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J Mater Chem B ; 7(32): 4927-4932, 2019 08 28.
Artículo en Inglés | MEDLINE | ID: mdl-31359022

RESUMEN

The combination of selenium and pillararenes to prepare selenium-containing pillararene-based biomaterials is of great significance for the development of biomedicine. Herein, using a covalent self-assembly strategy, we successfully developed new diselenium-containing ultrathin polymer nanocapsules based on lateral cross-linked pillararenes. The new system exhibited a very potent anticancer effect; additionally, the incorporation of the cleavable redox diselenium bond into the polymer nanocapsules provided a smart nanocarrier for drug delivery. Moreover, the polymer nanocapsules were developed for anticancer drug targeting delivery by loading an anticancer drug and introducing the tumor-penetrating peptide RGD through the host-guest interaction strategy. The targeting DOX-loaded diselenium-containing polymer nanocapsules exhibited enhanced stability, self-anticancer effect, targeted delivery and controlled drug release, resulting in effective combined inhibition of tumor progression.


Asunto(s)
Antineoplásicos/química , Antineoplásicos/farmacología , Portadores de Fármacos/química , Nanocápsulas/química , Polímeros/química , Selenio/química , Doxorrubicina/química , Doxorrubicina/farmacología , Liberación de Fármacos , Humanos , Células MCF-7 , Modelos Moleculares , Conformación Molecular , Oxidación-Reducción , Compuestos de Amonio Cuaternario/química
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