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Medicinas Complementárias
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1.
Exp Neurol ; 342: 113736, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-33945790

RESUMEN

Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.


Asunto(s)
Corteza Cerebral/fisiología , Hemorragia Cerebral Intraventricular/terapia , Disfunción Cognitiva/terapia , Trasplante de Células Madre Mesenquimatosas/métodos , Plasticidad Neuronal/fisiología , Tálamo/fisiología , Animales , Animales Recién Nacidos , Células Cultivadas , Corteza Cerebral/diagnóstico por imagen , Hemorragia Cerebral Intraventricular/diagnóstico por imagen , Hemorragia Cerebral Intraventricular/fisiopatología , Disfunción Cognitiva/diagnóstico por imagen , Disfunción Cognitiva/fisiopatología , Potenciales Postsinápticos Excitadores/fisiología , Humanos , Potenciales Postsinápticos Inhibidores/fisiología , Imagen por Resonancia Magnética/métodos , Masculino , Ratas , Ratas Sprague-Dawley , Tálamo/diagnóstico por imagen
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