1.
Phytomedicine
; 8(6): 454-9, 2001 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11824520
RESUMEN
A series of naturally occurring 8.0.4'-neolignans (1a-d, 1g, 2g, 2h) and their analogues (le-f, lh, 1i, 2a-f, 2i) have been synthesized in racemic form starting from commercially available phenols, such as eugenol, isoeugenol and 4-allyl-2,6-dimethoxyphenol and from aromatic aldehydes, such as piperonal, veratraldehyde and 3,4,5-trimethoxybenzaldehyde. The inhibitory activity of these compounds on superoxide anion (O2.-) release by human polymorphonuclear leukocytes (PMNLs) was tested and the structure-activity relationship was also studied.
Asunto(s)
Antioxidantes/farmacología , Eugenol/análogos & derivados , Lignanos/farmacología , Aldehídos/química , Benzaldehídos/química , Benzodioxoles , Células Cultivadas , Eugenol/química , Humanos , Lignanos/síntesis química , Neutrófilos/citología , Neutrófilos/efectos de los fármacos , Neutrófilos/metabolismo , Fenoles/química , Relación Estructura-Actividad Cuantitativa , Superóxidos/metabolismo
2.
Yakugaku Zasshi
; 104(11): 1198-206, 1984 Nov.
Artículo
en Japonés
| MEDLINE
| ID: mdl-6530663