Colon stenosis caused by old portal vein thrombosis.

A 58-year-old female with a history of portal vein thrombosis was referred to our hospital with abdominal pain and distention. Colon fiber and enema of the colon showed stenosis at the transverse colon and the ascending colon, with edematous mucosa. Laparotomy revealed no abnormal findings other than chronic ischemia of the colon. To our knowledge, this is the first reported case of colon stenosis caused by portal vein thrombosis.

Preliminary screening of plants used in South Africa as traditional herbal remedies during pregnancy and labour.

Agapanthus africanus, Pentanisia prunelloides and Gunnera perpensa are indigenous plants which are used in traditional herbal remedies during pregnancy and childbirth. A crude decoction of each plant was tested on isolated rat uterus and ileum for pharmacological activity. Agapanthus africanus and Pentanisia prunelloides exhibited direct smooth muscle activity on the uterus and ileum preparations, while Gunnera perpensa showed direct smooth muscle activity on the uterus only. All the plant extracts potentiated the initial response of the uterus to oxytocin but Pentanisia prunelloides reduced the maximum response of the uterus to oxytocin. The Agapanthus africanus and Pentanisia prunelloides extracts potentiated the initial response of the ileum to acetylcholine but all the plant extracts inhibited the maximum response of the ileum to acetycholine.

Effects of exercise on immune functions of undernourished mice.

Regular moderate exercise may modulate the response to a stressor and thus improve immune functions in conditions commonly associated with immunodepression and elevated levels of stress hormones. For example, anorexia nervosa patients, many of whom engage in regular aerobic exercise, generally have normal immune function and viral disease resistance in spite of their severe undernutrition. To test the hypothesis that exercise can prevent undernutrition-induced immunodepression, mice were fed a nutritionally complete, semi-purified diet, either ad libitum or in restricted quantities to induce 25% loss of initial weight over 3 weeks. Half the animals from each dietary group were run on a treadmill for 30 min/day, 5 days/week. Exercise had no effect on several measures of nutritional status. Spleen weight and blastogenic response to lipopolysaccharide were significantly increased by exercise in undernourished mice. In vivo antibody response to sheep red blood cells, and in vitro splenic responses to concanavalin A and phytohemagglutin were not significantly affected by exercise. Serum corticosterone level was increased by food restriction and significantly decreased by exercise in the undernourished mice. Within a treatment group there were no significant correlations between serum corticosterone level and any immune system measure. Hypothalamic concentration of uric acid was increased in food restriction groups and concentration of norepinephrine was increased in exercise groups. The results suggest that regular exercise may help prevent undernutrition-induced immunodepression, possibly through modulation of the stress response.