Participants were randomly allocated into 2 groups: an experimental group (n = 20) received stabilization exercises plus electrotherapy, and a control group (n = 21) received routine exercises plus electrotherapy. Pain intensity, using a visual analog scale, and muscle dimensions of both right and left transverse abdominis and lumbar multifidus muscles, using rehabilitative ultrasonography, were assessed before and immediately after 4 weeks of intervention. RESULTS: Significant improvement was identified after interventions on pain intensity and muscle size measurements in both groups (P < .01 in all instances). The only exception was the right-side lumbar multifidus cross-sectional area of the control group, which was not statistically significant (P = .081). No significant differences were found between the 2 exercise groups on pain intensity and muscle dimensions (P > .05 in all instances). CONCLUSIONS: The results of this study suggest that a combination of electrotherapy with either routine or stabilization exercise programs may improve pain intensity and muscle dimensions in patients with nonspecific chronic low back pain.

Immediate effect of common peroneal nerve electrical stimulation on quadriceps muscle arthrogenic inhibition in patients with knee osteoarthritis.

OBJECTIVE: To investigate the immediate effect of electrical stimulation of the common peroneal nerve on the maximum voluntary activation of the quadriceps muscle in patients with knee osteoarthritis. METHODOLOGY: Fifteen subjects with knee osteoarthritis (mean age: 50.5 ± 13 years) participated in this study. To measure the arthrogenic inhibition ratio of quadriceps, a burst of electrical stimulation was superimposed on the maximum voluntary contraction, and the percentage of change in the force production was computed. The same measurement was also performed with concurrent electrical stimulation of the common peroneal nerve. RESULTS: All the patients with knee osteoarthritis showed significant arthrogenic inhibition of the quadriceps muscle. The stimulation of the common peroneal nerve was able to reduce this inhibition and increase the capacity of the muscle to produce a significantly higher knee extension force (p = 0.028). CONCLUSIONS: Electrical stimulation of the common peroneal nerve concurrent with the maximum voluntary effort can remove the arthrogenic inhibition of the quadriceps muscle in patients with knee osteoarthritis. This finding could have clinical implications in the management of patients with knee disorders.

Lower limb muscular activity during walking at different speeds: Over-ground versus treadmill walking: A voluntary response evaluation.

OBJECTIVE: To evaluate the overall lower limb muscular activity pattern during treadmill walking compared to over-ground walking. METHODOLOGY: The study was conducted on 25 healthy young females. Surface electromyography was recorded from gastrocnemius, hamstrings, vasti and gluteus medius muscles during walking over-ground and treadmill at 3 different speeds (comfortable, slow and fast). The pattern of muscle activity was compared between two walking conditions at different speeds by the voluntary response index method. Voluntary response index is composed of two numeric values: magnitude which represents the strength of overall muscular activity, and similarity index which represents the resemblance of overall muscle activity. RESULTS: The main effect of walking conditions and speed as well as their interaction effect (P < 0.001) on magnitude of muscle activity were significant but not for similarity index. CONCLUSIONS: The pattern of muscular activity during walking on treadmill and over-ground was similar but walking on treadmill induced higher muscular activity in the lower limb musculature.

The effects of inter-trial interval on implicit learning of sequential visual isometric pinch task.

Sequential visual isometric pinch task (SVIPT) has been recently used as a visuomotor sequence task in clinical research. The influence of varying intervals between sequenced trials on the acquisition of implicit sequence learning is not yet determined for SVIPT. The aim of this study was to investigate the effects of inter-trial interval (ITI) on implicit motor sequence learning using SVIPT. A total of 32 healthy participants with mean age 31.3 ± 4.5 years participated in this study. Participants were randomly assigned to one of four ITI groups; (1, 2, 3 and 4 s). They were instructed to control their force on a force transducer to reach a number of targets which appeared on the computer screen by changing the pinch force exerted onto the transducer. In this study, outcome measures were movement time, error rate and skill, which were measured before and after training. Our results indicated that motor sequence learning similarly affected various ITIs. Indeed, all participants exhibited same improvement in implicit learning of SVIPT even though the ITIs varied from 1 to 4 s. Our findings suggest that implicit learning of SVIPT is independent of ITI within this range in healthy individuals.

Mechanosensitivity of the median nerve in patients with chronic carpal tunnel syndrome.

The aim was to investigate the relationship between the effects of median nerve strain during the elbow extension component of the upper limb neurodynamic test 1 (ULNT1) and the evoked musculoskeletal changes. 11 patients with chronic carpal tunnel syndrome (CTS) and 11 matched asymptomatic controls participated in the study. In all subjects, elbow extension was carried out in both ULNT1 and neutral positions of the shoulder and arm. From these two starting positions a KIN-COM(®) dynamometer carried out passive elbow extension while EMG activity of 10 arm and shoulder muscles, elbow-flexor resistive torque and elbow extension ROM were measured concurrently. The result showed that, in the ULNT1 position, increased EMG activity of the involved muscles, increased elbow extension resistive torque and pain responses occurred much earlier in the range of elbow extension in the CTS group compared to healthy controls. These findings demonstrated increased mechanosensitivity of the median nerve in CTS patients compared to healthy controls.

The impact of load and base of support on electromyographic onset in the shoulder muscle during push-up exercises.

OBJECTIVE: To investigate the effects of base of support (BOS) and external loads on electromyographic (EMG) onset in the shoulder muscles during push-up exercises. METHODS: Two levels of external load were applied at two levels of BOS stability during push-up exercises. EMG onset in six shoulder muscles was measured in 30 healthy participants. RESULTS: With load set at 4% of body weight (BW), EMG onset in the lower trapezius (LT) (P = 0.003) and biceps brachia (BB) (P = 0.001) was significantly decreased with no load. Conversely, in other muscles (the upper trapezius (UT), teres major (TM), seratus anterior (SA) and deltoid posterior (DP)), time to EMG onset did not change significantly. No significant changes in EMG onset were observed with load at 2% of BW. The average time to EMG onset was significantly decreased for different stages of BOS instability in the LT (P = 0.04) and UT (P = 0.001). CONCLUSION: Both load and BOS instability reduce time to EMG onset, but BOS instability produces greater reductions.

Validity and reliability of skin markers for measurement of intersegmental mobility at L2-3 and L3-4 during lateral bending in healthy individuals: a fluoroscopy study.

It is clinically important to assess kinematic parameters of lumbar spine movement to increase our understanding of lumbar mobility impairments in patients with low back pain. This is the first step for restoration of motor function. The use of non-invasive surface markers has currently attracted the interests of many researchers but scientific utilization of this technique for clinical research requires validity and reliability studies. The aim of the present study was to examine whether skin markers can be used to measure lumbar motions during lateral bending. Twelve healthy individuals were lying in prone position on the video fluoroscopy table and skin markers were attached over their spinous processes. Fluoroscopy images were taken in two positions of neutral and right lateral bending (RLB). The correlation of the L2-3 and L3-4 angles and lumbar curvature between markers and vertebrae measurements in the neutral and RLB positions was determined by Pearson Correlation Coefficient. The Intraclass correlation coefficient (ICC) was used to measure inter-examiner reliability of measurement in five participants. The results showed high reliability (ranging from 0.94 to 0.99) for angular measurements at L2-3 and L3-4 and lumbar curvature and also significant correlation between angular measurement derived from markers and vertebrae at L2-3 (r = 0.7, p = 0.015), L3-4 and lumbar curvature (r = 0.91 p = 0.001). The results showed that motions of skin markers follow the motions of the assigned underlying lumbar vertebrae. Therefore, skin markers can be confidently used for estimation of lumbar movements during lateral bending.

Muscular load to the therapist's shoulder during three alternative techniques for trigger point therapy.

AIM: To compare the muscular load (level of muscle activity) to the shoulder during alternative approaches to trigger point therapy (TPT). METHOD: Massage therapy students (n=7) applied a predetermined level of force to an artificial contact surface. Changes in five pairs of superficial shoulder muscles (indicated by surface electromyography) were recorded while the student performed the single-arm technique (SAT), the double-arm technique (DAT) and the treatment-tool technique (TTT) using TriggerMate, a new treatment tool. RESULTS: For the contact arm, muscle activity was significantly decreased using the TTT compared to the SAT (p<0.05) but was not significantly different between the TTT and DAT. For the non-contact arm, none of the test techniques led to significant differences in muscle activity. CONCLUSIONS: While there is evidence that the TTT decreases the muscular load to the shoulder of the contact arm, there is no indication of where this load is redistributed.